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The impact of glycine and lisinopril therapy on quality of life in young males with androgen deficiency and hypertension

DOI: https://doi.org/10.29296/25877305-2021-09-07
Issue: 
9
Year: 
2021

M. Khabibulina, Candidate of Medical Sciences; M. Shamilov Ural State Medical University,
Yekaterinburg

The effects of glycine and lisinopril on quality of life (QOL) in young males with hypertension and androgen deficiency were studied using the 36-Item Short Form Health Survey (SF-36). During combination therapy with glycine and lisinopril, the QOL in the males with hypertension and androgen deficiency was found to improve in all indicators of the SF-36 test. The drugs are well tolerated by the patients; glycine is combined with cardiotropic therapy.

Keywords: 
therapy
cardiology
quality of life
males
hypertension
androgen deficiency
glycine
lisinopril



References: 
  1. El-Sakka A.I. Erectile dysfunction, depression, and ischemic heart disease: does the existence of one component of this triad necessitate inquiring the other two? J Sex Med. 2011; 8 (4): 937–40. DOI: 10.1111/j.1743-6109.2011.02231.x
  2. Habibulina M.M. Tserebral'naja gemodinamika pri arterial'noj gipertenzii i androgenodefitsite. Vrach. 2018; 29 (4): 26–32 [Khabibulina M. Cerebral hemodynamics in hypertension and androgen deficiency. Vrach. 2018; 29 (4): 26–32 (in Russ.)]. DOI: 10.29296/25877305-2018-04-04
  3. Fedorova N.N., Habibulina M.M. Sutochnyj profil' arterial'nogo davlenija u muzhchin s gipertonicheskoj bolezn'ju II stadii v zavisimosti ot urovnja testosterona. Mat-ly IV Vseross. konfe. «Protivorechija sovremennoj kardiologii: spornye i nereshennye voprosy». 2015; s. 40–2 [Fedorova N.N., Khabibulina M.M. Sutochnyi profil’ arterial’nogo davleniya u muzhchin s gipertonicheskoi bolezn’yu II stadii v zavisimosti ot urovnya testosterona. Mat-ly IV Vseross. konfe. «Protivorechiya sovremennoi kardiologii: spornye i nereshennye voprosy». 2015; r. 40–2 (in Russ.)].
  4. Fedorova N.N., Habibulina M.M. Remodelirovanie levyh kamer serdtsa u muzhchin s arterial'noj gipertenziej pri normal'nom i izmenennom gormonal'nom fone. Vrach. 2015; 12: 25–6 [Fedorova N., Khabibulina M. Left cardiac remodeling in male hypertensive patients having a normal or altered hormonal profile. Vrach. 2015; 12: 25–6 (in Russ.)].
  5. Fedorova N.N., Habibulina M.M. Strukturnye izmenenija miokarda levogo zheludochka u muzhchin s arterial'noj gipertoniej i androgenodefitsitom. Mezhdunarodnyj zhurnal eksperimental'nogo obrazovanija. 2015; 11: 690–2 [Fedorova N.N., Khabibulina M.M. Strukturnye izmeneniya miokarda levogo zheludochka u muzhchin s arterial’noi gipertoniei i androgenodefitsitom. International Journal of Experimental Education. 2015; 11: 690–2 (in Russ.)].
  6. Bardage C., Isacson D. hypertension and health – related quality of life – en epidemiological study in Sweden. J Clin Epidimiol. 2001; 54 (2): 172–81. DOI: 10.1016/s0895-4356(00)00293-6
  7. Klocer M. et al. Quality of life in patients with essential arterial hypertension. Part II – the effect of clinical factors. Przeql Lek. 2003; 60 (2): 101–6.
  8. Laumann E.O. et al. Sexual dysfunction in the United States: Prevalence and predictors. JAMA. 1999; 281 (6): 537–44. DOI: 10.1001/jama.281.6.537
  9. Fedorova N.N., Habibulina M.M. Osobennosti chuvstvitel'nosti organizma eksperimental'nyh zhivotnyh k vozdejstviju nekotoryh psihitropnyh preparatov v hronofarmakologicheskom aspekte. Vestnik Ural'skogo gosudarstvennogo meditsinskogo universiteta. 2015; 2–3: 281–3 [Fedorova N.N., Khabibulina M.M. Osobennosti chuvstvitel’nosti organizma eksperimental’nykh zhivotnykh k vozdeistviyu nekotorykh psikhitropnykh preparatov v khronofarmakologicheskom aspekte. Vestnik Ural’skogo gosudarstvennogo meditsinskogo universiteta. 2015; 2–3: 281–3 (in Russ.)].
  10. Petrova E.V., Vakina T.N., Burmistrova L.A. Seksual'nye disfunktsii pri trevozhno-depressivnyh rasstrojstvah. Lechaschij vrach. 2014; 5: 108–11 [Petrova E.V., Vakina T.N., Burmistrova L.A. Seksual’nye disfunktsii pri trevozhno-depressivnykh rasstroistvakh. Lechashchii vrach. 2014; 5: 108–11 (in Russ.)].
  11. Habibulina M.M. Sposob diagnostiki razvitija erektil'noj disfunktsii u molodyh muzhchin s arterial'noj gipertenziej v zavisimosti ot urovnja testosterona, pokazatelej lipidnogo spektra, EhoKG – pokazatelej. Patent na izobretenie RU2601405 C1, 10.11.2016. Zajavka №2015128439/15 ot 13.07.2015 [Khabibulina M.M. Sposob diagnostiki razvitiya erektil’noi disfunktsii u molodykh muzhchin s arterial’noi gipertenziei v zavisimosti ot urovnya testosterona, pokazatelei lipidnogo spektra, EkhoKG – pokazatelei. Patent na izobretenie RU2601405 C1, 10.11.2016. Zayavka №2015128439/15 ot 13.07.2015 (in Russ.)].
  12. Petrova E., Shutov A. Therapeutic correction testosterone deficiency in hypertensive men with erectile dysfunction and depression. J Sex Med. 2016; 13 (5, Suppl. 2): 146. DOI: 10.1016/j.jsxm.2016.03.172
  13. Fedorova N.N., Habibulina M.M. Otsenka pokazatelej gormonal'nogo balansa u muzhchin s arterial'noj gipertenziej pri razlichnyh tipah remodelirovanija levogo zheludochka. Kazanskij meditsinskij zhurnal. 2016; 97 (3): 323–7 [Fedorova N.N., Habibulina M.M. Evaluation of hormonal balance indicators in men with arterial hypertension in various types of left ventricular remodeling. Kazan medical journal. 2016; 97 (3): 323–7 (in Russ.)]. DOI: 10.17750/KMJ2016-323
  14. Vlachopoulos C., Ioakeimidis N., Terentes-Printzios D. et al. Plasma total testosterone and incident cardiovascular events in hypertensive patients. Am J Hypertens. 2013; 26: 373–81. DOI: 10.1093/ajh/hps056
  15. Rosmond R., Wallerius S., Wanger P. et al. A 5-year follow-up study of disease incidence in men with an abnormal hormone pattern. J Intern Med. 2003; 254 (4): 386–90. DOI: 10.1046/j.1365-2796.2003.01205.x
  16. Shores M.M., Matsumoto A.M., Sloan K.L. et al. Low serum testosterone and mortality in male veterans. Arch Intern Med. 2006; 166: 1660–5. DOI: 10.1001/archinte.166.15.1660
  17. Novo S., Iacona R., Bonomo V. et al. Erectile dysfunction is associated with low total serum testosterone levels and impaired flow-mediated vasodilation in intermediate risk men according to the Framingham risk score. Atherosclerosis. 2015; 238 (2): 415–9. DOI: 10.1016/j.atherosclerosis.2014.12.007
  18. Spitzer M., Basaria S., Travison T.G. et al. The effect of testosterone on mood and well-being in men with erectile dysfunction in a randomized, placebo-controlled trial. Andrology. 2013; 1 (3): 475–82. DOI: 10.1111/j.2047-2927.2013.00075.x
  19. Lunenfeld B., Mskhalaya G., Zitzmann M. et al. Recommendations on the diagnosis, treatment and monitoring of hypogonadism in men. Aging Male. 2015; 18 (1): 5–15. DOI: 10.3109/13685538.2015.1004049
  20. Nuralieva N.F., Napalkov D.A. Depressija i serdechno-sosudistye zabolevanija. Vestnik RAMN. 2014; 9–10: 21–6 [Nuralieva N.F., Napalkov D.A. Depression and cardiovascular diseases. Vestnik Rossiiskoi Akademii Meditsinskikh Nauk = Annals of the Russian Academy of Medical Sciences. 2014; 9–10: 21–6 (in Russ.)]. DOI: 10.15690/vramn.v69i9-10.1127
  21. Fiedorowicz J.G. Depression and cardiovascular disease: an update on how course of illness may influence risk. Curr Psychiatry Rep. 2014; 16 (10): 492. DOI: 10.1007/s11920-014-0492-6
  22. Finnell J.E., Wood S.K. Neuroinflammation at the interface of depression and cardiovascular disease: Evidence from rodent models of social stress. Neurobiol Stress. 2016; 4: 1–14. DOI: 10.1016/j.ynstr.2016.04.001
  23. Mamedov M.N. Problemy muzhskogo zdorov'ja v kardiologicheskoj praktike. 2-e izd. M.: Kardioprogress, 2014; 173 s. [Mamedov M.N. Problemy muzhskogo zdorov’ya v kardiologicheskoi praktike. 2-e izd. M.: Kardioprogress, 2014; 173 r. (in Russ.)].
  24. Chrysant S.G. Antihypertensive therapy causes erectile dysfunction. Curr Opin Cardiol. 2015; 30 (4): 383–90. DOI: 10.1097/HCO.0000000000000189
  25. Al Khaja K.A., Sequeira R.P., Alkhaja A.K. et al. Antihypertensive Drugs and Male Sexual Dysfunction: A Review of Adult Hypertension Guideline Recommendations. J Cardiovasc Pharmacol Ther. 2016; 21 (3): 233–44. DOI: 10.1177/1074248415598321
  26. DeLay K.J., Haney N., Hellstrom W. Modifying Risk Factors in the Management of Erectile Dysfunction: A Review. World J Mens Health. 2016; 34 (2): 89–100. DOI: 10.5534/wjmh.2016.34.2.89
  27. Habibulina M.M. Terapija pri remodelirovanii serdtsa u molodyh muzhchin s AG, androgenodefitsitom i dislipidemiej. Vrach. 2019; 30 (3): 44–8 [Khabibulina M. Therapy for cardiac remodeling in young men with hypertension, androgen deficiency, and dyslipidemia. Vrach. 2019; 30 (3): 44–9 (in Russ.)]. DOI: 10.29296/25877305-2019-03-09
  28. Habibulina M.M., Fedorova N.N. Zamestitel'naja gormonal'naja i kardiotropnaja terapija u molodyh muzhchin s AG, izbytochnoj massoj tela i androgenodefitsitom. Vrach. 2018; 29 (7): 78–83 [Khabibulina M., Fedorova N. Hormone replacement and cardiotropic therapy in young men with hypertension, overweight, and androgen deficiency. Vrach. 2018; 29 (7): 78–83 (in Russ.)]. DOI: 10.29296/25877305-2018-07-18
  29. Habibulina M.M., Fedorova N.N. Sposob optimizatsii lechenija muzhchin kardiotropnoj terapiej i zamestitel'noj gormonal'noj terapiej pri androgenodefitsite s arterial'noj gipertenziej. Patent na izobretenie RU2632449 C1, 04.10.2017. Zajavka №2016116414 ot 26.04.2016 [Khabibulina M.M., Fedorova N.N. Sposob optimizatsii lecheniya muzhchin kardiotropnoi terapiei i zamestitel’noi gormonal’noi terapiei pri androgenodefitsite s arterial’noi gipertenziei. Patent na izobretenie RU2632449 C1, 04.10.2017. Zayavka №2016116414 ot 26.04.2016 (in Russ.)].
  30. Habibulina M.M., Fedorova N.N. Kardiotropnaja i zamestitel'naja gormonal'naja terapija pri sochetanii AG s androgenodefitsitom. Vrach. 2016; 10: 65–9 [Khablbullna M., Fedorova N. Cardiotropic and hormone replacement therapy for arterial hypertension concurrent with androgen deficiency. Vrach. 2016; 10: 65–9 (in Russ.)].
  31. Casper R.F., Yen S.S. Neuroendocrinology of menopausal flushes: an hypothesis of flush mechanism. Clin Endocrinol (Oxford). 1985; 22 (3): 293–312. DOI: 10.1111/j.1365-2265.1985.tb03243.x