A RARE CLINICAL CASE OF PAGET’S DISEASE OF THE BONE: THE PITFALLS OF DIAGNOSIS AND TREATMENT

DOI: https://doi.org/10.29296/25877305-2019-03-12
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Issue: 
3
Year: 
2019

L. Boeva(1, 2), Candidate of Medical Sciences; E. Kapustina(1, 2), Candidate of Medical Sciences; S. Dogadin(1), MD; E. Klyuchnikova(2), Candidate of Medical Sciences; T. Potupchik(1), Candidate of Medical Sciences; M. Prikhodko(1); T. Pasechnik(2); I. Shilova(2) 1-Prof. V.F. Voino-Yasenetsky Krasnoyarsk State Medical University; 2-Territorial Clinical Hospital, Krasnoyarsk

The paper considers the epidemiology, pathogenesis, clinical presentations, and diagnoses of Paget’s disease of the bone. It describes a case of late diagnosis of the disease and the characteristics of its therapy using zolendronic acid in a young woman.

Keywords: 
Paget’s disease of the bone
osteoblasts
osteoclasts
saber-varus deformity
video-assisted biopsy
zolendronic acid



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References: 
  1. Bashkova I.B., Nikolaev N.S., Bezljudnaja N.V. i dr. Diagnosticheskie aspekty kostnoj bolezni Pedzheta v klinicheskoj praktike // Nauchno-prakt. revmatol. – 2017; 55 (6): 690–7 [Bashkova I.B., Nikolaev N.S., Bezlyudnaya N.V. et al. Diagnostic aspects of Paget’s disease of bone in clinical practice // Rheumatology Science and Practice. – 2017; 55 (6): 690–7 (in Russ.)] https://doi.org/10.14412/1995-4484-2017-690-697.
  2. Korsakova Ju.L. Bolezn' Pedzheta: sovremennye metody lechenija // Sovrem. revmatol. – 2010; 4 (2): 11–7 [Korsakova Y.L. Paget’s disease: current treatment modalities // Modern Rheumatology Journal. – 2010; 4 (2): 11–7 (In Russ.)] https://doi.org/10.14412/1996-7012-2010-596.
  3. Rozhinskaja L.Ja. Bolezn' Pedzheta // Osteoporoz i osteopatii. – 2007; 2: 29–31 [Rozhinskaya L.Ya. Paget’s Disease // Osteoporoz i Osteopatii. – 2007; 2: 29–31 (in Russ.)].
  4. Pigarova E.A. Bolezn' Pedzheta: predstavlenie klinicheskih rekomendatsij endo i aktualizatsija ih v Rossii // Osteoporoz i osteopatii. – 2016; 1: 17–8 [Pigarova E.A. Paget’’s disease of bone: clinical presentation of endo recommendations and updating them in Russia // Osteoporoz i Osteopatii. – 2016; 1: 17–8 (in Russ.)].
  5. Martini G., Gennari L., Merlotti D. et al. Serum OPG and RANKL levels before and after intravenous bisphosphonate treatment in Paget’s disease of bone // Bone. – 2007; 40 (2): 457–63.
  6. Nebot Valenzuela E., Pietschmann P. Epidemiology and pathology of Paget’s disease of bone – a review // Wien Med. Wochenschr. – 2017; 67 (1–2): 2–8.
  7. Ralston S., Layfield R. Pathogenesis of Paget Disease of Bone // Calcif. Tissue Int. – 2012; 91 (2): 97–113.
  8. Sabharwal R., Gupta S., Sepolia S. et al. An Insight in to Paget’s Disease of Bone // Nigerian J. Surg. – 2014; 20 (1): 9–15.
  9. Singer F., Bone H., Hosking D. et al. Paget’s Disease of Bone: An Endocrine Society Clinical Practice Guideline // J. Clin. Endocrinol. Metabol. – 2014; 99 (12): 4408–22.
  10. Shaker J. Paget’s Disease of Bone: A Review of Epidemiology, Pathophysiology and Management // Therapeutic Advances in Musculoskeletal Disease. – 2009; 1 (2): 107–25.
  11. Tan A., Ralston S. Paget’s disease of bone // QJM Int. J. Med. – 2014; 107: 865–9.