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DOI: https://doi.org/10.29296/25877305-2019-01-15

V. Shalygin; E. Ilyina; I. Sinitsina, MD; M. Savelyeva, MD; Professor D. Sychev, MD, Corresponding Member of the Russian Academy of Sciences Russian Medical Academy of Continuing Professional Education, Ministry of Health of Russia, Moscow

The given clinical case of a 78-year-old female patient who has fallen and has several contributory factors to falls demonstrates the possibility of predicting these falls, as shown by a pharmacological audit.

elderly patients
drugs that can increase risk of falls
angiotensin-converting enzyme inhibitors
clinical and pharmacological audit
Bierce criteria
STOPP criteria
anticholinergic cognitive burden scale
online drug interaction checker Drugs.com

  1. Lee J., Choi M., Kim C. Falls, a Fear of Falling, and related Factors in Older Adults with Complex Chronic Disease // J. Clin. Nurs. – 2017; 26: 23–24.
  2. Informacionnyy byulleten` VOZ. Padeniya. Yanvar` 2018 [WHO. Falls. January 2018 (in Russ.)]. http://www.who.int/ru/news-room/fact-sheets/detail/falls
  3. Ambrose A., Paul G., Hausdorff J. Risk factors for falls among older adults: a review of the literature // Maturitas. – 2013; 75 (1): 51–61.
  4. Zelmer H. Medications and Falls in Older People // J. Pharm. – 2011; 3; 1: 1593–602.
  5. Ming Y., Zecevic A. Medications & Polypharmacy Influence on Recurrent Fallers in Community: a Systematic Review // Canadian Geriatr. J. – 2018; 21 (1): 14–25.
  6. NHS, Drugs and falls, Guidance Sheet 5. Caring for Care Homes – 2015. https://www.gov.im/media/1347552/care-homes-medication-and-falls-december-2014.pdf
  7. Gnjidic D. et al. Polypharmacy cutoff and outcomes: five or more medicines were used to identify community-dwelling older men at risk of different adverse outcomes // J. Clin. Epidemiol. – 2012; 65 (9): 989–95.
  8. Kazakov A.S., Lepahin V.K., Astahova A.V. Oslozhneniya farmakoterapii, svyazannye s vzaimodeystviem lekarstvennyh sredstv // Ros. mediko-biol. vestn. – 2013; 3: 70–6 [Kazakov A.S., Lepakhin V.K., Astakhova A.V. Drug-drug interactions iike a reason of adverse drug reactions // Ros. mediko-biol. vestn. – 2013; 3: 70–6 (in Russ.)].
  9. Hansen P., Horn J. Proposal for a new tool to evaluate drug interaction cases // Ann. Pharmacother. – 2007; 41 (4): 674–80.
  10. Carnahan R. et al. The anticholinergic drug scale as a measure of drug related anticholinergic burden: Association with serum anticholinergic activity // J. Clin. Pharmacol. – 2006; 46 (12): 1481–6.
  11. Han L. et al. Use of medications with anticholinergic effect predicts clinical severity of delirium symptoms in older medical inpatients // Arch. Intern. Med. – 2011; 161: 1099–105.
  12. Updated Beers Criteria for Potentially Inappropriate Medication Use in Older Adults. // Am. Geriatr. Soc. – 2015; 63 (11): 2227–46 DOI: 10.1111/jgs.13702.
  13. Gallagher R., Ryan S., Byrne S. et al. STOPP (Screening Tool of Older Person’s Prescriptions) and START (Screening Tool to Alert doctors to Right Treatment). Consensus validation // Clin. Pharmacol. Ther. – 2008; 46 (2): 72–83.
  14. Darowski A. et al. Medicines and Falls in Hospital: Guidance Sheet // National Institute for Health and Clinical Excellence guidelines, 2011; https://www.rcplondon.ac.uk/file/933/download?token=drzlaAJ2
  15. Sychev D.A., Zhuchkov A.V., Bogova O.T. i dr. Padeniya pacientov pozhilogo i starcheskogo vozrasta: vklad lekarstvennyh sredstv // Klin. gerontol. – 2017; 23: 56–64 [Sychev D.A., Zhuchkov A.V., Bogova O.T. et al. Padenija pacientov pozhilogo i starcheskogo vozrasta: vklad lekarstvennyh sredstv // Klinicheskaja gerontologija. – 2017; 23: 56–64 (in Russ.)].
  16. Drug Interactions Checker. https://www.drugs.com/drug_interactions.php
  17. Sychev D.A., Danilina K.S. Otdelenov V.A. Kliniko-farmakologicheskie podhody k resheniyu problemy polipragmazii u pozhilyh pacientov v usloviyah mnogoprofil`nogo stacionara // Klin. farmakol. i ter. – 2013; 22 (2): 87–92 [Sychev D.A., Danilina K.S., Otdelenov V.A. Clinico-pharmacological approaches to the solution of the polypragmasy problem in elderly patients in the multi-speciality hospital settings // Clin. Pharmacol. Ther. – 2013; 22 (2): 87–92 (in Russ.)].
  18. Kostyleva M.N., Belousov Yu.B., Gracianskaya A.N. i dr. Ocenka bezopasnosti lekarstvennoy terapii v klinicheskoy praktike» // Farmakoe`konomika. Sovrem. farmakoe`konom. i farmakoe`pidemiol. – 2014; 7 (1): 26–31 [Kostyleva M.N., Belousov Y.B., Gratsianskaya A.N., Postnikov S.S. Evaluation of safety of drug therapy in clinical practice. Pharmacoeconomics // Modern pharmacoeconomics and pharmacoepidemiology. – 2014; 7 (1): 27–32 (in Russ.)].