ПРОБИОТИКИ В ХИРУРГИИ

Скачать статью в PDF
Номер журнала: 
4
Год издания: 
2016

В. Привольнев (1), кандидат медицинских наук, Е. Ушкалова (2), доктор медицинских наук, профессор 1 -Смоленский государственный медицинский университет 2 -Российский университет дружбы народов, Москва E-mail: vladislav.privolnev@gmail.com

Представлены данные о потенциальной выгоде для пациента и хирурга от внедрения в клиническую практику пробиотиков при хирургических заболеваниях. Многочисленные исследования продемонстрировали снижение риска инфицирования области хирургического вмешательства, несостоятельности анастомозов, легочных и урологических осложнений при их назначении. Сделана попытка обобщить существующие сведения об этом и дать конкретные рекомендации по выбору пробиотиков, дозировке, кратности и длительности их использования у хирургических пациентов.

Ключевые слова: 
фармакология
пробиотики
послеоперационные осложнения
подготовка кишечника
инфекции области хирургического вмешательства
несостоятельность анастомоза

Для цитирования
Привольнев В., Ушкалова Е. ПРОБИОТИКИ В ХИРУРГИИ . Врач, 2016; (4): 27-32


It appears your Web browser is not configured to display PDF files. Download adobe Acrobat или click here to download the PDF file.

Список литературы: 
  1. Martin G., Mannino D., Eaton S. The epidemiology of sepsis in the United 1. States from 1979 through 2000 // N. Engl. J. Med. – 2003; 348: 1546–54.
  2. Barie P., Williams M., McCollam J. The PROWESS Surgical Evaluation 2. Committee: benefit/risk profile of drotrecogin alfa (activated) in surgical patients with severe sepsis // Am. J. Surg. – 2004; 188: 212–20.
  3. Sawyer R., Raymond D., Pelletier S. et al. Implications of 2,457 3. consecutive surgical infections entering year 2000 // Ann. Surg. – 2001; 233: 867–74.
  4. Wilson S., Faulkner K. Impact of anatomical site on bacteriological and 4. clinical outcome in the management of intraabdominal infections // Am. Surg. – 1998; 64: 402–7.
  5. Bäckhed F., Ley R., Sonnenburg J. Host–bacterial mutualism in the human intestine // Science. – 2005; 307: 1915–9.Guarner F., Malagelada J. Gut flora in health and disease // Lancet. – 2003; 6. 361: 512–9.
  6. MacFie J., Reddy B., Gatt M. Bacterial translocation studied in 927 patients 7. over 13 years // Br. J. Surg. – 2006; 93 (1): 87–93.
  7. Naaber P., Smidt I., Tamme K. Translocation of indigenous microflora in an 8. experimental model of sepsis // J. Med. Microbiol. – 2000; 49: 431–9.
  8. Lin H., Su B., Chen A. et al. Oral probiotics reduce the incidence and 9. severity of necrotizing enterocolitis in very low birth weight infants. Outcome and cost of intensive care for very low birth weight infants // Pediatrics. – 2005; 115 (1): 1–4.
  9. D’Souza A., Raj Cumar C., Cooke J. et al. Probiotics in prevention of 10. antibiotic associated diarrhoea: meta-analysis // BMJ. – 2002; 324 (7350): 1361.
  10. McCarthy J., O’Mahony L., Dunne C. et al. An open trial of a novel probiotic 11. as an alternative to steroids in mild/moderately active Crohn’s disease // Gut. – 2001; 49 (Suppl. 3): A2447.
  11. Liu Q., Duan Z., Ha da K. Synbiotic modulation of gut flora: effect on 12. minimal hepatic encephalopathy in patients with cirrhosis // Hepatology. – 2004; 39 (5): 1441–9.
  12. Li Z., Yang S., Lin H. Probiotics and antibodies to TNF inhibit inflammatory 13. activity and improve nonalcoholic fatty liver disease // Hepatology. – 2003; 37: 343–50.
  13. Reid G., Charbonneau D., Erb J. et al. Oral use of Lactobacillus rhamnosus 14. GR-1 and L. fermentum RC-14 significantly alters vaginal flora: randomized, placebo controlled trial in 64 healthy women // Immunol. Med. Microbiol. – 2003; 35 (2): 131–4.
  14. Marco M., Pavan S., Kleerezebem M. Towards understanding molecular 15. modes of probiotic action // Curr. Opin. Biotechnol. – 2006; 17: 204–10.
  15. Schlee M., Harder J., K16. öten B. Probiotic lactobacilli and VSL#3 induce enterocyte betadefensin 2 // Clin. Exp. Immunol. – 2008; 151 (3): 528–35.
  16. Bengmark S. Bioecological control of the gastrointestinal tract: the role of 17. flora and supplemented probiotics and synbiotics // Gastroenterol. Clin. North. Am. – 2005; 34: 413–36.
  17. Sheih Y., Chiang B., Wang L. Systemic immunity-enhancing effects in 18. healthy subjects following dietary consumption of the lactic acid bacterium Lactobacillus rhamnosus HN001 // J. Am. Coll. Nutr. – 2001; 20: 149–56.
  18. Niers L., Timmermann H., Rijkers G. Identification of strong interleukin-10 19. inducing lactic acid bacteria which down-regulate T helper type 2 cytokines // Clin. Exp. Allergy. – 2005; 35: 1481–9.
  19. Platell C., Hall J. What is the role of mechanical bowel preparation in 20. patients undergoing colorectal surgery? // Dis. Colon. Rectum. – 2011; 41: 875–82.
  20. Rayes N., Hansen S., Seehofer D. et al. Early enteral supply of fiber and 21. lactobacilli versus conventional nutrition: a controlled trial in patients with major abdominal surgery // Nutrition. – 2002; 18: 609–15.
  21. Nomura T., Tsuchiya Y., Nashimoto A. et al. Probiotics reduce infectious 22. complications after pancreaticoduodenectomy // Hepato-Gastroenterology. – 2007; 54: 661–3.
  22. Sugawara G., Nagino M., Nishio H. et al. Perioperative synbiotic treatment 23. to prevent postoperative infectious complications in biliary cancer surgery. A randomized controlled trial // Ann. Surg. – 2006; 244: 706–14.
  23. Aisu N., Tanimur S., Yamashita Y. et al. Impact of perioperative probiotic 24. treatment for surgical site infections in patients with colorectal cancer // Experimental and therapeutic medicine. – 2015; 10: 966–72.
  24. McNaught C., Woodcock N., MacFie J. A prospective randomised study of 25. the probiotic Lactobacillus plantarum 299v on indices of gut barrier function in elective surgical patients // Gut. – 2002; 51: 827–31.
  25. Anderson A., McNaught C., Jain P. Randomised clinical trial of synbiotic 26. therapy in elective surgical patients // Gut. – 2004; 53; 241–5.
  26. Reddy B., MacFie J., Gatt M. Randomized clinical trial of effect of synbiotics, 27. neomycin and mechanical bowel preparation on intestinal barrier function in patients undergoing colectomy // Br. J. Surg. – 2007; 94: 546–54.
  27. Rayes N., Seehofer D., Theruvath T. et al. Effect of enteral nutrition and 28. synbiotics on bacterial infection rates after pylorus preserving pancreatoduodenectomy // Ann. Surg. – 2007; 246: 36–41.
  28. Olah A., Belagyi T., Issekutz A. Randomized clinical trial of specific 29. Lactobacillus and fibre supplement to early enteral nutrition in patients with acute pancreatitis // Br. J. Surg. – 2002; 89: 1103–7.
  29. Olah A., Belagyi T., Poto L. Synbiotic control of inflammation and infection 30. in severe acute pancreatitis: a prospective, randomized, double-blind study // Hepato-Gastroenterology. – 2007; 54: 590–4.
  30. Besselink M., van Santvoort H., Buskens E. et al. Probiotic prophylaxis in 31. predicted severe acute pancreatitis: a randomised, double-blind, placebo-controlled trial // Lancet. – 2008; 371: 651–9.
  31. Kanazawa H., Nagino M., Kamiya S. et al. Synbiotics reduce postoperative 32. infectious complications: a randomized controlled trial in biliary cancer patients undergoing hepatectomy // Langenbecks. Arch. Surg. – 2005; 390: 104–13.
  32. Rayes N., Seehofer D., Hansen S. Early enteral supply of Lactobacillus and 33. fiber versus selective bowel decontamination: a controlled trial in liver transplant recipients // Transplantation. – 2002; 74 (1): 123–8.
  33. Kotzampassi K., Giamarellos-Bourboulis E., Voudouris A. et al. Benefits of a 34. synbiotic formula (Synbiotic 2000forte) in critically ill trauma patients: early results of a randomized controlled trial // World. J. Surg. –2006; 30: 1848–55.
  34. Spindler-Vesel A., Bengmark S., Vovk I. Synbiotics, prebiotics, glutamine, 35. or peptide in early enteral nutrition: a randomized study in trauma patients // J. Parent. Enteral. Nutr. – 2007; 31: 119–26.
  35. Reddy B., MacFie J., Gatt M. Randomized clinical trial of effect of synbiotics, 36. neomycin and mechanical bowel preparation on intestinal barrier function in patients undergoing colectomy // Br. J. Surg. –2007; 94: 546–54.
  36. Horvat M., Krebs B., Potrc S. Preoperative synbiotic bowel conditioning for 37. elective colorectal surgery // Wien. Klin. Wochenschr. – 2010; 122: 26–30.
  37. Eguchi S., Takatsuki M., Hidaka M. Perioperative synbiotic treatment to 38. prevent infectious complications in patients after elective living donor liver transplantation: A prospective randomized study // Am. J. Surg. – 2011; 201: 498–502.
  38. D'Souza B., Slack T., Wong S. Randomized controlled trial of probiotics 39. after colonoscopy // J. Surg. – 2015; 17: 102–23.
  39. Lee H., Kim Y., Kim J. A feasibility study of probiotics pretreatment as a 40. bowel preparation for colonoscopy in constipated patients // Dig. Dis. Sci. – 2010; 55 (8): 2344–51.
  40. Cruchet S., Furnes R., Maruy A. et al. The use of probiotics in pediatric 41. gastroenterology: a review of the literature and recommendations by latin-american experts // Paediatr. Drugs. – 2015; 17 (3): 199–216.
  41. de Vries M., Vaughan E., Kleerebezem M. et al. Lactobacillus plantarum-42. survival, functional and potential probiotic properties in the human intestinal tract // Int. Dairy J. – 2006; 16 (9): 1018–28.
  42. Collado M., Meriluoto J., Salminen S. In vitro analysis of probiotic strain 43. combinations to inhibit path