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BIOREGULATORY APPROACH TO COMBINATION THERAPY FOR PATIENTS WITH GASTROESOPHAGEAL REFLUX DISEASE

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Issue: 
12
Year: 
2016

N. Komleva (1), MD; Professor A. Maryanovsky (2), MD; Associate Professor A. Danilov (1), Candidate of Medical Sciences; I. Zaikina (1), Candidate of Medical Sciences 1 -Saratov Research Institute for Agricultural Hygiene, Russian Federal Service for Supervision of Consumer Rights Protection and Human Welfare 2 -N.I. Pirogov Russian National Research Medical University, Moscow

The paper gives the results of an open-label longitudinal randomized study, which suggest that is expedient to incorporate the antihomotoxic agents Spascupreel and Mucosa compositum into combination therapy for patients with gastroesophageal reflux disease; the drugs regress the symptoms of the disease, increase the period of remission, and improve the results of endoscopic studies and the indicators of quality of life.

Keywords: 
gastroenterology
gastroesophageal reflux disease
antihomotoxic agents
bioregulation
bioregulatory drugs
Spascupreel and Mucosa compositum



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References: 
  1. Bashashati M., Hejazi R., Andrews C. et al. Gastroesophageal reflux symptoms not responding to proton pump inhibitor: GERD, NERD, NARD, esophageal hypersensitivity or dyspepsia? // Can. J. Gastroenterol. Hepatol. – 2014; 28 (6): 335–41.
  2. Bruley des Varannes S., Cestari R., Usova L. et al. Classification of adults suffering from typical gastroesophageal reflux disease symptoms: contribution of latent class analysis in a European observational study // BMC Gastroenterol. – 2014; 14: 112.
  3. El-Serag H., Sweet S., Winchester C. et al. Update on the epidemiology of gastro-oesophageal reflux disease: a systematic review // Gut. – 2014; 63 (6): 871–80.
  4. Mason J., Hungin A. Review article: gastro-oesophageal reflux disease – the health economic implications // Aliment. Pharmacol. Ther. – 2005; 22 (1): 20–31.
  5. Tack J., Becher A., Mulligan C. Systematic review: the burden of disruptive gastro-oesophageal reflux disease on health-related quality of life // Aliment. Pharmacol. Ther. – 2012; 35 (11): 1257–66.
  6. Nwokediuko S. Current trends in the management of gastroesophageal reflux disease: a review // ISRN Gastroenterol. – 2012; ID391631.
  7. Boeckxstaens G., El-Serag H., Smout A. et al. Symptomatic reflux disease: the present, the past and the future // Gut. – 2014; 63 (7): 1185–93.
  8. Subramanian C., Triadafilopoulos G. Refractory gastroesophageal reflux disease // Gastroenterol. Rep. – 2015; 3 (1): 41–53.
  9. Bueno L., Lafforgue G., Beaufrand C. et al. Colonic and anorectal disorders targeting the IBS pathophysiology in stressed rats using a multicomponent HE-400 // J. Gastroenterol. Hepatol. – 2013; 28 (suppl. 3): 347–8.
  10. Komleva N.E., Spirin V.F., Zaikina I.V. Izuchenie effektivnosti antigomotoksicheskoj terapii GERB // Mezhdunarodnyj zhurnal prikladnyh i fundamental'nyh issledovanij. – 2015; 8–1: 52–4.
  11. Lundell L., Dent J., Bennett J. et al. Endoscopic assessment of oesophagitis: clinical and functional correlates and further validation of the Los Angelesclassification // Gut. – 1999; 45 (2): 172–80.
  12. Ware J. SF-36 Health Survey Update // Spine. – 2000; 25: 3130–9.
  13. Novik A.A., Ionova T.I. Rukovodstvo po issledovaniju kachestva zhizni v meditsine / SPb: Neva, 2002; 320.