MONITORING OF BK VIRUS IN RECIPIENTS WITHIN ONE YEAR AFTER ALLOGENEIC KIDNEY TRANSPLANTATION

DOI: https://doi.org/10.29296/25877305-2018-05-20
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Issue: 
5
Year: 
2018

A. Matveev(1); Professor A. Ragimov(1), MD; Professor M. Kaabak(2), MD; Professor N. Dashkova(1), MD; E. Salimov(1), MD; N. Babenko(2), Candidate of Medical Sciences; MD; N. Matveeva(2) 1-Laboratory Blood Transfusiological Complex, I.M. Sechenov First Moscow State Medical University (Sechenov University) 2-B.V. Petrovsky Russian Research Center of Surgery, Moscow

Eighty-two patients were examined within 12 months after transplantation to determine the presence of BK virus (BKV) in the blood and urine of allogeneic kidney transplant recipients. Plasma and urine BKV DNA levels were quantified. A higher risk for BK nephropathy was established in patients with a high level of BK viruria and viremia for a long time.
Keywords: 
transplantation
BK virus
BK virus nephropathy
kidney transplantation

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References: 
  1. Hirsh H., Drachenberg C., Steiger J. et al. Polyomavirus associated nephropathy in renal transplantation // Adv. Exp. Med. Biol. – 2006; 577: 160–73.
  2. Mihatsch M. Polyomavirus nephropathy: a brief review with special emphasis on clinico-patholgical aspects // Prilozi. – 2012; 33: 5–22.
  3. Gardner S., Field A., Coleman D. et al. New human papovavirus (B.K.) isolated from urine after renal transplantation // Lancet. – 1971; 1: 1253–7.
  4. Randhawa P., Finkelstein S., Scantlebury V. et al. Human polyoma virus-associated interstitial nephritis in the allograft kidney // Transplantation. – 1999; 67: 103–9.
  5. Egli A., Infanti L., Stebler C. et al. Polyomavirus BKV and JCV replication in plasma and urine in healthy blood donors // Am. J. Transpl. – 2008; 8 (Suppl. 2): 460.
  6. Zhong S., Zheng H., Suzuki M. et al. Age-related urinary excretion of BK polyomavirus by non-immunocompromised individuals // J. Clin. Microbiol. – 2007; 45: 193.
  7. Kalvatchev Z., Slavov S., Shtereva M. et al. Reactivation of Polyomavirus hominis 1 (BKV) during pregnancy and the risk of mother-to-child transmission // J. Clin. Virol. – 2008; 43 (3): 328–9.
  8. Hirsch H., Randhawa P. AST infectious diseases community of practice. BK polyomavirus in solid organ transplant recipients // Am. J. Transpl. – 2013; 13: 179–88.
  9. Momynaliev K., Gribanov O., Shevtsov A. et al. Prevalence and subtypes of BK virus in pediatric renal transplant recipients in Russia // Pediatr. Transpl. – 2012; 16 (2): 151–9.
  10. Costa C., Cavallo R. Polyomavirus-associated nephropathy // World J. Transpl. – 2012; 2 (6): 84–94.
  11. Borni-Duval C., Caillard S., Olagne J. et al. Risk factors for BK virus infection in the era of therapeutic drug monitoring // Transplantation. – 2013; 95: 1498–505.
  12. Dharnidharka V., Cherikh W., Abbott K. An OPTN analysis of national registry data on treatment of BK virus allograft nephropathy in the United States // Transplantation. – 2009; 87: 1019–26.
  13. Drachenberg C., Papadimitriou J., Wali R. et al. Improved outcome of polyoma virus allograft nephropathy with early biopsy // Transpl. Proc. – 2004; 36: 758–9.
  14. Nickeleit V., Mihatsch M. Polyomavirus nephropathy in native kidneys and renal allografts: an update on an escalating threat // Transpl. Int. – 2006; 19 (12): 960–73.
  15. Drachenberg C., Papadimitriou J., Hirsch H. et al. Histological patterns of polyomavirus nephropathy: correlation with graft outcome and viral load // Am. J. Transpl. – 2004; 4 (12): 2082–92.
  16. Hirsch H., Steiger J. Polyomavirus BK // Lancet. Infect. Dis. – 2003; 3: 611–23.
  17. Brennan D., Agha I., Bohl D. et al. Incidence of BK with tacrolimus versus cyclosporine and impact of preemptive immunosuppression reduction // Am. J. Transplant. – 2005; 5: 582–94.
  18. Bressollette-Bodin C., Coste-Burel M., Hourmant M. et al. A prospective longitudinal study of BKvirus infection in 104 renal transplant recipients // Am. J. Transplant. – 2005; 5: 1926–33.
  19. Hirsch H., Knowles W., Dickenmann M. et al. Prospective study of polyomavirus type BK replication and nephropathy in renal transplant recipients // N. Engl. J. Med. – 2002; 347: 488–96.
  20. Wiseman A. Polyomavirus Nephropathy: A current perspective and clinical considerations // Am. J. Kidney Dis. – 2009; 54 (1): 131–42.