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Efficacy of non-invasive ammonium test in diagnostic of Helicobacter pylori infection in patient with dyspepsia

DOI: https://doi.org/10.29296/25877305-2020-10-10
Issue: 
10
Year: 
2020

N. Baryshnikova, Candidate of Medical Sciences, Associate Professor Acad. I.P. Pavlov First
Saint Petersburg State Medical University Institute of Experimental Medicine, Saint Petersburg

Detection of Helicobacter pylori (Hp) is mandatory examination for all patients with dyspepsia. An option for cost-effective non-invasive diagnosis of H. pylori infection is the HELIC® ammonium test (Association of Medicine and Analytics, St. Petersburg, Russia), based on the detection of ammonia (the second product of urea hydrolysis by Hp urease) in exhaled air in oral cavity. Material and methods. Three studies were conducted to assess the effectiveness of this test: 1. Evaluation of ammonia level increase in exhaled air before examination (basal level) and after direct infusion of 50 ml of 1% urea solution into stomach during endoscopic examination (loading level). In study, histological examination of stomach body and antrum biopsies was a reference comparison method. 2. Comparison of ammonium test results and histological method by independent researchers in different countries, 3. Analysis of the sensitivity and specificity of the ammonium test by independent researchers in different countries. Results. Eight patients out of nine with histologically confirmed Hp responded with a significant (p

Keywords: 
gastroenterology
Helicobacter pylori
ammonium test
non-invasive diagnostic



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