Impact on the quality of life of the features of calcium-phosphorus relationships in tumor growth in old age

DOI: https://doi.org/10.29296/25877305-2021-06-15
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Issue: 
6
Year: 
2021

Professor T. Pavlova, MD; E. Malyutina, Candidate of Medical Sciences; D. Bessmertnyi,
Candidate of Medical Sciences; V. Novikov, Candidate of Engineering Sciences; I. Pavlov, Candidate of
Medical Sciences; V. Markovskaya, Candidate of Biological Sciences; O. Varavin Belgorod State National
Research University

The quality of life in oncological pathology is an important criterion for the effectiveness of the treatment. One of the key issues is the change in metabolism in the elderly and senile age. This aspect is directly related to the state of the elements. The age-related pathology can also include endocrinopathies, including those with oncological pathology of the endocrine organs. The aim of the study was to develop new approaches to the study of age-associated disorders in individuals with cancer pathology with the study of phosphorus-calcium relationships for their further correction with the goal of improving the quality of life of such patients. We selected 40 cases of prostate adenocarcinoma of the 2nd and 3rd degree in middle-aged and elderly people and 47 cases of papillary thyroid cancer. A clinical and pathomorphological study of the removed thyroid and pancreas was performed (macroscopic, microscopic, electron microscopic in a scanning microscope «FE1 Quanta 200 3D» with a matched detector for the study of elemental analysis). When studying the biochemical atypism in pancreatic and thyroid cancers using point analysis of elements, it was shown that in the areas of accumulation of tumor cells, there was an increase in the content of both calcium and phosphorus, which decreases as they move away from them. Given that their content is higher in the elderly groups and atypical cells are not always identified next to them, it seems that their formation may be primary. The presence of histochemical atypism in the glands can cause the development of paraneoplastic syndromes, in particular, increased osteoporosis in the elderly and a number of other signs. All this should be taken into account when correcting such conditions in order to improve the quality of life.

Keywords: 
quality of life
geriatrics
oncology
elements
endocrinopathy



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References: 
  1. Pavlova T.V., Kulikovsky V.F., Pavlov I.A. et al. Features of Blood in Oncourological Pathology. Indo Am J Pharm Sci (IAJPS). 2018; 5 (7): 7014–20. DOI: 10.5281/zenodo.1324393
  2. Kaprin A.D., Starinskij V.V., Petrova G.V. Sostojanie onkologicheskoj pomoschi naseleniju Rossii v 2018 godu. M.: MNIOI im. P.A. Gertsena – filial FGBU «NMITs radiologii» Minzdrava Rossii, 2019; 236 s. [Kaprin A.D., Starinskii V.V., Petrova G.V. Sostoyanie onkologicheskoi pomoshchi naseleniyu Rossii v 2018 godu. M.: MNIOI im. P.A. Gertsena – filial FGBU «NMITs radiologii» Minzdrava Rossii, 2019; 236 s. (in Russ.)].
  3. Soloviev A.G., Popov V.V., Novikova I.A. Diagnosis of disorders of the emotional sphere in older persons. Advances in Gerontology. 2016; 6 (3): 249–59. DOI: 10.1134/s2079057016030140
  4. Zherko L.V. Osobennosti fosforno-kal'tsievogo obmena u patsientov s differentsirovannoj kartsinomoj schitovidnoj zhelezy. Molodoj uchenyj. 2016; 19 (123): 147–9 [Zherko L.V. Osobennosti fosforno-kal’tsievogo obmena u patsientov s differentsirovannoi kartsinomoi shchitovidnoi zhelezy. Molodoi uchenyi. 2016; 19 (123): 147–9 (in Russ.)].
  5. Leonova T.A. Reabilitatsija patsientov s kartsinomoj schitovidnoj zhelezy na fone osobennostej fosforno-kal'tsievogo obmena. Pod red. V.M. Drozd i dr. Minsk: Izdatel'stvo Belorusskij komitet «Dzetsi Charnobylja», 2010; s. 57–73 [Leonova T.A. Reabilitatsiya patsientov s kartsinomoi shchitovidnoi zhelezy na fone osobennostei fosforno-kal’tsievogo obmena. Pod red. V.M. Drozd et al. Minsk: Izdatel’stvo Belorusskii komitet «Dzetsi Charnobylya», 2010; s. 57–73 (in Russ.)].
  6. Pavlova T.V., Kulikovskij V.F., Pil'kevich N.B. i dr. Patogeneticheskie aspekty elementozov pri onkologicheskoj patologii vydelitel'noj sistemy. Vrach. 2020; 31 (11): 50–4 [Pavlova T., Kulikovsky V., Pilkevich N. et al. Elementoses in excretory system cancer: pathogenetic aspects. Vrach. 2020; 31 (11): 50–4 (in Russ.)]. DOI: 10.29296/25877305-2020-11-09
  7. Pavlova T.V., Pilkevich N.B., Petrukhin V.A. et al. New Approaches to the Study of Elementosis in Obstetrics. Journal of International Pharmaceutical Research. 2019; 276–80.
  8. Chernova D.N. Vlijanie personalizirovannoj korrektsii elementnogo statusa na immunnuju funktsiju cheloveka. Mikroelementy v meditsine. 2018; 4: 49–51 [Chernova L.N. Effects of personalized correction of trace element status on human immune function. Mikroelementy v meditsine. 2018; 4: 49–51 (in Russ.)]. DOI: 10.19112/2413-6174-2017-18-49-51
  9. Buevich N.N., Protsenko S.A., Nosov A.K. i dr. Problema vybora taktiki vedenija patsientov s vysokim i ochen' vysokim riskom raka predstatel'noj zhelezy: obzor literatury. Onkourologija. 2019; 15 (1): 117–24 [Buevich N.N., Protsenko S.A., Nosov A.K. et al. The problem of choosing the tactics of managing patients with high and very high risk of prostate cancer: a review of the literature. Cancer Urology. 2019; 15 (1): 117–24 (in Russ.)]. DOI: 10.17650/1726-9776-2019-15-1-117-124
  10. Zjablov E.V., Chesnokova N.P., Barsukov V.Ju. Rak schitovidnoj zhelezy: sovremennye kontseptsii etiologii i patogeneza. Nauchnoe obozrenie. Meditsinskie nauki. 2016; 3: 37–61 [Zyablov E.V., Chesnokov N.P., Barsukov V.Yu. Thyroid cancer: modern concepts of etiology and pathogenesis. Nauchnoe obozrenie. Meditsinskie nauki. 2016; 3: 37–61 (in Russ.)].
  11. Habarov O.R., Bezrukov O.F., Zima D.V. Rak schitovidnoj zhelezy u lits pozhilogo i starcheskogo vozrasta. Aktual'nye voprosy sovremennoj meditsiny i geriatrii: mat-ly VII mezhregion. nauch.-prakt. geriatricheskoj konf. 2016; s. 248–50 [Khabarov O.R., Bezrukov O.F., Zima D.V. Rak shchitovidnoi zhelezy u lits pozhilogo i starcheskogo vozrasta. Aktual’nye voprosy sovremennoi meditsiny i geriatrii: mat-ly VII mezhregion. nauch.-prakt. geriatricheskoi konf. 2016; s. 248–50 (in Russ.)].
  12. Kitahara C.M., Sosa J.A. The changing incidence of thyroid cancer. Nat Rev Endocrinol. 2016; 12 (11): 646–53. DOI: 10.1038/nrendo.2016.110