FEATURES CARBOHYDRATE METABOLISM DISORDERS ON THE BACKGROUND OF OBESITY IN CHILDREN AND TEENAGERS

DOI: https://doi.org/10.29296/25877305-2020-09-15
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Issue: 
9
Year: 
2020

Professor Yu. Samoilova(1), MD; T. Filippova(1); O. Oleynik(1); Professor D. Kudlay(2, 3), MD;
T. Sivolobova(1); E. Sagan(1); N. Diraeva(1) (1)Siberian State Medical University, Tomsk (2)NRC Institute of
Immunology FMBA of Russia, Moscow (3)I.M. Sechenov First Moscow State Medical University (Sechenov
University)

Obesity in children and adolescents is one of the urgent problems of modern health care. In almost all countries of the world marked increase in the number of children and adolescents are overweight or obesity. This is an important factor for the development of a variety of disorders of carbohydrate. In this regard, the active their detection is of great importance both for diagnosis and for subsequent tactics patients. The aim of our study was to investigate the prevalence of autoantibodies in children and adolescents with obesity as a predictor of disorders of carbohydrate metabolism. The study involved 60 children aged 5 to 18 years with a variety of disorders in the carbohydrate background obesity and normal weight. Estimated carbohydrate and lipid disorders, conducted genetic and immunological testing for autoantibodies. As a result, it was found that obese children disorders of carbohydrate and lipid metabolism are more pronounced than in children of normal weight. Autoantibodies are often determined in a group of obese children. Thus, obesity is an aggravating factor, and detection of autoantibody is an additional method of verification studies for carbohydrate disorders.
Keywords: 
endocrinology
obesity
carbohydrate disorders
diabetes mellitus
autoantibodies
children
teenagers

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References: 
  1. Sorvacheva T.N., Peterkova V.A., Titova L.N. i dr. Ozhirenie u podrostkov. Lechaschij vrach. 2006; 4: 50–4 [Sorvacheva T.N., Peterkova V.A., Titova L.N. et al. Ozhirenie u podrostkov. Lechashchiy vrach. 2006; 4: 50–4 (in Russ.)].
  2. Pavlovskaja E.V., Strokova T.V., Surkov A.G. i dr. Ozhirenie u detej i podrostkov – sovremennyj vzgljad na problemu. Voprosy detskoj dietologii. 2008; 6 (4): 27–36 [Pavlovskaya E.V., Strokova T.V., Surkov A.G. et al. Obesity in children and adolescents: a current view on the problem. Voprosy Detskoi Dietologii. 2006; 6 (4): 50–4 (in Russ.)].
  3. Agafonova O.V., Gritsenko T.A., Bogdanova Ju.V. i dr. Poliklinicheskaja terapija: Uchebnik. Pod red. D.I. Davydkina, Ju.V. Schukina. 2-e izd., pererab. i dop. M.: GEOTAR-Media, 2020; 840 s. [Agafonova O.V., Gritsenko T.A., Bogdanova Yu.V. i dr. Poliklinicheskaya terapiya: Uchebnik. Pod red. D.I. Davydkina, Yu.V. Shchukina. 2-e izd., pererab. i dop. M.: GEOTAR-Media, 2020; 840 s. (in Russ.)]. DOI: 10.33029/9704-5545-6-PLT-2020-1-840
  4. Mel'nichenko G.A., Romantsova T.I. Ozhirenie: epidemiologija, klassifikatsija, patogenez, klinicheskaja simptomatika i diagnostika. V kn. Ozhirenie: etiologija, patogenez, klinicheskie aspekty. Pod red. I.I. Dedova, G.A. Mel'nichenko. M.: MIA, 2006; 16–43 [Mel’nichenko G.A., Romantsova T.I. Ozhirenie: epidemiologiya, klassifikatsiya, patogenez, klinicheskaya simptomatika i diagnostika. V kn. Ozhirenie: etiologiya, patogenez, klinicheskie aspekty. Pod red. I.I. Dedova, G.A. Mel’nichenko. M.: MIA, 2006; 16–43 (in Russ.)].
  5. Pavlovskaja E.V., Kaganov B.S., Strokova T.V. Ozhirenie u detej i podrostkov – patogeneticheskie mehanizmy, klinicheskie projavlenija, printsipy lechenija. Mezhdunarodnyj zhurnal pediatrii, akusherstva i ginekologii. 2013; 3 (2): 67–79 [Pavlovskaya E.V., Kaganov B.S., Strokova T.V. Obesity in children and adolescents – pathogenesis, clinical manifestation, treatment strategy. International Journal of Pediatrics, Obstetrics and Gynecology. 2013; 3 (2): 67–79 (in Russ.)].
  6. Fiziologija endokrinnoj sistemy. Pod red. Dzh. Griffina, S. Ohedy. M.: Binom, 2008; 454–85 [Fiziologiya endokrinnoy sistemy. Pod red. Dzh. Griffina, S. Okhedy. M.: Binom, 2008; 454–85 (in Russ.)].
  7. Zimmet P., Alberti K.G., Kaufman F. et al. The metabolic syndrome in children and adolescents – an IDF consensus report. Pediatr Diabetes. 2007; 8 (5): 299–306. DOI: 10.1111/j.1399-5448.2007.00271.x
  8. Kaminski B.M., Klingensmith G.J., Beck R.W. et al. Body mass index at the time of diagnosis of autoimmune type 1 diabetes in children. J Pediatr. 2013; 162 (4): 736–40.e1. DOI: 10.1016/j.jpeds.2012.09.017
  9. Liu L.L., Lawrence J.M., Davis C. et al. Prevalence of overweight and obesity in youth with diabetes in USA: the SEARCH for Diabetes in Youth study. Pediatr Diabetes. 2010; 11 (1): 4–11. DOI: 10.1111/j.1399-5448.2009.00519.x
  10. Pulgaron E.R., Delamater A.M. Obesity and type 2 diabetes in children: epidemiology and treatment. Curr Diab Rep. 2014; 14 (8): 508. DOI: 10.1007/s11892-014-0508-y
  11. Klingensmith G.J., Pyle L., Arslanian S. et al. The presence of GAD and IA-2 antibodies in youth with a type 2 diabetes phenotype: results from the TODAY study. Diabetes Care. 2010; 33 (9): 1970–5. DOI: 10.2337/dc10-0373
  12. Dedov I.I., Shestakova M.V., Majorov A.Ju. i dr. «Algoritmy spetsializirovannoj meditsinskoj pomoschi bol'nym saharnym diabetom» pod red. I.I. Dedova, M.V. Shestakovoj, A.Ju. Majorova 9-j vypusk. Saharnyj diabet. 2019; 22 (S1–1): 1–144 [Dedov I.I., Shestakova M.V., Mayorov A.Y. et al. Standards of specialized diabetes care. Edited by Dedov I.I., Shestakova M.V., Mayorov A.Yu. 9th edition. Diabetes Mellitus. 2019; 22 (S1–1): 1–144 (in Russ.)]. DOI:10.14341/DM221S1
  13. Aznabaeva L.F., Farhutdinova L.M., Salihova A.F. Immunologicheskie aspekty pri ozhirenii i narushenie uglevodnogo obmena. Ross immunol zhurn. 2014; 8 (3): 434–7 [Aznabaeva L., Farkhutdinova L., Salikhova A. Immunological aspects of carbohydrate metabolism disorders obesity. Russ J Immunol. 2014; 8 (3): 434–7 (in Russ.)].
  14. Timofeev A.V., Koltunov I.E., Petrjajkina E.E. i dr. Differentsial'no-diagnosticheskaja tsennost' kombinatsij immunofljuorestsentnogo testa na antitela k ostrovkovym kletkam, radioimmunnogo testa na antitela k glutamatdekarboksilaze i immunofermentnogo testa na antitela k tirozinfosfataze. Saharnyj diabet. 2018; 21 (2): 74–83 [Timofeev A.V., Koltunov I.E., Petriaikina E.E. et al. Differential diagnostic utilities of combined testing for islet cell antibody, glutamic acid decarboxylase antibody, and tyrosine phosphatase antibody. Diabetes Mellitus. 2018; 21 (2): 74–83 (in Russ.)]. DOI: 10.14341/DM9364
  15. Timofeev A.V., Gorst K.A., Uvarov V.Ju. i dr. Diagnosticheskaja tsennost' primenjajuschihsja v Rossii metodov issledovanija antitel k antigenam β-kletok. Klassicheskij immunofljuorestsentnyj metod opredelenija antitel k ostrovkovym kletkam, radioimmunnyj metod opredelenija antitel k glutamatdekarboksilaze i immunofermentnye metody opredelenija antitel k tirozinfosfataze i insulinu. Saharnyj diabet. 2016; 19 (4): 331–40 [Timofeev A.V., Gorst K.A., Uvarov V.Y. et al. Diagnostic value of islet autoantibody assays practised in Russia. 1. Classic immunofluorescence islet cell antibody assay, immunoradiometric glutamic acid decarboxylase antibody assay, and ELISA tyrosine phosphatase antibody and insulin antibody assays. Diabetes Mellitus. 2016; 19 (4): 331–40 (in Russ.)]. DOI: 10.14341/DM8032
  16. Silko Ju.V., Nikonova T.V., Ivanova O.N. i dr. Latentnyj autoimmunnyj diabet vzroslyh: informativnost' autoantitel. Ter arh. 2016; 88 (10): 42–5 [Silko Y.V., Nikonova T.V., Ivanova O.N. Latent autoimmune diabetes of adults (LADA): The informative value of autoantibodies. Ter arkh. 2016; 88 (10): 42–5 (in Russ.)]. DOI: 10.17116/terarkh2016881042-45
  17. Fabris M., Zago S., Liguori M. et al. Anti-zinc transporter protein 8 autoantibodies significantly improve the diagnostic approach to type 1 diabetes: an Italian multicentre study on pediatric patients. Auto Immun Highlights. 2015; 6 (1–2): 17–22. DOI: 10.1007/s13317-015-0068-4
  18. Levy-Marchal C., Arslanian S., Cutfield W. et al. Insulin resistance in children: consensus, perspective, and future directions. J Clin Endocrinol Metab. 2010; 95 (12): 5189–98. DOI: 10.1210/jc.2010-1047
  19. Meah F.A., DiMeglio L.A., Greenbaum C.J. et al. The relationship between BMI and insulin resistance and progression from single to multiple autoantibody positivity and type 1 diabetes among TrialNet Pathway to Prevention participants. Diabetologia. 2016; 59 (6): 1186–95. DOI: 10.1007/s00125-016-3924-5
  20. Tosur M., Geyer S.M., Rodriguez H. et al. Ethnic differences in progression of islet autoimmunity and type 1 diabetes in relatives at risk. Diabetologia. 2018; 61 (9): 2043–53. DOI: 10.1007/s00125-018-4660-9
  21. Antvorskov J.C., Aunsholt L., Buschard K. et al. Childhood body mass index in relation to subsequent risk of type 1 diabetes-A Danish cohort study. Pediatr Diabetes. 2018; 19 (2): 265–70. DOI: 10.1111/pedi.12568