УЛУЧШЕНИЕ КОГНИТИВНЫХ ФУНКЦИЙ У ЗДОРОВЫХ ЛЮДЕЙ: ПРОБЛЕМЫ И ВОЗМОЖНОСТИ

Скачать статью в PDF
Номер журнала: 
12
Год издания: 
2015

Д. Сергеев, кандидат медицинских наук, М. Пирадов, член-корреспондент РАН Научный центр неврологии, Москва E-mail: dmsergeev@yandex.ru

Сегодня проблема улучшения когнитивных функций актуальна не только при их ухудшении вследствие того или иного заболевания, но и у здоровых людей, сталкивающихся с высокой интеллектуальной нагрузкой и вынужденных действовать в условиях дефицита времени на подготовку и принятие решений. К числу кандидатов на роль средств стимуляции интеллектуальной деятельности принадлежит препарат Цераксон (цитиколин). Он хорошо изучен, безопасен и обладает подтвержденной эффективностью в улучшении когнитивных функций у здоровых людей.
Ключевые слова: 
когнитивные функции
цитиколин
Цераксон
Для цитирования
Сергеев Д., Пирадов М. УЛУЧШЕНИЕ КОГНИТИВНЫХ ФУНКЦИЙ У ЗДОРОВЫХ ЛЮДЕЙ: ПРОБЛЕМЫ И ВОЗМОЖНОСТИ . Врач, 2015; (12): 11-13

It appears your Web browser is not configured to display PDF files. Download adobe Acrobat или click here to download the PDF file.

Список литературы: 
  1. Chatterjee A. Cosmetic neurology: The controversy over enhancing movement, mentation and mood // Neurology. – 2004; 63: 968–74.
  2. Chatterjee A. The promise and predicament of cosmetic neurology // J. Med. Ethics. – 2006; 32: 110–3.
  3. Hamilton R., Messing S., Chatterjee A. Rethinking the thinking cap. Ethics of neural enhancement using noninvasive brain stimulation // Neurology. – 2011; 76 (2): 187–93.
  4. Chatterjee A. The ethics of neuroenhancement. In: Handbook of Clinical Neurology, Vol. 118 (3rd series). Ethical and Legal Issues in Neurology. J.L. Bernat and R. Beresford (Eds). 2013; p. 323–34.
  5. Launis V. Cosmetic neurology: Sliding down the slippery slope? // Camb. Q. Healthc. Ethics. – 2010; 19 (2): 218–29
  6. Shaw D. Neuroenhancing public health // J. Med. Ethics. – 2014; 40: 6. 389–91.
  7. Cakic V. Smart drugs for cognitive enhancement: ethical andpragmatic considerations in the era of cosmeticneurology // J. Med. Ethics. – 2009; 35: 611–5.
  8. Maeda F., Pascual-Leone A. Transcranial magnetic stimulation: studying motor neurophysiology of psychiatric disorders // Psychopharmacology. – 2003; 168: 359–76.
  9. http://www.foc.us/
  10. https://www.sciencenews.org/article/home-brain-stimulation-gaining-10. followers
  11. Ohn S., Park CI., Yoo W. Time-dependent effect oftranscranial direct current 11. stimulation on the enhancementof working memory // Neuroreport. – 2008; 19: 43–7.
  12. Fregni F., Boggio P., Nitsche M. Anodal transcranial directcurrent stimulation of prefrontal cortex enhancesworking memory // Exp. Brain Res. – 2005; 166: 23–30.
  13. Kim Y., Park J., Ko M. et al. Facilitativeeffect of high frequency subthreshold repetitive transcranialmagnetic stimulation on complex sequential motorlearning in humans // Neurosci. Lett. – 2004; 367: 181–5.
  14. Nitsche M., Schauenburg A., Lang N. et al. Facilitation ofimplicit motor learning by weak transcranial direct currentstimulation of the primary motor cortex in the human // J. Cogn. Neurosci. – 2003; 15: 619–26.
  15. Kobayashi M., Hutchinson S., Th éoret H. et al. Repetitive TMS of the motor cortex improvesipsilateral sequential simple finger movements // Neurology. – 2004; 62: 91–8.
  16. Floel A., R16. össer N., Michka O. et al. Noninvasive brain stimulation improves language learning // J. Cogn. Neurosci. – 2008; 20: 1415–22.
  17. Hilgetag C., Th éoret H., Pascual-Leone A. Enhanced visualspatial attention ipsilateral to rTMS-induced ‘virtuallesions’ of human parietal cortex // Nat. Neurosci. – 2001; 4: 953–7.
  18. Lefaucheur J., André-Obadia N., Antal A. et al. Evidence-based guidelines on the therapeutic use of repetitive transcranialmagnetic stimulation (rTMS) // Clin. Neurophysiol. – 2014; 125: 2150–206.
  19. Червяков А.В., Пойдашева А.Г., Коржова Ю.Е. и др. Cовременные терапевтические возможности ритмической транскраниальной магнитной стиму-ляции в лечении заболеваний нервной системы // Рус. мед. журн. – 2014; 22 (22): 1567–72.
  20. George M., Wassermann E., Williams W. Changes inmood and hormone levels after rapid-rate transcranialmagnetic stimulation (rTMS) of the prefrontal cortex // J. Neuropsychiatry Clin. Neurosci. – 1996; 8: 172–80.
  21. Young L., Camprodon J., Hauser M. et al. Disruption of the right temporoparietaljunctionwith transcranial magnetic stimulation reduces the role ofbeliefs in moral judgements // Proc. Natl. Acad. Sci. USA. – 2010; 107: 6753–8
  22. Fecteau S., Knoch D., Fregni F. et al. Diminishing risk-taking behavior by modulatingactivity in the prefrontal cortex: a direct current stimulation study // J. Neurosci. – 2007; 27: 12500–5.
  23. Zeeuws I., Deroost N., Soetens E. Effect of an acute d-amphetamine administration on context information memory in healthy volunteers: evidence from a source memory task // Hum. Psychopharmacol. – 2010; 25: 326–34.
  24. Mintzer M., Griffiths R. Atriazolam/amphetamine dose – effect interaction study: dissociation of effects on memory versus arousal // Psychopharmacology. – 2007; 192: 425–40.
  25. Wardle M., Treadway M., Mayo L. et al. Amping up effort: effects of d-amphetamine on human effort-based decision-making // J. Neurosci. – 2011; 31: 16597–602.
  26. Caldwell J. Jr., Caldwell J., Smythe N. 3rd et al. A double-blind, placebo controlled investigation of the efficacy of modafinil for sustaining the alertness and performance of aviators: a helicopter simulator study // Psychopharmacology. – 2000; 150: 272–82.
  27. Battleday R., Brem A. Modafinil for cognitive neuroenhancement in healthy non-sleep-deprived subjects: A systematic review // Eur. Neuropsychopharmacol. – 2015, Aug 20.
  28. Baranski J., Pigeau R. Self-monitoring cognitive performance during sleep deprivation: effects of modafinil, d-amphetamine and placebo // J. Sleep Res. – 1997; 6: 84–91.
  29. Outram S. The use of methylphenidate among students: the future of enhancement? // J. Med. Ethics. – 2010; 36: 198–202.
  30. Leonard B., McCartan D., White J. et al. Methylphenidate: a review of . itsneuropharmacological, neuropsychological and adverse clinical effects // Hum. Psychopharmacol. Clin. Exp. – 2004; 19: 151–80.
  31. Repantis D., Laisney O., Heuser I. Acetylcholinesterase inhibitors and memantine for neuroenhancement in healthy individuals: A systematic review // Pharmacol. Res. – 2010; 61: 473–81.
  32. FitzGerald D., Crucian G., Mielke J. et al. Effects of donepezil on verbal memory after semantic processing in healthy older adults // Cogn. Behav. Neurol. – 2008; 21: 2.
  33. Gron G., Kirstein M., ThielscherA. et al. Cholinergic enhancement of episodic memory in healthy young adults // Psychopharmacology. – 2005; 182: 170–9.
  34. Chuah L., Chee M. Cholinergic augmentation modulates visual task performance in sleep-deprived young adults // J. Neurosci. – 2008; 28: 11369–77.
  35. Yesavage J., Mumenthaler M., Taylor J. et al. Donezepil and flight simulator performance: effects on retention of complex skills // Neurology. – 2001; 59: 123–5.
  36. McDaniel M., Maier S., Einstein G. «Brain-specific» nutrients: a memory cure? // Nutrition. – 2003; 19: 957–75
  37. Benton D., Fordy J., Haller J. The impact of long-term vitamin supplementation on cognitive functioning // Psychopharmacology. – 1995; 117: 298.
  38. Kennedy E. Sailing to Byzantium // Ann. Rev. Biochem. – 1992; 61: 1–28.38.
  39. Watanabe S., Kono S., Nakashima Y. et al. Effects of various cerebral metabolic activators on glucose metabolism of brain // Folia Psychiatr. Neurol. Jpn. – 1975; 29: 67–76.
  40. Martinet M., Fonlupt P., Pacheco H. Effects of cytidine-5’ diphosphocholine on norepinephrine, dopamine and serotonin synthesis in various regions of the rat brain // Arch. Int. Pharmacodyn. Ther. – 1973; 239: 52–61.
  41. Secades J., Frontera G. CDP-choline: pharmacological and clinical review // Methods Find Exp. Clin. Pharmacol. – 1995; 17 (Suppl. B): 1–54.
  42. Zafonte R., Bagiella E., Ansel B. et al: Effect of citicoline on functional and 42. cognitive status among patients with traumatic brain injury: Citicoline BrainInjury Treatment Trial (COBRIT) // JAMA. – 2012; 308: 1993–2000.
  43. Dávalos A., Alvarez-Sabin J., Castillo J. et al., InternationalCiticoline Trial on Acute Stroke (ICTUS) trial investigators: Citicoline in the treatment of acute ischemic stroke: an international, randomized, multicentre, placebocontrolledstudy (ICTUS trial) // Lancet. – 2012; 380: 349–5.
  44. Grieb P. Citicoline: A Food That May Improve Memory // Med. Sci. Rev. – 2015; 2: 67–72.
  45. Fioravanti M., Yanagi M. Cytidinediphosphocholine (CDP-choline) for cognitive and behavioral disturbances associated with chronic cerebral disorders in the elderly // Cochrane Database Syst. Rev. – 2005; 2: CD000269.Alvarez-Sabin
  46. J., Ortega G., Jacas C. et al: Long-term treatment with citicoline may improve poststroke vascular cognitive impairment // Cerebrovasc. Dis. – 2013; 35: 146–54.
  47. Babb S., Wald L., Cohen B. et al: Chronic citicoline increases phosphodiesters in the brains of healthy older subjects: an in vivo phosphorus magnetic resonance spectroscopy study // Psychopharmacology (Berl.). – 2002; 161: 248–54.
  48. Silveri M., Dikan J., Ross A. et al. Citicoline enhances frontal lobe bioenergetics as measured by phosphorus magnetic resonance spectroscopy // NMR Biomed. – 2008; 21: 1066–75.
  49. McGlade E. et al. Improved attentional performance following citicoline administration in healthy adult women // Food and Nutrition Sciences. – 2012; 3: 769–73.
  50. McGlade E., Agoston A., DiMuzio J. et al. The Effect of Citicoline Supplementation on Motor Speed and Attention in Adolescent Males // J. Atten. Disord. – 2015, Jul. 15.
  51. Bruce S. Improvements in quantitative EEG following consumption of a natural citicoline-enhanced beverage // Int. J. Food. Sci. Nutr. – 2012; 63 (4): 421–5.
  52. Bruce S., Werner K., Preston B. et al. Improvements in concentration, working memory and sustained attention following consumption of a natural citicoline-caffeine beverage // Int. J. Food Sci. Nutr. – 2014; 65 (8): 1003–7.