Early manifestations of primary knee osteoarthrosis: immunological aspects

DOI: https://doi.org/10.29296/25877305-2020-03-18
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Issue: 
3
Year: 
2020

S. Belova(1), Biol.D; E. Gladkova(1), Candidate of Biological Sciences; R. Zubavlenko(2); V. Ulyanov(1), MD (1)Research Institute of Traumatology, Orthopedics, and Neurosurgery, V.I. Razumovsky Saratov State Medical University (2)V.I. Razumovsky Saratov State Medical University

Objective: to evaluate immunological changes in patients with primary knee osteoarthrosos (OA) at an early stage of its development. Subjects and methods. The patients underwent clinical, instrumental (ultrasonography, X-ray, and magnetic resonance imaging of the knee joints), and laboratory examination that involved the assessment of cartilage tissue metabolism, activity of an inflammatory response, and the immune system. Results. The patients showed increases in the serum concentration of cartilage oligomeric matrix protein and in the production of the proinflammatory cytokines interleukin (IL-1β, tumor necrosis factor-α, and IL-6), as well as changes in the qualitative and quantitative composition of peripheral blood lymphocyte subpopulations (T and B lymphocytes, natural killer cells). Conclusion. The study of the immunological aspects of primary knee OA at an early stage of its development showed the activation of proinflammatory cytokines along with a certain change in the cellular component of immunity, which determines an autoimmune response that creates conditions for the development of an inflammatory process that entails degenerative and dystrophic phenomena in the joint tissues. This is confirmed by the elevated serum level of cartilage oligomeric matrix protein. The results of the study can be useful for the objective assessment of these patients’ condition and for the prescription of immunomodulatory and chondroprotective drugs just at an early stage of the disease.
Keywords: 
ревматология
остеоартроз
иммунологические изменения

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References: 
  1. Samorodskaja I., Bazina I. Sovremennye predstavlenija o diagnostike i lechenii osteoartroza // Vrach. – 2015; 5: 2–6 [Samorodskaya I., Bazina I. Current ideas on the diagnosis and treatment of osteoarthrosis // Vrach. – 2015; 5: 2–6 (in Russ.)].
  2. Makushin V.D., Chegurov O.V. Gonartroz (voprosy patogeneza i klassifikatsii) // Genij Ortopedii. – 2005; 2: 19–22 [Makushin V.D., Chegourov O.K. Gonarthrosis (the problems of pathogenesis and classification) // Genij Ortopedii. – 2005; 2: 19–22 (in Russ.)].
  3. Badokin V.V. Osteoartroz kolennogo sustava: klinika, diagnostika, lechenie // Sovremennaja revmatologija. – 2013; 7 (3): 70–5 [Badokin V.V. Knee osteoarthrosis: Clinical presentation, diagnosis, treatment // Modern Rheumatology Journal. – 2013; 7 (3): 70–5 (in Russ.)]. DOI: 10.14412/1996-7012-2013-277
  4. EULAR Compendium on Rheumatic Disease. Ed. J. Bijsma / London: BMJ Publishing, 2009; 824 p.
  5. Chepeleva M.V., Chegurov O.K., Kuznetsova E.I. Kontsentratsii tsitokinov v perifericheskoj krovi i sinovial'noj zhidkosti patsientov s deformirujuschim osteoartrozom kolennogo sustava v zavisimosti ot velichiny defekta vnutrennego myschelka bol'shebertsovoj kosti // Genij ortopedii. – 2017; 23 (4): 450–4 [Chepeleva M.V., Chegurov O.K., Kuznetsova E.I. Cytokine concentration in peripheral blood and synovium in patients with deforming arthritis of the knee with regard to defect size of the medial tibial condyle // Genij Ortopedii. – 2017; 23 (4): 450–4 (in Russ.)]. DOI: 10.18019/1028-4427-2017-23-4-450-454
  6. Takayanagi H. Inflammatory bone destruction and osteoimmunology // J. Periodontal. Res. – 2005; 40 (4): 287–93. DOI: 10.1111/j.1600-0765.2005.00814.x
  7. Shevchenko N.S., Lebets I.S., Nelina I.N. i dr. Patogeneticheskaja znachimost' vospalenija pri osteoartroze u podrostkov s initsial'nymi stadijami // Ukrains'kij revmatologichnij zhurnal. – 2010; 39 (1): 50–4 [Shevchenko N.S., Lebets I.S., Nelina I.N. et al. Pathogenetic role of the inflammationin osteoarthritis adolescents patients with initial disease stages // Ukrainskij revmatologicheskij zhurnal. – 2010; 39 (1): 50–4 (in Russ.)].
  8. Chepeleva M.V. Vlijanie hirurgicheskogo lechenija na immunnyj status bol'nyh osteoartrozom kolennogo i tazobedrennogo sustavov. Avtoref. ... kandid. med. nauk. Kurgan, 2007; 23 s. [Chepeleva M.V. Vliyanie hirurgicheskogo lecheniya na immunnyj status bol’nyh osteoartrozom kolennogo i tazobedrennogo sustavov. Avtoref. ... kand. med. nauk. Kurgan, 2007; 23 s. (in Russ.)].
  9. Gnilorybov A.M., Hreschakova T.P. Rol' oligomernogo matriksnogo proteina hrjascha v diagnostike porazhenija sustavov // Ukrains'kij revmatologichnij zhurnal. – 2004; 17 (3): 8–11 [Gnilorybov A.M., Khreschakova T.P. The role of cartilage oligomeric matrix protein (SOMR) in diagnostics of arthropathy // Ukrainskij revmatologicheskij zhurnal. – 2004; 17 (3): 8–11 (in Russ.)].
  10. Belova Ju.S. Karjakina E.V. Hrjaschevoj protein pri razlichnyh tipah displazii // RMZh. – 2017; 19: 1352–5 [Belova Yu.S., Karyakina E.V. Sartilage oligometric matrix protein in various types of dysplasia // RMJ. – 2017; 19: 1352–5 (in Russ.)].
  11. Hecht J., Makitie O., Hayes E. et al. Chondrocyte cell death and intracellular distribution of COMP and type IX collagen in the pseudoachondroplasia growth plate // J. Orthop. Res. – 2004; 22 (4): 759–67. DOI: 10.1016/j.orthres.2003.11.010
  12. Posey K., Hecht J. The role of cartilage oligomeric matrix protein (COMP) in skeletal disease // Curr. Drug. Targets. – 2008; 9 (10): 869–77. DOI: 10.2174/138945008785909293
  13. Hidayat R., Isbagio H., Setyohadi B. et al. Correlation between receptor activator of nuclear factor-κβ ligand (RANKL), and osteoprotegerin (OPG) with cartilage degradation in rheumatoid arthritis patients // Acta Med. Indones. – 2014; 46 (1): 24–9.