The dynamics of the psychological status in Helicobacter pylori-infected patients when using different eradication therapy regimens

DOI: https://doi.org/10.29296/25877305-2020-01-10
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1
Year: 
2020

Professor Yu. Uspensky(1, 2), MD; Professor I. Gorbacheva(2), MD; N. Baryshnikova(2, 3), Candidate of Medical Sciences; S. Akaeva(2); A. Gnutov(1); M. Rustamov(4) (1)Saint Petersburg State Pediatric Medical University (2)Acad. I.P. Pavlov First Saint Petersburg State Medical University (3)Institute of Experimental Medicine, Saint Petersburg (4)Belarusian State Medical University, Minsk, Belarus

Objective: to evaluate the efficacy of probiotics in addition to standard treatment in improve the psychological status of patients with chronic gastroduodenitis (CGD) associated with Helicobacter pylori (Hp). Materials and methods: 75 patients underwent standard eradication therapy (SET): omeprazole 20 mg, amoxicillin 1000 mg, clarithromycin 500 mg BID for 7 days. Patients in group 1 (n=23) additionally received a biologically active supplement (BAS) with the probiotic mechanism Enterococcus faecium L-3 3 tablets TID for 4 weeks; patients in group 2 (n=32) – dietary supplements with the probiotic Bacillus subtilis in a dose of 2 capsules BID for 4 weeks; patients of the comparison group (n=20) – only SET. In addition to a complete gastroenterological examination and verification of Hp, patients underwent a psychological examination before and 1.5–2 months after treatment using special questionnaires to assess anxiety, depression, asthenia, and quality of life. Results: in both experimental groups there was a more significant improvement in the quality of life than in the comparison group (p
Keywords: 
gastroenterology
Helicobacter pylori
probiotics
anxiety
depression
asthenia
quality of life

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