Prevention of osteoporotic fractures in the elderly

DOI: https://doi.org/10.29296/25877305-2020-09-04
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Issue: 
9
Year: 
2020

S. Bulgakova, MD; E. Treneva, Candidate of Medical Sciences; Professor N. Zakharova, MD; P.
Romanchuk, Candidate of Medical Sciences Samara State Medical University

Osteoporosis by medical and social significance is in fourth place among noncommunicable diseases. Fractures often have a multifactorial nature. Prevention of fractures in the elderly consists of the prophylaxis and drug therapy of low bone density, the prevention of falls using regular physical exercises, the organization of a safe environment, the correction of treatment regimens for concomitant diseases, excluding drugs that increase the risk of falls, giving up bad habits (smoking, alcohol), balanced nutrition. In a review of the literature, primary and secondary prophylaxis of fractures in the elderly using pharmacological and nonpharmacological agents is considered.
Keywords: 
geriatrics
falls
elderly people
fractures
lifestyle
osteoporosis
prevention

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References: 
  1. Nakasato Y., Raymond L. Yung Geriatric Rheumatology. A Comprehensive Approach. 2011; 330 r.
  2. Fares A. Pharmacological and Non-pharmacological Means for Prevention of Fractures among Elderly. Int J Prev Med. 2018; 9: 78. DOI: 10.4103/ijpvm.IJPVM_114_18
  3. Compston J., Cooper A., Cooper C. et al. UK clinical guideline for the prevention and treatment of osteoporosis. Arch Osteoporos. 2017; 12 (1): 43. DOI: 10.1007/s11657-017-0324-5
  4. Wang J., Wang X., Fang Z. et al. The effect of FRAX on the prediction of osteoporotic fractures in urban middle-aged and elderly healthy Chinese adults. Clinics (Sao Paulo). 2017; 72: 289–93. DOI: 10.6061/clinics/2017(05)06
  5. Bulgakova S. V., Romanchuk N. P. Polovye gormony i kognitivnye funktsii: sovremennye dannye. Bjulleten' nauki i praktiki. 2020; 6 (3): 69–95 [Bulgakova S., Romanchuk R. Sex Hormones and Cognitive Functions: Current Data. Bulletin of Science and Practice. 2020; 6 (3): 69–95 (in Russ.)]. DOI: 10.33619/2414-2948/52/09
  6. Bulgakova S.V., Romanchuk P.I., Treneva E.V. Insulin, golovnoj mozg, bolezn' Al'tsgejmera: novye dannye. Bjulleten' nauki i praktiki. 2020; 6 (3): 96–126 [Bulgakova S., Romanchuk P., Treneva E. Insulin, Brain, Alzheimer’s Disease: New Evidence. Bulletin of Science and Practice. 2020; 6 (3): 96–126 (in Russ.)]. DOI: 10.33619/2414-2948/52/10
  7. Avenell A., Mak J.C., O’Connell D. Vitamin D and vitamin D analogues for preventing fractures in post-menopausal women and older men. Cochrane Database Syst Rev. 2014; 4: CD000227. DOI: 10.1002/14651858.CD000227.pub4
  8. Avenell A., Mak J.C., O’Connell D. Vitamin D and vitamin D analogues for preventing fractures in post-menopausal women and older men. Cochrane Database Syst Rev. 2014; 4: CD000227. DOI: 10.1002/14651858.CD000227.pub4
  9. Tang B.M., Eslick G.D., Nowson C. et al. Use of calcium or calcium in combination with vitamin D supplementation to prevent fractures and bone loss in people aged 50 years and older: A meta-analysis. Lancet. 2007; 370: 657–66. DOI: 10.1016/S0140-6736(07)61342-7
  10. Harvey N.C., Biver E., Kaufman J.M. et al. The role of calcium supplementation in healthy musculoskeletal ageing: An expert consensus meeting of the European Society for Clinical and Economic Aspects of Osteoporosis, Osteoarthritis and Musculoskeletal Diseases (ESCEO) and the International Foundation for Osteoporosis (IOF). Osteoporos Int. 2017; 28: 447–62. DOI: 10.1007/s00198-016-3773-6
  11. Byun J.H., Jang S., Lee S. et al. The efficacy of bisphosphonates for prevention of osteoporotic fracture: An update meta-analysis. J Bone Metab. 2017; 24: 37–49. DOI: 10.11005/jbm.2017.24.1.37
  12. Zhou J., Wang T., Zhao X. et al. Comparative efficacy of bisphosphonates to prevent fracture in men with osteoporosis: A systematic review with network meta-analyses. Rheumatol Ther. 2016; 3: 117–28. DOI: 10.1007/s40744-016-0030-6
  13. Wells G.A., Cranney A., Peterson J. et al. Alendronate for theprimary and secondaryprevention of osteoporotic fractures in postmenopausal women. Cochrane Database Syst Rev. 2008; 1: CD001155. DOI: 10.1002/14651858.CD001155.pub2
  14. Chesnut C.H., Silverman S., Andriano K. et al. PROOF Study Group. A randomized trial of nasal spray salmon calcitonin in postmenopausal women with established osteoporosis: The prevent recurrence of osteoporotic fractures study. Am J Med. 2000; 109: 267–76. DOI: 10.1016/s0002-9343(00)00490-3
  15. Wells G., Chernoff J., Gilligan J.P. et al. Does salmon calcitonin cause cancer? A review and meta-analysis. Osteoporos Int. 2016; 27: 13–9. DOI: 10.1007/s00198-015-3339-z
  16. Torgerson D.J., Bell-Syer S.E. Hormone replacement therapy and prevention of non-vertebral fractures: A meta-analysis of randomized trials. JAMA. 2001; 285: 2891–7. DOI: 10.1001/jama.285.22.2891
  17. Torgerson D.J., Bell-Syer S.E. Hormone replacement therapy and prevention of vertebral fractures: A meta-analysis of randomized trials. BMC Musculoskelet Disord. 2001; 2: 7. DOI: 10.1186/1471-2474-2-7
  18. Fujiwara S., Hamaya E., Sato M. et al. Systematic review of raloxifene in postmenopausal Japanese women with osteoporosis or low bone mass (osteopenia). Clin Interv Aging. 2014; 9: 1879–93. DOI: 10.2147/CIA.S70307
  19. Cummings S.R., Ensrud K., Delmas P.D. et al. Lasofoxifene in postmenopausal women with osteoporosis. N Engl J Med. 2010; 362: 686–96. DOI: 10.1056/NEJMoa0808692
  20. Palacios S., Silverman S.L., de Villiers T.J. et al. Bazedoxifene Study Group. A 7-year randomized, placebo-controlled trial assessing the long-term efficacy and safety of bazedoxifene in postmenopausal women with osteoporosis: Effects on bone density and fracture. Menopause. 2015; 22: 806–13. DOI: 10.1097/GME.0000000000000419
  21. Santesso N., Carrasco-Labra A., Brignardello-Petersen R. Hip protectors for preventing hip fractures in older people. Cochrane Database Syst Rev. 2014; 3: CD001255. DOI: 10.1002/14651858.CD001255.pub5
  22. Bulgakova S.V. Rannjaja diagnostika i lechebno-profilakticheskie meroprijatija u lits starshih vozrastnyh grupp dlja predotvraschenija osteoporoticheskih perelomov. Dis. ... d-ra med. nauk. Samara, 2011; 401 s. [Bulgakova S. Early diagnosis and treatment in people of older age groups to prevent osteoporotic fractures. Dis. ... d-ra med. nauk. Samara, 2011; 401 s. (in Russ.)]
  23. Kujala U.M., Kaprio J., Kannus P. et al. Physical activity and osteoporotic hip fracture risk in men. Arch Intern Med. 2000; 160: 705–8. DOI: 10.1001/archinte.160.5.705
  24. Cadore E.L., Rodriguez-Mañas L., Sinclair A. et al. Effects of different exercise interventions on risk of falls, gait ability, and balance in physically frail older adults: A systematic review. Rejuvenation Res. 2013; 16: 105–14. DOI: 10.1089/rej.2012.1397
  25. Bauman A., Merom D., Bull F.C. et al. Updating the Evidence for physical activity: summative reviews of the epidemiological evidence, prevalence, and interventions to promote «active aging». Gerontologist. 2016; 56 (Suppl. 2): S268–80. DOI: 10.1093/geront/gnw031
  26. Fiatarone M.A., O’Neill E.F., Ryan N.D. et al. Exercise training and nutritional supplementation for physical frailty in very elderly people. N Engl J Med. 1994; 330 (25): 1769–75. DOI: 10.1056/NEJM199406233302501
  27. Lustosa L.P., Silva J.P., Coelho F.M. et al. Impact of resistance exercise program on functional capacity and muscular strength of knee extensor in pre-frail community-dwelling older women: A randomized crossover trial. Rev Bras Fisioter. 2011; 15: 318–24.
  28. Luo S.Y., Li Y., Luo H. et al. Increased intake of vegetables, but not fruits, may be associated with reduced risk of hip fracture: A meta-analysis. Sci Rep. 2016; 6: 19783. The practice (implementation). DOI: 10.1038/srep19783
  29. Hernandez-Avila M., Colditz G.A., Stampfer M.J. et al. Caffeine, moderate alcohol intake, and risk of fractures of the hip and forearm in middle-aged women. Am J Clin Nutr. 1991; 54: 157–63. DOI: 10.1093/ajcn/54.1.157
  30. Wu Z.J., Zhao P., Liu B. et al. Effect of cigarette smoking on risk of hip fracture in men: A meta-analysis of 14 prospective cohort studies. PLoS One. 2016; 30: 11. DOI: 10.1371/journal.pone.0168990
  31. Rosen T., Mack K.A., Noonan R.K. Slipping and tripping: Fall injuries in adults associated with rugs and carpets. J Inj Violence Res. 2013; 5: 61–9. DOI: 10.5249/jivr.v5i1.177
  32. Hill A.M., Francis-Coad J., Haines T.P. et al. «My independent streak may get in the way»: How older adults respond to falls prevention education in hospital. BMJ Open. 2016; 6: e012363. http://dx.doi.org/10.1136/bmjopen-2016-012363
  33. Nikitin O.L., Romanchuk P.I., Bulgakova S.V. i dr. Sposob uvelichenija mineral'noj plotnosti kostnoj tkani. Patent RF na izobretenie №2481815 ot 20.05.13 [Nikitin O., Romanchuk P., Bulgakova S. et al. A method of increasing the mineral density of bone. RF patent for invention №2481815 20.05.13 (in Russ.)].