The Journal is included in Russian and International Library and Abstract Databases
Russain Science Index (Russia)
EBSCO
DOI Registration Agency (USA)

The role of diabetes mellitus and a gender factor in the development of a second noncardioembolic ischemic stroke

DOI: https://doi.org/10.29296/25877305-2020-10-09
Issue: 
10
Year: 
2020

V. Shishkova(1, 2), Candidate of Medical Sciences; Professor T. Adasheva(2), MD; Professor L.
Stakhovskaya(3), MD (1)Center for Speech Pathology and Neurorehabilitation, Moscow Healthcare Department
(2)A.I. Evdokimov Moscow State University of Medicine and Dentistry, Ministry of Health of Russia (3)N.I.
Pirogov Russian National Research Medical University, Moscow

Objective. To analyze the frequency and date of onset of a secondary noncardioembolic ischemic stroke (IS) over a three-year period according to a patient’s gender and the presence of diabetes mellitus (DM). Subjects and methods. The cohort observational study covered 206 patients who had experienced a first noncardioembolic IS. The clinical and metabolic parameters were studied in the participants, as well as the frequency and date of onset of a secondary IS were assessed using the Cutler-Ederer and Kaplan-Meier methods according to gender and DM. Results. The analysis of the frequency and date of onset of a second noncardioembolic IS over a three-year period showed an increase in the risk of this pathology in both male patients and type 2 diabetes (T2DM) ones. Conclusion. Male patients and T2DM ones are at a high risk for a secondary noncardioembolic IS.

Keywords: 
neurology
endocrinology
non-cardioembolic ischemic stroke
diabetes mellitus
male sex



References: 
  1. Stahovskaja L.V., Kotov S.V., Isakova E.V. Insul't: rukovodstvo dlja vrachej. M.: OOO «Meditsinskoe informatsionnoe agentstvo», 2013; 400 s. [Stakhovskaya L.V., Kotov S.V., Isakova E.V. Insul’t: rukovodstvo dlya vrachei. M.: OOO «Meditsinskoe informatsionnoe agentstvo», 2013; 400 s. (in Russ.)].
  2. Hewitt J., Castilla G.L., Fernández-Moreno M.C. et al. Diabetes and stroke prevention: a review. Stroke Res Treat. 2012; 2012: 673187. DOI: 10.1155/2012/673187
  3. Gibson C.L. Cerebral ischemic stroke: is gender important? J Cereb Blood Flow Metab. 2013; 33 (9): 1355–61. DOI: 10.1038/jcbfm.2013.102
  4. Giralt D., Domingues-Montanari S., Mendioroz M. et al. The gender gap in stroke: a meta-analysis. Acta Neurol Scand. 2012; 125 (2): 83–90. DOI: 10.1111/j.1600-0404.2011.01514.x
  5. Shishkova V.N., Adasheva T.V., Remennik A.Ju. i dr. Prognosticheskaja znachimost' kliniko-antropometricheskih, biohimicheskih, metabolicheskih, sosudisto-vospalitel'nyh i molekuljarno-geneticheskih markerov v razvitii pervogo ishemicheskogo insul'ta. Zhurnal nevrol. i psihiatr. im. S.S. Korsakova. 2018; 118 (2): 4–11 [Shishkova V.N., Adasheva T.V., Remenik A.Yu. et al. Prognostic significance of clinical-anthropometric, biochemical, metabolic, vascular-inflammatory and molecular-genetic markers in the development of the first ischemic stroke. S.S. Korsakov Journal of Neurology and Psychiatry = Zhurnal nevrologii i psikhiatrii imeni S.S. Korsakova. 2018; 118 (2): 4–11 (in Russ.)]. https://doi.org/10.17116/jnevro2018118214-11
  6. Chen R., Ovbiagele B., Feng W. Diabetes and stroke: epidemiology, pathophysiology, pharmaceuticals and outcomes. Am J Med Sci. 2016; 351 (4): 380–6. DOI: 10.1016/j.amjms.2016.01.011