Asthenic syndrome in Tuvinian schoolchildren: prevalence, age and gender differences, principles of treatment
DOI: https://doi.org/10.29296/25877305-2021-09-10
Issue:
9
Year:
2021
The paper reviews information on the etiology, risk factors, classification, clinical
manifestations, diagnosis and treatment of asthenic syndrome (AS) in pediatric patients, as well as the
results of the authors’ own studies of the prevalence of AS among Tuvinian schoolchildren. Objective: to
study the prevalence of AS in Tuvinian schoolchildren, to comparatively analyze age and gender differences
in this contingent with AS. Subjects and methods. In December 2020 to May 2021, cross-sectional screenings
were performed in the random samples of 11–18-year-old adolescents of both sexes (pupils from 7 schools in
Kyzyl and those from 1 school in the Kyzyl District). The survey involved 1148 teenagers (mean age, 13.7±1.6
years). The presence of AS was assessed using a screening questionnaire. The indicators were generally
compared in the entire sample of the surveyed schoolchildren, as well as in the gender (boys and girls) and
age (11–14 years and 15–18 years) groups. The data were processed using the Statistica 12 program for
Windows. Results. The incidence of AS was found to be 12.2% of the entire sample population of the surveyed
Tuvinian schoolchildren; AS was more common in the girls (17.8%) than in the boys (5.8%). There tended to be
a higher prevalence of AS in the younger age group (13.3%) than in the older one (9.3%). The incidence of AS
in the girls of both age groups was higher than that in the boys of the same age range. The findings suggest
that there is a need for further investigation of various aspects of asthenic conditions in pediatric
patients.
Keywords:
pediatrics
schoolchildren
asthenia
asthenic syndrome
risk factors
principles of treatment
References:
- Berezhnoj V.V., Kurilo L.V., Marushko T.V. i dr. Effektivnost' metabolicheskoj korrektsii atsetonemicheskogo sindroma u detej. Sovremennaja pediatrija. 2009; 5: 89 [Berezhnoy V.V., Kurilo L.V., Marushko T.V. et al. The effectiveness of metabolic correction of acetonemic syndrome in children. Modern pediatrics. 2009; 5: 89 (in Russ.)].
- Bochanova E.N., Gatskih I.V., Potupchik T.V. i dr. Sravnitel'nyj analiz polivitaminov dlja detej. Voprosy biologicheskoj, meditsinskoj i farmatsevticheskoj himii. 2020; 23 (11): 10–5 [Bochanova E.N., Gatskikh I.V., Potupchik T.V. et al. Comparative analysis of multivitamins for children. Problems of biological, medical and pharmaceutical chemistry. 2020; 23 (11): 10–5 (in Russ.)]. DOI: 10.29296/25877313-2020-11-02
- Brin I.L. El'kar v pediatrii. Nauchnyj obzor. M., 2004 [Brin I.L. Elkar in pediatrics. Scientific review. M., 2004 (in Russ.)].
- Burchinskij S.G. Kontseptsija mnozhestvennoj selektivnosti v nejrofarmakologii i klinicheskij vybor nootropnogo preparata. Novosti meditsiny i farmatsii. 2015; 1 (525): 3–5 [Burchinsky S.G. The concept of multiple selectivity in neuropharmacology and the clinical choice of a nootropic drug. News of medicine and pharmacy. 2015; 1 (525): 3–5 (in Russ.)].
- Vasil'ev A.S. Farmakologicheskie effekty ekstraktov ekdisteroidsoderzhaschih rastenij v uslovijah povyshennoj vjazkosti krovi. Avtoref. dis. ... d-ra biol. nauk. Tomsk, 2012 [Vasiliev A.S. Pharmacological effects of extracts of ecdysteroid-containing plants in conditions of increased blood viscosity. Abstract of the dis. ... Doctor of Biological Sciences. Tomsk, 2012 (in Russ.)].
- Vahnina N.V., Kalimeeva E.Ju. Primenenie vitaminno-mineral'nyh kompleksov v sostave nootropnoj terapii pri astenicheskih sostojanijah i nevrologicheskih rasstrojstvah. Meditsinskij sovet. 2015; 11: 12–6 [Vakhnina N.V., Kalimeeva E.Yu. Use of vitamin & mineral supplements in nootropic therapy for asthenic conditions and neurological disorders. Meditsinskiy sovet = Medical Council. 2015; 11: 12–6 (in Russ.)]. DOI: 10.21518/2079-701X-2015-11-12-16
- Volosovets A.P. Optimizatsija farmakoterapii astenii v praktike sovremennoj pediatrii. Novosti meditsiny i farmatsii. 2007; 4: 208 [Volosovets A. P. Optimization of asthenia pharmacotherapy in the practice of modern pediatrics. News of medicine and pharmacy. 2007; 4: 208 (in Russ.)].
- Volosovets A.P., Krivopustov S.P., Kozhina A.N. i dr. Atsetonemicheskij sindrom u detej: sovremennyj vzgljad na problemu. Zdorov'e rebenka. 2009; 6: 76–81 [Volosovets A.P., Krivopustov S.P., Kozhina A.N., Shcherbinskaya E.N. Acetonemic syndrome in children: a modern view of the problem. The child’s health. 2009; 6: 76–81. (in Russ.)].
- Gosudarstvennyj reestr lekarstvennyh sredstv [Elektronnyj resurs]: [State Register of medicinal products [Electronic resource] (in Russ.)]. Rezhim dostupa / Access mode: https://grls.rosminzdrav.ru/Default.aspx
- Zajtseva O.I., Tereschenko V.P., Prahin E.I. i dr. Osobennosti formirovanija vegetativnogo gomeostaza u detej shkol'nogo vozrasta v razlichnyh regionah Sibiri. Uspehi sovremennogo estestvoznanija. 2005; 4: 13–6 [Zaitseva O.I., Tereshchenko V.P., Prakhin E.I. et al. Features of the formation of vegetative homeostasis in school-age children in various regions of Siberia. Uspekhi sovremennogo estestvoznaniya. 2005; 4: 13–6 (in Russ.)].
- Ivanov D.D., Kushnirenko S.V. Primenenie stimola v detskoj nefrologii: korrektsija metabolicheskih narushenij pri tubulopatijah, hronicheskoj pochechnoj nedostatochnosti, glomerulonefrite, pielonefrite i tubulo-interstitsial'nom nefrite u detej. Sovremennaja pediatrija. 2011; 5 (39): 195 [Ivanov D.D., Kushnirenko S.V. The use of stimol in pediatric nephrology: correction of metabolic disorders in tubulopathies, chronic renal failure, glomerulonephritis, pyelonephritis and tubulo-interstitial nephritis in children. Modern pediatrics. 2011; 5 (39): 195 (in Russ.)].
- Kalinina M.A., Kozlovskaja G.V., Kremneva L.F. Levokarnitin v detskoj praktike. RMZh. Meditsinskoe obozrenie. 2018; 10: 40–4 [Kalinina M.A., Kozlovskaya G.V., Kremneva L.F. Levocarnitine in pediatric practice. RMJ. Medical Review. 2018; 10: 40–4 (in Russ.)].
- Kiseleva A.L. Stimol pri astenicheskih sostojanijah u detej. Praktika pediatra. 2012; 4: 637 [Kiseleva A.L. Stimol in asthenic conditions in children. The practice of a pediatrician. 2012; 4: 637 (in Russ.)].
- Kozlov V.A., Savchenko A.A., Kudrjavtsev I.V. i dr. Klinicheskaja immunologija. Krasnojarsk: Polikor, 2020; 386 s. [Kozlov V.A., Savchenko A.A., Kudryavtsev I.V. et al. Klinicheskaya immunologiya. Krasnoyarsk: Polikor, 2020; 386 s. (in Russ.)]. DOI: 10.17513/np.438
- Kon' I.Ja. Ratsional'noe pitanie v sohranenii zdorov'ja. Fiziologija rosta i razvitija detej i podrostkov. Pod red. A.A. Baranova, L.A. Schepljaginoj. M., 2000 [Kon I.Ya. Rational nutrition in the preservation of health. Physiology of growth and development of children and adolescents. Ed. by A.A. Baranov, L.A. Shcheplyagina. M., 2000 (in Russ.)].
- Kurkin V.A., Avdeeva E.V., Kurkina A.V. i dr. Aktual'nye aspekty sozdanija importozameschajuschih adaptogennyh lekarstvennyh rastitel'nyh preparatov. Mezhdunarodnyj zhurnal eksperimental'nogo obrazovanija. 2015; 11–3: 455–7 [Kurkin VA., Avdeeva E. V., Kurkina A.V. et al. Actual aspects of creating import-substituting adaptogenic medicinal herbal preparations. International Journal of Experimental Education. 2015; 11–3: 455–7 (in Russ.)].
- L'vova O.A., Shal'kevich L.V., Rodtsevich O.G. i dr. Astenicheskie sostojanija v detskom vozraste: Ucheb.-metod. posob. Minsk, 2014 [Lvova O.A., Shalkevich L.V., Rodtsevich O.G. et al. Asthenic conditions in childhood: Textbook-method. stipend. Minsk, 2014 (in Belarus)].
- Maslova O.I., Studenikin V.M., Chibisov I.V. i dr. Effektivnost' primenenija preparata Pantogam sirop 10% (gopantenovaja kislota) v korrektsii kognitivnyh rasstrojstv u detej. Voprosy sovremennoj pediatrii. 2004; 3 (4): 2–6 [Maslova O.I., Studenikin V.M., Chibisov I.V., Balkanskaya S.V. Kuzenkova L.M. Efficacy of the use of Pantoham syrup 10% (hopantenic acid) for correction of cognitive disorders in children. Voprosy sovremennoi pediatrii = Current Pediatrics. 2004; 3 (4): 2–6 (in Russ.)].
- Nemkova S.A. Sovremennye printsipy lechenija postinfektsionnyh astenicheskih sostojanij u detej. RMZh. 2016; 6: 368–72 [Nemkova S.A. Modern principles of treatment of post-infectious asthenic conditions in children. RMJ. 2016; 6: 368–72 (in Russ.)].
- Popov Ju.V. Primenenie Nooklerina u podrostkov v kachestve antiastenicheskogo sredstva. Psihiatrija i psihofarmakoterapija. 2004; 6 (4): 194–7 [Popov Yu.V. The use of Nooklerin in adolescents as an antiasthenic agent. Psychiatry and psychopharmacotherapy. 2004; 6 (4): 194–7 (in Russ.)].
- Potupchik T.V., Veselova O.F., Evert L.S. i dr. Korrektsija kognitivnyh narushenij u detej s ispol'zovaniem nootropnyh preparatov. Obozrenie psihiatrii i meditsinskoj psihologii imeni V.M. Behtereva. 2015; 3: 109–13 [Potupchik TV., Veselova O.F., Evert L.S. et al. Correction of cognitive impairment in children with the use of nootropic drugs. Review of psychiatry and medical psychology named after V.M. Bekhterev. 2015; 3: 109–13 (in Russ.)].
- Potupchik T.V., Veselova O.F., Evert L.S. i dr. Spektr farmakologicheskih effektov glitsina. Vrach. 2015; 12: 14–7 [Potupchik T.V., Veselova O.F., Evert L.S. et al. A spectrum of pharmacological effects of glycine. Vrach. 2015; 12: 14–7 (in Russ.)].
- Potupchik T.V., Evert L.S., Veselova O.F. i dr. Profilaktika i korrektsija narushenij adaptatsionno-prisposobitel'nyh protsessov u detej. Meditsinskaja sestra. 2016; 3: 54–5 [Potupchik T.V., Evert L.S., Veselova O.F. et al. Method of prevention and correction of disorders of adaptive processes in children. Meditsinskaya sestra. 2016; 3: 54–5 (in Russ.)].
- Sejfulla R.D., Potupchik T.V., Polubojarinov P.A. i dr. Vozmozhnosti primenenija kombinirovannogo adaptogena Leveton P. Vrach. 2018; 29 (10): 37–44 [Seifulla R., Potupchik T., Poluboyarinov P. et al. Possibilities of using the combined adaptogen Leveton P. Vrach. 2018; 29 (10): 37–44 (in Russ.)]. DOI: 10.29296/25877305-2018-10-10
- Trepilets V.M., Bykova O.V., Hachatrjan L.G. Primenenie preparata Kogitum u detej s detskim tserebral'nym paralichom i narushenijami rechi. Nervnye bolezni. 2021; 1: 39–44 [Trepilets V.M., Bykova O.V., Khachatryan L.G. Use of the Drug Cogitum in Children with Cerebral Palsy and Speech Disorders. Nervous diseases. 2021; 1: 39–44 (in Russ.)]. DOI: 10.24412/2226-0757-2021-12306
- Chutko L.S. Primenenie deanola atseglumata pri lechenii nevrastenii u podrostkov so shkol'noj dezadaptatsiej. Voprosy sovremennoj pediatrii. 2013; 12 (5): 99–103 [Chutko L.S. The use of Nooklerin in the treatment of neurasthenia in adolescents with school maladaptation. Voprosy sovremennoi pediatrii = Current Pediatrics. 2013; 12 (5): 99–103 (in Russ.)]. DOI: 10.15690/vsp.v12i5.806
- Shabanov P.D., Ganapol'skij V.P., Zhumasheva A.B. i dr. Trekrezan kak metabolicheskij aktivator, obladajuschij svojstvami meteoadaptogena, psihoenergizatora i immunomoduljatora. Vestnik Rossijskoj voenno-meditsinskoj akademii. 2006; 15 (1): 53–7 [Shabanov P.D., Ganapol’skii V.P., Zhumasheva A.B. et al. Trekrezan kak metabolicheskii aktivator, obladayushchii svoistvami meteoadaptogena, psikhoenergizatora i immunomodulyatora. Vestnik Rossiiskoi voenno-meditsinskoi akademii. 2006; 15 (1): 53–7 (in Russ.)].
- Shavlovskaja O.A. Vitaminy gruppy «V» v nevrologicheskoj praktike. RMZh. 2013; 21 (30): 1582–5 [Shavlovskaya O.A. Vitamins of group «B» in neurological practice. RMJ. 2013; 21 (30): 1582–5 (in Russ.)].
- Shavlovskaja O.A. Terapija astenii i svjazannyh s nej sostojanij preparatami vitaminno-mineral'nogo kompleksa. Meditsinskij sovet. 2015; 17: 55–61 [Shavlovskaya O.A. Treatment of asthenia and associated conditions with vitamin and mineral supplements. Meditsinskiy sovet = Medical Council. 2015; 17: 55–61 (in Russ.)]. DOI: 10.21518/2079-701X-2015-17-55-61
- Shal'kevich L.V., Malash A.V. Astenija v pediatricheskoj praktike: vzgljad nevrologa. Meditsinskie novosti. 2016; 9: 5–9 [Shalkevich L.V., Malash A.V. Asthenia in pediatric practice from the neurologist’s standpoint. Meditsinskie novosti. 2016; 9: 5–9 (in Russ.)].
- Caram-Salas N.L., Reyes-Garcia G., Medina-Santillán R., et al. Thiamine and cyanocobalamin relieve neuropathic pain in rats: synergy with dexamethasone. Pharmacology. 2006; 77 (2): 53–62. DOI: 10.1159/000092643
- Chutko L.S., Surushkina S.I., Nikishena I.S., et al. Asthenic disorders in children and their differentiated treatment. Zh Nevrol Psikhiatr Im S.S Korsakova. 2014; 114 (12): 99–103. DOI: 10.17116/jnevro201411412199-103
- Cox M., Lehninger A.L., Nelson D.R. Lehninger principles of biochemistry. New York: Worth Publishers, 2000. DOI: 10.1007/978-3-662-08289-8
- Goryunova A.V., Shevchenko Yu.S., Goryunov A.V. Cogitum in children’s neurology and psychiatry (experience in the practical use). Zh Nevrol Psikhiatr Im S.S. Korsakova. 2019; 119 (7): 58–66. DOI: 10.17116/hirurgia20190715
- Milovanova O.A., Astanina S.Yu. Treatment of asthenoneurotic disorders in children. Zh Nevrol Psikhiatr Im S.S. Korsakova. 2016; 116 (12): 112–3. DOI: 10.17116/jnevro2016116121112-113
- Picot D., Garin L., Trivin F. et al. Plasma citrulline is a marker of absorptive small bowel length in patients with transient enterostomy and acute intestinal failure. Clin Nutr. 2010; 29 (2): 235–42. DOI: 10.1016/s0016-5085(03)00170-7