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GDF15 PROTEIN AND CARDIAC HEMODYNAMIC FUNCTIONS IN WOMEN WITH HYPERTENSIVE DISEASE

DOI: https://doi.org/10.29296/25877305-2019-01-01
Issue: 
1
Year: 
2019

Professor B. Kuznik(1, 2), MD; Professor S. Davydov(1, 2), MD; Professor E. Roitman(3), Biol.D3; Yu. Smolyakov(2), Candidate of Medical Sciences; E. Guseva(2), Candidate of Medical Sciences; A. Stepanov(2), MD; Professor N. Tsybikov(1), MD; E. Fefelova(1), Candidate of Medical Sciences; N. Linkova(4, 5), Biol.D; Professor V. Khavinson(4, 6), Corresponding Member of the Russian Academy of Sciences 1-Chita State Medical Academy 2-Innovation Clinic, Academy of Health, Chita 3-N.I. Pirogov Russian National Research Medical University, Moscow 4-Saint Petersburg Institute of Bioregulation and Gerontology 5-Peter the Great Saint Petersburg Polytechnic University 6-I.P. Pavlov Institute of Physiology, Russian Academy of Sciences, Saint Petersburg

The authors investigated the relationship of cytokine GDF15 concentrations to the hemostatic system status, lipid metabolism, and cardiovascular system functions in hypertensive disease (HD) during its drug therapy alone (Group 1) and in combination with kinesitherapeutic procedures (Group 2). It was shown that GDF15 levels were 1.4 times lower in Group 1 than in Group 2 and that there were lipid metabolic changes, hypercoagulation, cardiodynamic dysfunctions, and a balance between hemodynamic and oscillatory indices, while all the studied parameters were near-normal in Group 2. It was found that kinesitherapy may be an additional effective treatment for HD.

Keywords: 
cardiology
hypertensive disease
kinesitherapy
GDF15
lipid spectrum
thrombodynamic indicators
cardiodynamic and hemodynamic functions



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