The frequency of MTHFR C677T polymorphism in chronic kidney disease

DOI: https://doi.org/10.29296/25877305-2019-05-03
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Issue: 
5
Year: 
2019

O. Sibireva(1, 2), MD; Professor E. Kalyuzhina(1), MD; Professor V. Kalyuzhin(1), MD 1-Siberian State Medical University, Tomsk 2-Regional Clinical Hospital, Tomsk

The role of methylenetetrahydrofolate reductase (MTHFR) gene mutation in the progression of chronic glomerulonephritis was investigated. MTHFR C677T polymorphism was evaluated by polymerase chain reaction-restriction analysis of the amplified DNA fragments. The paper shows the prevalence of polymorphic variants in healthy individuals and patients with kidney diseases: 90 with different forms of chronic glomerulonephritis and 30 with chronic renal failure (CRF). MTHFR C677T polymorphism was found in 53% of patients with CRF (odds ratio (OR) = 1.66; p < 0.005) and in 31% of healthy individuals. There is a relationship between the MTHFR C677T polymorphism and the development of CRF.
Keywords: 
nephrology
methylenetetrahydrofalate reductase
MTHFR C677T polymorphism
chronic glomerulonephritis
chronic renal failure

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