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The features of a humoral response in patients with COVID-19

DOI: https://doi.org/10.29296/25877305-2021-12-01
Issue: 
12
Year: 
2021

L. Generalova(1); Professor O. Burgasova(1, 3), MD; V. Gushchin(2, 3), Candidate of Biological
Sciences; Professor L. Kolobukhina(3), MD; V. Bakalin(1); V. Tetova(1), Candidate of Medical Sciences; M.
Odnoralov(1), E. Generalov(2), Candidate of Physical and Mathematical Sciences (1)Peoples Friendship
University of Russia, Moscow (2)M.V. Lomonosov Moscow State University (3)N.F. Gamaleya National Research
Center for Epidemiology and Microbiology, Moscow

The article provides a brief overview of the accumulated data on humoral and T-cell responses to SARS-CoV-2 in patients with COVID-19. It characterizes an antibody response, the neutralizing capacity of immunoglobulin G to the receptor-binding domain (RBD), the timing of antibody elimination, and avidity. RBD has been shown to be the main target for the production of neutralizing antibodies. Analysis and further study of the determinants of SARS-CoV-2 humoral response in patients with COVID-19 will be able to develop more advanced diagnostic techniques.

Keywords: 
infectious diseases
antiviral immunity
antibodies to COVID-19
neutralizing antibodies
timing of immune response
antibodies to the S protein
RBD
N-protein



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