Current approaches to rehabilitating children with gynecological cancer

DOI: https://doi.org/10.29296/25877305-2019-09-01
Issue: 
9
Year: 
2019

Professor A. Solopova, MD; A. Vlasina; Yu. Nikulenkova I.M. Sechenov First Moscow State Medical University (Sechenov University)

Recently, there has been a tendency to increase the incidence of cancer not only in the adult population, but also in the pediatric one. Studies of tumors in different patient age categories have shown significant differences in their localization, structure, rates, nature of development, clinical presentations, and possibilities for diagnosis and treatment of this group of diseases. Genital tumors in pediatric and adolescent girls are a rare and poorly studied condition. However, untimely and (or) improperly rendered medical care for female reproductive system cancers can lead to grave consequences, such as hormonal homeostatic disorders, infertility, disability, and death. That is why it is so important to study and introduce rehabilitation measures for gynecological cancer patients, by taking into account their age, efficiency of recovery methods, and safety requirements, into the practical activities of oncologists, pediatricians, gynecologists, rehabilitation therapists, and other specialists. The purpose of this review was to analyze the pattern of gynecological cancer and evidence-based current approaches to different types of rehabilitation in children with this condition.

Keywords: 
oncology
gynecology
pediatrics
reproductive function preservation
rehabilitation
quality of life
ovarian tumors
perivascular epitheloid cell tumors (PEComas)



References: 
  1. Kaprin A.D., Starinskij V.V., Petrova G.V. Sostojanie onkologicheskoj pomoschi naseleniju Rossii v 2017 g. / M.: MNIOI im. P.A. Gertsena – filial FGBU «NMIRTs» Minzdrava Rossii, 2018; s. 4–124 [Kaprin A.D., Starinskii V.V., Petrova G.V. Sostoyanie onkologicheskoi pomoshchi naseleniyu Rossii v 2017 g. / M.: MNIOI im. P.A. Gertsena – filial FGBU «NMIRTs» Minzdrava Rossii, 2018; s. 4–124 (in Russ.)].
  2. Zheludkova O.G., Poljakov V.G., Rykov M.Ju. i dr. Klinicheskie projavlenija onkologicheskih zabolevanij u detej. Prakt. rekomendatsii / SPb: Tipografija Mihaila Fursova, 2017; 52 [Zheludkova O.G., Polyakov V.G., Rykov M.Yu. i dr. Klinicheskie proyavleniya onkologicheskikh zabolevanii u detei. Prakt. rekomendatsii / SPb: Tipografiya Mikhaila Fursova, 2017; 52 (in Russ.)].
  3. Men' T.H., Poljakov V.G., Aliev M.D. Epidemiologija zlokachestvennyh novoobrazovanij u detej v Rossii // Onkopediatrija. – 2014; 1 (1): 7–12 [Men T.C., Polyakov V.G., Aliev M.D. Epidemiology of Childhood Cancer in Russia // Oncopediatrics. – 2014; 1(1): 7–12 (in Russ.)].
  4. Rykov M.Ju., Bajbarina E.M., Chumakova O.V. i dr. Epidemiologija zlokachestvennyh novoobrazovanij u detej v Rossijskoj Federatsii: analiz osnovnyh pokazatelej i puti preodolenija defektov statisticheskih dannyh // Onkopediatrija. – 2017; 4 (3): 159–76 [Rykov M.Y., Baibarina E.N., Chumakova O.V., Polyakov V.G. Cancer epidemiology in children in the russian federation: analysis of key indicators and ways to overcome the statistical data defects // Oncopediatrics. – 2017; 4 (3): 159–76 (in Russ.)]. https://doi.org/10.15690/onco.v4i3.1747.
  5. Chundokova M.A., Kokolina V.F., Golodenko N.V. i dr. Diagnostika i lechenie opuholevidnyh obrazovanij jaichnikov u novorozhdennyh // Vopr. sovr. pediat. – 2006; 1 (89): 650 [Chundokova M.A., Kokolina V.F., Golodenko N.V. et al. Diagnostika i lechenie opukholevidnykh obrazovanii yaichnikov u novorozhdennykh // Vopr. sovr. pediat. – 2006; 1 (89): 650 (in Russ.)].
  6. Adamjan L.V., Sibirskaja E.V., Bogdanova E.A. i dr. Dobrokachestvennye opuholi i opuholevidnye obrazovanija jaichnikov u detej i podrostkov (obzor literatury) // Problemy reproduktsii. – 2016; 22 (2): 73–7 [Adamyan L.V., Sibirskaya E.V., Bogdanova E.A. et al. Ovarian benign tumors and tumor-like formations of girls and young women (a review) // Russian Journal of Human Reproduction = Problemy reproduktsii. – 2016; 22 (2): 73–7 (in Russ.)]. https://doi.org/10.17116/repro201622273-77.
  7. Bhattacharyya N., De A., Bera P. et al. Ovarian tumors in pediatric age group – A clinicopathologic study of 10 years’ cases in West Bengal, India // Indian J. Med. Paediatr. Oncol. – 2010; 31 (2): 54–7. DOI: 10.4103/0971-5851.71656.
  8. Nechushkina I.V., Karseladze A.I. Pekoma vlagalischa u devochki (analiticheskij obzor) // Reproduktivnoe zdorov'e detej i podrostkov. – 2016; 6: 20–33 [Nechushkina I.V., Karseladze A.I. PEComa of the vagina in a girl (analytical review) // Reproduktivnoe zdorov’e detei i podrostkov. – 2016; 6: 20–33 (in Russ.)].
  9. Kozhahmetov B.Sh., Abisatov G.H., Zhumadullaev B.M. i dr. Klinicheskie protokoly MZ RK – Opuholi polovyh organov u devochek (Prikazy №883, №165), 2012 [Kozhakhmetov B.Sh., Abisatov G.Kh., Zhumadullaev B.M. et al. Klinicheskie protokoly MZ RK – Opukholi polovykh organov u devochek (Prikazy №883, №165), 2012 (in Russ.)].
  10. Solopova A.G., Makatsarija A.D., Jakovleva O.N. i dr. Sovremennye podhody k diagnostike i lecheniju opuholej zhenskih polovyh organov u detej i podrostkov // Georgian Medical News. – 2017; 11 (272): 25–31 [Solopova A., Makatsaryia A., Yakovleva O. et al. Modern approaches to diagnosis and treatment of tumors of female genitals of children and adolescents (review) // Georgian Medical News. – 2017; 11 (272): 25–31 (in Russ.)].
  11. Lin X., Wu D., Zheng Na. et al. Gonadal germ cell tumors in children: A retrospective review of a 10-year single-center experience // Medicine. – 2017; 96 (26): e7386. DOI: 10.1097/MD.0000000000007386.
  12. Nechushkina I.V. Poroki razvitija i opuholi gonad u detej // Detskaja onkologija. – 2003; 1: 29–33 [Nechushkina I.V. Poroki razvitiya i opukholi gonad u detei // Detskaya onkologiya. – 2003; 1: 29–33 (in Russ.)].
  13. Jatsyk S.P., Glybina T.M., Tin I.F. i dr. Sochetannye poroki razvitija mochepolovoj sistemy u devochek // Reproduktivnoe zdorov'e detej i podrostkov. – 2016; 1 (66): 25–31 [Yatsyk S.P., Glybina T.M., Tin I.F. et al. Combined urogenital malformations in girls // Reproduktivnoe zdorov’e detei i podrostkov. – 2016; 1 (66): 25–31 (in Russ.)].
  14. Shaaban A., Rezvani M., Elsaues K. et al. Ovarian malignant germ cell tumors: cellular classification and clinical and imaging features // Radiographics. – 2014; 34 (3): 777–801. DOI: 10.1148/rg.343130067.
  15. Belpomme D., Irigaray P., Hardell L. et al. The multitude and diversity of environmental carcinogens // Environm. Res. – 2007; 105 (3): 414–29. DOI: 10.1016/j.envres.2007.07.002.
  16. Bunin G. Nongenetic causes of childhood cancers: evidence from international variation, time trends, and risk factor studies // Toxicol. Appl. Pharmacol. – 2004; 199 (2): 91–103. DOI: 10.1016/j.taap.2003.12.028.
  17. Spector L., Pankratz N., Marcotte E. Genetic and nongenetic risk factors for childhood cancer // Pediatr. Clin. – 2015; 62 (1): 11–25. DOI: 10.1016/j.pcl.2014.09.013.
  18. Kurman R., Carcangiu M., Herrington C. et al. WHO Classification of Tumours of the Female Reproductive Organs // Lyon: International Agency for Research on Cancer. – 2014; 4: 6.
  19. Muslimova S.Ju., Uvarova E.V. Sovremennye printsipy diagnostiki i lechenija oslozhnennyh opuholevidnyh obrazovanij i opuholej jaichnikov u devochek // Reproduktivnoe zdorov'e detej i podrostkov. – 2014; 6 (59): 20–8 [Muslimova S.Yu., Uvarova E.V. Modern principles of diagnostics and treatment of tumor formations and ovarian tumors complications in girls // Reproduktivnoe zdorov’e detei i podrostkov. – 2014; 6 (59): 20–8 (in Russ.)].
  20. Tshaj V.B., Andreeva A.A., Blinova E.N. i dr. Klinicheskij sluchaj gigantskoj granulezokletochnoj opuholi jaichnika // Sibirskoe meditsinskoe obozrenie. – 2014; 2: 86–9 [Tskhay V.B., Andreeva A.A., Blinova E.N. et al. Clinical case of a giant ovarian granulosa cell tumor // Sibirskoe meditsinskoe obozrenie. – 2014; 2: 86– (in Russ.)].
  21. Matsko D.E. Sovremennye predstavlenija o morfologicheskoj klassifikatsii sarkom mjagkih tkanej i ih prakticheskoe znachenie // Prakt. onkol. – 2013; 14 (2): 77–86 [Matsko D.E. Sovremennye predstavleniya o morfologicheskoi klassifikatsii sarkom myagkikh tkanei i ikh prakticheskoe znachenie // Prakt. onkol. – 2013; 14 (2): 77–86 (in Russ.)].
  22. Conlon N., Soslow R., Murali R. Perivascular epithelioid tumours (PEComas) of the gynaecological tract // J. Clin. Pathol. – 2015; 68 (6): 418–26. DOI: 10.1136/jclinpath-2015-202945.
  23. Nechushkina I.V. Pekomy // Onkopediatrija. – 2016; 3 (4): 267–76 [Nechushkina I.V. PEComa // Oncopediatrics. – 2016; 3 (4): 267–76 (in Russ.)]. https://doi.org/10.15690/onco.v3i4.1630.
  24. Turgal M., Ozyuncu O., Yazicioglu A. Outcome of sonographically suspected fetal ovarian cysts // Journal of Maternal-Fetal & Neonatal Medicine. – 2013; 26 (17): 1728–32. DOI: 10.3109/14767058.2013.799652.
  25. Chinchure D., Loh A., Ong C. et al. Neonatal ovarian cysts: role of sonography in diagnosing torsion // Ann. Acad. Medicine-Singapore. – 2011; 40 (6): 291–5.
  26. Silina I.A. Opuholevye markery pri rake shejki matki // Remedium Privolzh'e. – 2016; 8 (148): 20–1 [Silina I.A. Opukholevye markery pri rake sheiki matki // Remedium Privolzh’e. – 2016; 8 (148): 20–1 (in Russ.)].
  27. Li M., Li B.-Y., Jiang L.-L. Expression of microRNA-142-3p in cervical cancer and its correlation with prognosis // Eur. Rev. Med. Pharmacol. Sci. – 2017; 21: 2346–50.
  28. Ju Li., Yu Y.-X., Sun C.-Y. et al. Surgical high ligation of the ovarian vein and preservation of ovarian function for twisted ovarian tumors // Chinese Med. J. – 2012; 125 (20): 3744–6. DOI: 10.3760/cma.j.issn.0366-6999.2012.20.027.
  29. Spinelli C., Strambi S., Pucci V. et al. Treatment of ovarian lesions in children and adolescents: a retrospective study of 130 cases // Pediatr. Hematol. Oncol. – 2015; 32 (3): 199–206. DOI: 10.3109/08880018.2013.856050.
  30. Terenziani M., Inserra A., D’Angelo P. et al. Mature and immature teratoma: a report from the second Italian pediatric study // Pediatric blood & cancer. – 2015; 62 (7): 1202–8. DOI: 10.1002/pbc.25423.
  31. Medscape.com. Cancer and rehabilitation. Available at https://emedicine.medscape.com/article/320261-overview [Accessed 23 April, 2019].
  32. Solopova A.G., Tabakman Ju.Ju., Idrisova L.E. i dr. Reabilitatsija onkoginekologicheskih bol'nyh. Vzgljad na problemu // Akusherstvo, ginekologija i reproduktsija. – 2015; 9 (4): 46–54 [Solopova A.G., Tabakman Yu.Yu., Idrisova L.E. et al. Rehabilitation of onsogynesologic patients. View of a problem // Akusherstvo, ginekologiya i reproduktsiya = Obstetrics, gynecology and reproduction. – 2015; 4: 46–54 (in Russ.)]. DOI: 10.17749/2070-4968.2015.9.4.046-054.
  33. Maehr B., Wiltschke C., Keilani M. et al. Cancer rehabilitation in Austria – aspects of physical medicine and rehabilitation // Wiener Medizinische Wochenschrift. – 2016; 166 (1–2): 39–43. DOI: 10.1007/s10354-015-0414-1.
  34. Zhang X., Schmitz K., McClean D. et al. Exercise among women with ovarian cancer: A feasibility and pre-/post-test exploratory pilot study // Oncol. Nurs. forum. – 2017; 44 (3): 366–74. DOI: 10.1188/17.ONF.366-374.
  35. Fomina M.P., Divakova T.S. Korrektsija endokrinnoj sistemy v rannem reproduktivnom vozraste pri maloinvazivnyh vmeshatel'stvah po povodu ob'emnyh obrazovanij jaichnikov // Vestnik Vitebskogo gosudarstvennogo meditsinskogo universiteta. – 2003; 2 (4): 37–43 [Fomina M.P., Divakova T.S. Korrektsiya endokrinnoi sistemy v rannem reproduktivnom vozraste pri maloinvazivnykh vmeshatel’stvakh po povodu ob»emnykh obrazovanii yaichnikov // Vestnik Vitebskogo gosudarstvennogo meditsinskogo universiteta. – 2003; 2 (4): 37–43 (in Russ.)].
  36. Barjaeva O.E., Florensov V.V. Polovoe vospitanie devushek-podrostkov v sovremennyh uslovijah: mediko-sotsial'nye aspekty // Vestnik Burjatskogo gosudarstvennogo universiteta. Meditsina i farmatsija. – 2015; 12: 189–93 [Baryaeva O.E., Florensov V.V. Gender education of adolescent giri s in modern conditions: medical and social aspects // Vestnik Buryatskogo gosudarstvennogo universiteta. Meditsina i farmatsiya. – 2015; 12: 189–93 (in Russ.)].
  37. Bober S., Recklitis C., Michaud A. et al. Improvement in sexual function after ovarian cancer: effects of sexual therapy and rehabilitation after treatment for ovarian cancer // Cancer. – 2018; 124 (1): 176–82. DOI: 10.1002/cncr.30976.
  38. Gens G.P., Sirota N.A., Olejnikova I.N. i dr. Distress u bol'nyh rakom jaichnikov // Doktor.Ru. – 2018; 2 (146): 59–62 [Guens G.P., Sirota N.A., Oleinikova I.N. et al. Distress in Ovarian Cancer Patients // Doktor.Ru. – 2018; 2 (146): 59–62 (in Russ.)].
  39. Solopova A.G., Vlasina A.Ju., Makatsarija A.D. i dr. Pogranichnye opuholi jaichnikov: aktual'nost' voprosa i problemy reabilitatsii // Georgian Medical News. – 2018; 11 (284): 7–13 [Solopova A., Vlasina A., Makatsariya A. et al. Borderline ovarian tumors: current issues and rehabilitation problems // Georgian Medical News. – 2018; 11 (284): 7–13 (in Russ.)].