THE USE OF THYMALINE TO CORRECT IMMUNE STATUS DEVIATIONS IN COVID-19 (rationale for the use of drug and clinical case)
DOI: https://doi.org/10.29296/25877305-2020-08-12
Issue:
8
Year:
2020
Data on violations of cellular and humoral immunity in severely patients with COVID-19, as well as
the hemostatic system were summarized. It has been shown that patients with COVID-19 have leukocytopenia,
lymphocytopenia, neutrophilia, as well as a violation of the ratio between individual subpopulations of
T-lymphocytes. The content of pro-inflammatory cytokines increases significantly, which leads to the
development of a «cytokine storm». At the same time, such patients develop endothelial dysfunction,
hypercoagulation, accompanied by an increase in D-dimer with the subsequent development of microangiopathy
(MAP), immunothrombosis, disseminated intravascular coagulation (DIC) and multiple organ failure. A case is
given of the use of an immunocorrector thymalin in a patient with a severe course of COVID-19, which
contributes to the elimination of disorders in the immune system (including «cytokine storm») and
hemostasis.
Keywords:
therapy
infectious diseases
COVID-19
immunity
«cytokine storm»
blood clotting
multiple organ failure
thymalin
heparin
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