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Pharmacogenetic technologies as part of a personalized approach for back pain

DOI: https://doi.org/10.29296/25877305-2021-09-04
Issue: 
9
Year: 
2021

S. Mitkovsky(1); N. Ponomareva(1), Candidate of Medical Sciences; V. Mitkovsky(1, 2), Candidate
of Medical Sciences; Professor E. Kiparisova(2), MD; Professor E. Ekusheva(2, 3), MD (1)Central Clinical
Hospital for Rehabilitation Treatment, Federal Biomedical Agency of Russia, Goluboe Village, Moscow Region
(2)Academy of Postgraduate Education, Federal Research and Clinical Center, Federal Biomedical Agency of
Russia, Moscow (3)Belgorod State National Research University

The paper presents an update on the feasibility of a personalized approach and sets forth the criteria for selecting patients with chronic pain for pharmacogenetic testing (PGT). Objective: to improve quality of life in patients with chronic pain through PGT and personalized therapy selection. Genotyping was performed in 22 patients with adverse reactions (ARs) as gastropathies associated with the intake of nonsteroidal anti-inflammatory drugs and hepatotoxicity. The results of CYP2C9*3, CYP2C9*3, and UGT1A1 genotypes were analyzed. According to the results of PGT, the therapy was corrected, causing the ARs to decrease.

Keywords: 
personalized medicine
pharmacogenetic study
biopsychosocial model of illness
multidisciplinary approach
chronic pain



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