ASSOCIATION BETWEEN POLYMORPHISM OF THE CYP2D6 GENE AND EFFICACY AND SAFETY PROFILE OF HALOPERIDOL IN PATIENTS WITH ALCOHOL ADDICTION

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Issue: 
3
Year: 
2016

M. Zastrozhin (1,2); K. Ryzhikovа (1); O. Avdeeva (1); J. Sozaeva (1); E. Grishina (1), Candidate of Medical Sciences; Professor D. Sychev (1), MD; Professor E. Brune (2), MD; L. Savchenko (1), Candidate of Medical Sciences; N. Sannikova (3) 1 -Russian Medical Academy of Postgraduate Education Moscow 2 -Peoples’ Friendship University of Russia, Moscow 3 -Moscow Research and Practical Centre for Narcology

The study involved 20 men with alcohol addiction. The efficacy and safety of haloperidol was evaluated by international psychometric scales. The genotype of CYP2D6 was investigated by real-time PCR. The study revealed a statistically significant patterns between the polymorphism of CYP2D6 and the efficacy and safety of haloperidol.

Keywords: 
psychiatry–narcology
haloperidol
polymorphism
CYP2D6
side effects
alcoholism



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References: 
  1. Sivolap Ju.P. Ratsional'nye podhody k primeneniju nejroleptikov v narkologicheskoj praktike // Zdorovaja Ukraina. – 2008; 7 (1): 83–4.
  2. Butwicka A1., Krystyna S., Retka W. et al. Neuroleptic malignant syndrome in an adolescent with CYP2D6 deficiency // Eur. J. Pediatr. – 2014; 173 (12): 1639–42.
  3. Gasso P., Papagianni K., Bobadilla R. et al. Relationship between CYP2D6 genotype and haloperidol pharmacokinetics and extrapyramidal symptoms in healthy volunteers // Pharmacogenomics. – 2013; 14 (13): 1551–63.
  4. Van der Weide K1., van der Weide J. The Influence of the CYP3A4*22 Polymorphism and CYP2D6 Polymorphisms on Serum Concentrations of Aripiprazole, Haloperidol, pimozide, and risperidone in psychiatric patients // J. Clin. Psychopharmacol. – 2015; 35 (3): 228–36.
  5. Nakamura A1., Mihara K., Nemoto K. et al. Lack of correlation between the steady-state plasma concentrations of aripiprazole and haloperidol in Japanese patients with schizophrenia // Ther. Drug. Monit. – 2014; 36 (6): 815–8.
  6. Jiang X., Shen H., Yu A. Pinolinemay be used as a probe for CYP2D6 activity // Drug Metab. Dispos. – 2009; 37 (3): 443–6.
  7. Langaee T., Hamadeh I., Chapman A. et al. A Novel Simple Method for Determining CYP2D6 Gene Copy Number and Identifying Allele(s) with Duplication/ Multiplication // PLoS One. – 2015; 10 (1): e0113808.
  8. Crews K., Gaedigk A., Dunnenberger H. et al. Clinical Pharmacogenetics Implementation Consortium (CPIC) guidelines for codeine therapy in the context of cytochrome P450 2D6 (CYP2D6) genotype // Clin. Pharmacol. Ther. – 2012; 91 (2): 321–6.
  9. Kukes V.G., Grachev S.V., Sychev D.A. i dr. Metabolizm lekarstvennyh sredstv: nauchnye osnovy personalizirovannoj meditsiny / M.: GEOTAR- Media, 2008.
  10. Zanger U., Raimundo S., Eichelbaum M. Cytochrome P450 2D6: overview and update on pharmacology, genetics, biochemistry // Naunyn Schmiedebergs Arch. Pharmacol. – 2004; 369 (1): 23–37.