THE STATISTICAL SIGNIFICANCE OF THE CLINICAL RESEARCH RESULTS ON THE PINEAL GLAND PREPARATION (EPITHALAMIN)

DOI: https://doi.org/10.29296/25877305-2020-09-08
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Issue: 
9
Year: 
2020

Е. Vershinina(1, 2); G. Safarova(2), Doctor of Biological Sciences; I. Popovich(3), Doctor of
Biological Sciences; Professor V. Khavinson(1, 3), Corresponding Member of RAS (1)Pavlov Institute of
Physiology RAS, Saint Petersburg (2)Institute for Problems of Regional Economics, RAS, Saint Petersburg
(3)Saint Petersburg Institute of Bioregulation and Gerontology

The paper presents the mathematical processing results of the data obtained from a clinical research on the effectiveness of a peptide preparation isolated from the pineal gland of calves – Epithalamin – in the elderly. The methods used for the statistical analysis suggest that administration of Epithalamin contributes to a statistically significant reduction in the patients’ mortality as compared to the control group. These data are an important fact and an objective logical continuation of many years of experimental studies of the effect of the peptide preparation of the pineal gland on various indicators of aging and carcinogenesis in animals.
Keywords: 
clinical research
peptides
epithalamin
methods of mathematical statistics

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References: 
  1. Bjujul' A., Tsefel' P. SPSS: Iskusstvo obrabotki informatsii. Analiz statisticheskih dannyh i vosstanovlenie skrytyh zakonomernostej. SPb: Dia Soft JuP, 2005; 608 s. [Buyul A., Zöfel P. SPSS: The Art of Information Processing. Analysis of statistical data and restoration of hidden patterns. St. Petersburg: Dia Soft UP, 2005; 608 (in Russ.)].
  2. Glants S. Mediko-biologicheskaja statistika. M: Praktika, 1999; 459 s. [Glants S. Biomedical statistics. M: Practika, 1999; 459 (in Russ.)].
  3. Grigor'ev S.G., Korneenkov A.A., Popovich I.G. Vybor metoda matematiko-statisticheskogo dokazatel'stva effektivnosti peptidnogo preparata epifiza. Sovremennye problemy zdravoohranenija i meditsinskoj statistiki. 2019; 4: 115–26 [Grigoriev S.G., Korneyenkov A.A., Popovich I.G. Choice of the method of mathematical and stastistical proof of the efficacy of the pineal peptide preparation. Modern problems of healthcare and medical statistics. 2019; 4: 115–26 (in Russ.)]. DOI: 10.24411/2312-2935-2019-10084
  4. Korkushko O.V., Havinson V.H., Shatilo V.B. i dr. Peptidnyj geroprotektor iz epifiza zamedljaet uskorennoe starenie pozhilyh ljudej: rezul'taty 15-letnego nabljudenija. Bjull eksper biol med. 2011; 151 (3): 343–7 [Korkushko O.V., Khavinson V.Kh., Shatilo V.B. et al. The peptide geroprotector from the pineal gland slows the accelerated aging of older people: the results of a 15-year observation. Bull exp boil med. 2011; 151 (3): 343–7 (in Russ.)].
  5. Flejs Dzh. Statisticheskie metody dlja izuchenija tablits dolej i proportsij. M.: Finansy i statistika, 1989; 319 s. [Fleis J. Statistical methods for studying tables of proportions and proportions. M.: Finance and statistics, 1989; 319 (in Russ.)].
  6. Havinson V.H., Anisimov V.N. Peptidnye bioreguljatory i starenie. SPb: Nauka, 2003; 223 s. [Khavinson V.Kh., Anisimov V.N. Peptide bioregulators and ageing. St. Petersburg: Nauka, 2003; 223 (in Russ.)].
  7. Havinson V.H., Kuznik B.I., Ryzhak G.A. Peptidnye geroprotektory – epigeneticheskie reguljatory fiziologicheskih funktsij organizma. SPb: RGPU im. A.I. Gertsena, 2014; 271 s. [Khavinson V.Kh., Kuznik B.I., Ryzhak G.A. Peptide geroprotectors – epigenetic regulators of physiological functions. St.Petersburg: A.I. Herzen State Pedagogical University, 2014; 271 (in Russ.)].
  8. Sharashova E.E., Holmatova K.K., Gorbatova M.A. i dr. Primenenie analiza vyzhivaemosti v zdravoohranenii s ispol'zovaniem paketa statisticheskih programm SPSS. Nauka i Zdravoohranenie. Metodologija nauchnyh issledovanij. 2017; 5: 5–28 [Sharashova E.E., Kholmatova K.K., Gorbatova M.A. et al. Health Survival Analysis using the SPSS statistical software package. Science and Health. Research Methodology. 2017; 5: 5–28 (in Russ.)]
  9. Khavinson V.Kh. Peptides and Ageing. Neuroendocrin Lett Special Issue. 2002; 23 (Suppl. 3): 144.
  10. Karadeniz P.N., Ercan. I. Examining tests for comparing survival curves with right censored data. SiT. 2017; 18 (2): 311–28. Doi 10. 21307. https://doi.org/10.21307/stattrans-2016-072
  11. Statsoft Survival Failure Time Analysis [site]. URL: http://www.statsoft.com/Textbook/SurvivalFailure-Time-Analysis