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Using an ursodeoxycholic acid with mebeverine in patients with cholelithiasis after cholecystectomy

DOI: https://doi.org/10.29296/25877305-2021-09-05
Issue: 
9
Year: 
2021

Professor Yu. Uspenskiy(1, 2), MD; Professor Yu. Fominykh(1, 2), MD; K. Nadzhafova(1); A.
Kosheev(3), Candidate of Medical Sciences; A. Kosareva(1); D. Nikitina(1) (1)St.Petersburg State Pediatric
Medical University (2)Pavlov First St.Petersburg State Medical University (3)Mechnikov North-Western State
Medical University

Insufficient attention is often paid to the management of patients with cholelithiasis who have undergone cholecystectomy. The quality of life of such patients may remain low after the intervention due to a number of organic and functional disorders. The aim of our work was to evaluate the effectiveness and safety of taking a universal hepatoprotector based on ursodeoxycholic acid (UDCA) Exhol 500 mg and a selective antispasmodic based on mebeverin Sparex 200 mg in patients with cholelithiasis who underwent cholecystectomy. Materials and methods. The study involved 40 patients who passed elective cholecystectomy. The patients were divided into 2 groups of 20 people, the first group received treatment with a combination of drugs after surgical treatment, the second group received only non-drug recommendations. All patients before the operation and 3 months after it underwent a biochemical blood test, ultrasound of the abdominal cavity, MRCPG, gastroenterological complaints, quality of life and psychological status were evaluated. Conclusion. The complex scheme, including the appointment of a hepatoprotector based on UDCA (Exhol) and a selective antispasmodic (Sparex), demonstrates high efficacy and safety, and can be recommended for the management of patients with cholelithiasis who have undergone cholecystecomy.

Keywords: 
gastroenterology
cholelithiasis
cholecystectomy
ursodeoxycholic acid
mebeverine



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