Подагра: новые терапевтические стратегии
DOI: https://doi.org/10.29296/25877305-2021-06-04
Номер журнала:
6
Год издания:
2021
В настоящее время известно, что длительное отложение уратов требует лечения не только во время
острых эпизодов, но и направленного на модуляции активности ключевых ферментов, участвующих метаболизме и
экскреции уратов, включая ксантиноксидоредуктазу (КОР) и УРАТ1. В обзоре представлены последние данные об
эффективности ингибиторов КОР и урикозурических соединений в снижении уровня мочевой кислоты (МК) как в
общем кровотоке, так и в периферических тканях. Основное внимание уделяется влиянию новых ингибиторов КОР на
метаболизм МК. Снижение уровня МК через ингибирование КОР связано с ослаблением окислительного стресса,
который приводит к эндотелиальной дисфункции, тем самым способствуя развитию сахарного диабета, артериальной
гипертензии, атеросклероза и хронической сердечной недостаточности. Таким образом, предотвращение накопления
кислородных радикалов, генерируемых КOР, становятся новым направлением в лечении как гиперурикемии, так и
подагры.
Ключевые слова:
подагра
гиперурикемия
окислительный стресс
ингибиторы ксантиноксидоредуктазы
анакинра
канакинумаб
фебуксостат
лезинурад
риноласепт
левотофизопам
пеглотиказа
Для цитирования
Н.А. Куницкая Подагра: новые терапевтические стратегии
. Врач, 2021; (6): 16-21 https://doi.org/10.29296/25877305-2021-06-04Список литературы:
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