HYALURONIC ACID FOR INTRA-ARTICULAR INJECTION: EFFICACY AND SAFETY

DOI: https://doi.org/10.29296/25877305-2019-03-17
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Issue: 
3
Year: 
2019

V. Privolnev(1), Candidate of Medical Sciences, O. Agafonov(2), Candidate of Medical Sciences; A. Rodin(3), Candidate of Medical Sciences; R. Fedorov(4), Candidate of Medical Sciences; A. Shilina(3) 1-Medical Department, AO “R-Pharm”, Smolensk 2-Naval Clinical Hospital No. 1409. Ministry of Defense of Russia, Chernyakhovsk 3-Smolensk State Medical University 4-Federal Center for Traumatology, Orthopedics and Endoprosthesis, Ministry of Health of Russia, Smolensk

Hyaluronic acid (HA) preparations have been known for a rather long time. More than 20 years ago, the Food and Drug Administration (FDA) in the USA permitted their clinical use. Vast experience reflected in numerous high-level studies and meta-analyses has been accumulated during this time. The paper presents data on the pathogenetic substantiation of the clinical use of HA preparations, their results, including those in comparison with other drugs for the therapy of osteoarthrosis (OA). Indications for their use, efficacy, and safety during intra-articular injection are separately considered. The role of HA preparations in the treatment of OA is defined on the basis on the above data.
Keywords: 
rheumatology
osteoarthrosis
gonarthrosis
hyaluronic acid

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