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ASSOCIATION BETWEEN POLYMORPHISM OF THE CYP2D6 GENE AND EFFICACY AND SAFETY PROFILE OF HALOPERIDOL IN PATIENTS WITH ALCOHOL ADDICTION

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Issue: 
3
Year: 
2016

M. Zastrozhin (1,2); K. Ryzhikovа (1); O. Avdeeva (1); J. Sozaeva (1); E. Grishina (1), Candidate of Medical Sciences; Professor D. Sychev (1), MD; Professor E. Brune (2), MD; L. Savchenko (1), Candidate of Medical Sciences; N. Sannikova (3) 1 -Russian Medical Academy of Postgraduate Education Moscow 2 -Peoples’ Friendship University of Russia, Moscow 3 -Moscow Research and Practical Centre for Narcology

The study involved 20 men with alcohol addiction. The efficacy and safety of haloperidol was evaluated by international psychometric scales. The genotype of CYP2D6 was investigated by real-time PCR. The study revealed a statistically significant patterns between the polymorphism of CYP2D6 and the efficacy and safety of haloperidol.

Keywords: 
psychiatry–narcology
haloperidol
polymorphism
CYP2D6
side effects
alcoholism



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