The use of the regulatory polypeptide Selank and combined phototherapy to enhance the efficiency of treatment in patients with atopic dermatitis
DOI: https://doi.org/10.29296/25877305-2020-11-06
Issue:
11
Year:
2020
In view of the insufficient efficiency of the currently known procedures to treat patients with
atopic dermatitis (AD), there is a need to search for new approaches to solving this problem. Objective: to
elaborate a therapeutic approach to treating patients with AD on the basis of combination use along with
basic agents, as well as a drug from the group of regulatory peptides (such as Selank) and combined
phototherapy (CPT). Subjects and methods. A group of 124 patients (mean age, 23.70±6.06 years) underwent a
comparative evaluation of the efficiency of basic drug therapy (BDT) for AD, by additionally using the
regulatory polypeptide Selank and CPT (narrowband medium-wave and broadband long-wave radiation (UVB-311
nm/UVA-320-400 nm)), as well as combinations thereof. Results. The combined use of BDT, Selanka, and CPT
revealed the potentiation of the clinical effects of the therapeutic procedures used. At 1-year follow-up,
the relative risk reduction in disease recurrence was 36% in the Selank + BDT group, 42% in the CPT + BDT
group, and 78% in the Selank + CPT + BDT group, as compared to the BDT group. Conclusion. The developed
treatment option provides the most effective reduction (78.8%) in the severity of cutaneous manifestations
of AD, as shown by the SCORAD index, a 64.7% improvement in quality of life, and a 78% relative risk
reduction in disease recurrence, as compared to BDT results.
Keywords:
dermatology
therapy
atopic dermatitis
Selank
combined phototherapy
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