Hypertension and erectile dysfunction: management tactics

DOI: https://doi.org/10.29296/25877305-2021-08-03
Download full text PDF
Issue: 
8
Year: 
2021

Associate Professor Z. Mikhailova(1), MD; Associate Professor A. Stroganov(2), MD (1)City
Clinical Hospital Thirty-Eight, Nizhny Novgorod (2)Volga Research Medical Center, Ministry of Health of
Russia, Nizhny Novgorod

Erectile dysfunction (ED) serves as an early marker or precursor for cardiovascular diseases. The most important pathogenetic component of hypertension and ED is pathological endothelial changes, insufficient nitric oxide production, chronic inflammation, and androgen deficiency. ED can also develop as a complication of antihypertensive therapy. When treating hypertension in males, it is recommended to evaluate sexual functioning regardless of age and to prescribe antihypertensive therapy individually. The issues of continuing sexual activity and treatment of ED should be discussed with the patient after assessing the risk of a cardiovascular event and stabilizing the condition.
Keywords: 
cardiology
hypertension
antihypertensive therapy
erectile dysfunction
phosphodiesterase type 5 inhibitors
cardiovascular events
quality of life

It appears your Web browser is not configured to display PDF files. Download adobe Acrobat или click here to download the PDF file.

References: 
  1. Arterial'naja gipertenzija u vzroslyh. Klinicheskie rekomendatsii. 2020. 136 s. [Arterial’naya gipertenziya u vzroslyh. Klinicheskie rekomendacii. 2020. 136 s. (in Russ.)].
  2. 2018 ESC/ESH Guidelines for the management of arterial hypertension. Eur Heart J. 2018; 39: 3021–104. DOI: 10.1093/eurheartj/ehy339
  3. Erektil'naja disfunktsija. Klinicheskie rekomendatsii. 2019; 30 s. [Erektil’naya disfunkciya. Klinicheskie rekomendacii. 2019; 30 s. (in Russ.)].
  4. Gratzke C., Angulo J., Chitaley K. et al. Anatomy, physiology, and pathophysiology of erectile dysfunction. J Sex Med. 2010; 7 (1 Pt 2): 445–75. Doi: 10.1111/j.1743-6109.2009.01624.x Erratum in: J Sex Med. 2010; 7 (3): 1316.
  5. Nehra A., Jackson G., Miner M. et al. The Princeton III Consensus recommendations for the management of erectile dysfunction and cardiovascular disease. Mayo Clin Proc. 2012; 87 (8): 766–78. DOI: 10.1016/j.mayocp.2012.06.015
  6. Petrova E., Gertsog N., Baranova G. i dr. Vzaimno potentsirujuschaja triada: depressija, erektil'naja disfunktsija i serdechno-sosudistaja patologija u muzhchin. Vrach. 2019; 30 (12): 3–6 [Petrova E., Herzog N., Baranova G. et al. Mutually reinforcing triad: depression, erectile dysfunction and cardiovascular pathology in men. Vrach. 2019; 30 (12): 3–6 (in Russ.)]. DOI: 10.29296/25877305-2019-12-01
  7. Lunenfeld B., Mskhalaya G., Zitzmann M. et al. Recommendations on the diagnosis, treatment and monitoring of hypogonadism in men. Aging Male. 2015; 18 (1): 1–11. DOI: 10.3109/13685538.2015.1004049
  8. Pushkar' D.Ju., Kamalov A.A., Al'-Shukri S.H. i dr. Analiz rezul'tatov epidemiologicheskogo issledovanija rasprostranennosti erektil'noj disfunktsii v Rossijskoj Federatsii. Urologija. 2012; 6: 5–9 [Pushkar D.Yu., Kamalov A.A., Al-Shukri S.Kh. et al. Analysis of the results of epidemiological study on prevalence of erectile dysfunction in the Russian Federation. Urologiya. 2012; 6: 5–9 (in Russ.)].
  9. Arutjunov G.P. i dr. Fundamental'nye i prikladnye aspekty mochegonnoj terapii. Ucheb. posob. M.: OOO «KlinMed Konsalting», 2018; 200 s. [Arutyunov G.P. et al. Fundamental’nye i prikladnye aspekty mochegonnoj terapii. Ucheb. posob. M.: OOO «KlinMed Konsalting», 2018; 200 s. (in Russ.)].
  10. Bubnova M.G., Aronov D.M. Serdechno-sosudistye zabolevanija, kardioreabilitatsija i seksual'naja aktivnost'. Chast' I: obschie rekomendatsii, fizicheskie trenirovki i serdechno-sosudistye preparaty. KardioSomatika. 2012; 3 (3): 70–81 [Bubnova M.G., Aronov D.M. Cardiovascular disease, cardiac rehabilitation and sexual activity. Part I: general recommendatoins, physical trainings, and cardiovascular agents. KardioSomatika. 2012; 3 (3): 70–81 (in Russ.)].
  11. Gupta B.P., Murad M.H., Clifton M.M. et al. The effect of lifestyle modification and cardiovascular risk factor reduction on erectile dysfunction: a systematic review and meta-analysis. Arch Intern Med. 2011; 171 (20): 1797–803. DOI: 10.1001/archinternmed.2011.440
  12. Rosen R.C., Riley A., Wagner G. et al. The international index of erectile function (IIEF): a multidimensional scale for assessment of erectile dysfunction. Urology. 1997; 49 (6): 822–30. DOI: 10.1016/S0090-4295(97)00238-0
  13. Bauer S.R. et al. Association of Diet With Erectile Dysfunction Among Men in the Health Professionals Follow-up Study. JAMA Netw Open. 2020; 3 (11): e2021701. DOI: 10.1001/jamanetworkopen.2020.21701
  14. Whittaker J., Wu K. Low-fat diets and testosterone in men: Systematic review and meta-analysis of intervention studies. J Steroid Biochem Mol Biol. 2021; 210: 105878. DOI: 10.1016/j.jsbmb.2021.105878
  15. Primenenie dieticheskogo i funktsional'nogo pitanija v lechebno-profilakticheskih i reabilitatsionnyh programmah. Klinicheskie rekomendatsii. 2015; 80 s. [Primenenie dieticheskogo i funkcional’nogo pitaniya v lechebno-profilakticheskih i reabilitacionnyh programmah. Klinicheskie rekomendacii. 2015; 80 s. (in Russ.)].
  16. Bubnova M.G., Aronov D.M. Serdechno-sosudistye zabolevanija, kardioreabilitatsija i seksual'naja aktivnost'. Chast' II. Chastnye voprosy i ingibitory fosfodiesterazy tipa 5. KardioSomatika. 2012; 3 (4): 55–64 [Bubnova M.G., Aronov D.M. Cardiovascular diseases, cardiac rehabilitation, and sexual activity. Part II. Particular issues and phosphodiesterase type 5 inhibitors. KardioSomatika. 2012; 3 (4): 55–64 (in Russ.)].
  17. Registr lekarstvennyh sredstv Rossii (RLS). Entsiklopedija lekarstv 2021. Vypusk 29. Pod red. G.L. Vyshkovskogo. M.: VEDANTA, 2020; 1456 s. [Registr lekarstvennyh sredstv Rossii (RLS). Enciklopediya lekarstv 2021. Vypusk 29. Pod red. G.L. Vyshkovskogo. M.: VEDANTA, 2020; 1456 s. (in Russ.)].
  18. Traish A.M. et al. Long-term testosterone therapy in hypogonadal men ameliorates elements of the metabolic syndrome: an observational, long-term registry study. Int J Clin Pract. 2014; 68 (3): 314–29. DOI: 10.1111/ijcp.12319
  19. Labazi H., Wynne B.M., Tostes R. et al. Metformin treatment improves erectile function in an angiotensin II model of erectile dysfunction. J Sex Med. 2013; 10 (9): 2154–64. DOI: 10.1111/jsm.12245
  20. Barassi A., Pezzilli R., Colpi G.M. et al. Vitamin D and erectile dysfunction. J Sex Med. 2014; 11: 2792–800. DOI: 10.1111/jsm.12661
  21. Tjuzikov I.A., Kalinchenko S.Ju., Vorslov L.O. i dr. Vitamin D, muzhskoe zdorov'e i muzhskaja reproduktsija. Andrologija i genital'naja hirurgija. 2013; 4: 36–44 [Tyuzikov I.A., Kalinchenko S.Yu., Vorslov L.O. et al. Vitamin D, men’s health and male reproduction. Andrology and Genital Surgery. 2013; 14 (4): 36–44 (in Russ.)]. DOI: 10.17650/2070-9781-2013-4-36-44
  22. Kidir V., Altuntas A., Inal S. et al. Sexual dysfunction in dialysis patients: does vitamin D deficiency have a role? Int J Clin Exp Med. 2015; 8 (12): 22491–6.
  23. Defitsit vitamina D u vzroslyh: diagnostika, lechenie i profilaktika. Klinicheskie rekomendatsii. 2016; 39 s. [Deficit vitamina D u vzroslyh: diagnostika, lechenie i profilaktika. Klinicheskie rekomendacii. 2016; 39 s. (in Russ.)].
  24. Dreval' A.V., Krjukova I.V., Barsukov I.A. i dr. Vnekostnye effekty vitamina D (obzor literatury). RMZh. 2017; 1: 53–6 [Dreval’ A.V., Kryukova I.V., Barsukov I.A. et al. Extra-osseous effects of vitamin D (a review). RMJ. 2017; 1: 53–6 (in Russ.)].
  25. Petrova E.V., Vakina T.N., Burmistrova L.A. Seksual'nye disfunktsii pri trevozhno-depressivnyh rasstrojstvah. Lechaschij vrach. 2014; 5: 108–11 [Petrova E.V., Vakina T.N., Burmistrova L.A. Sexual dysfunction in anxiety and depressive disorders. Lechashchii vrach. 2014; 5: 108–11 (in Russ.)].
  26. Mitrofanov D.V., Budnikova N.V., Burmistrova L.A. Optimal'nyj sostav adsorbenta dlja stabilizatsii trutnevogo rasploda. Pchelovodstvo. 2017; 10: 48–9 [Mitrofanov D.V., Budnikova N.V., Burmistrova L.A. The optimized composition of the adsorbent for stabilization of the drone brood. Pchelovodstvo. 2017; 10: 48–9 (in Russ.)].
  27. Petrova E., Elistratov D. Terapevticheskaja korrektsija erektil'noj disfunktsii i trevozhno-depressivnyh rasstrojstv u patsientov s arterial'noj gipertenziej. Vrach. 2016; 4: 78–81 [Petrova E., Elistratov D. Therapeutic correction of erectile dysfunction and anxiety and depressive disorders in hypertensive patients. Vrach. 2016; 4: 78–81 (in Russ.)].
  28. Farmakoterapija u lits pozhilogo i starcheskogo vozrasta. Metodicheskie rukovodstva. 2018; 87 s. [Farmakoterapiya u lic pozhilogo i starcheskogo vozrasta. Metodicheskie rukovodstva. 2018; 87 s. (in Russ.)].