The Journal is included in Russian and International Library and Abstract Databases
Russain Science Index (Russia)
EBSCO
DOI Registration Agency (USA)

Blood clinical and morphological parameters in prostate cancer in old age

DOI: https://doi.org/10.29296/25877305-2019-06-17
Issue: 
6
Year: 
2019

Professor T. Pavlova(1), MD; Professor V. Kulikovsky(1), MD; Professor K. Proshchaev(2), MD; I. Pavlov(1), Candidate of Medical Sciences; M. Chaplygina(1) 1-Belgorod State National Research University 2-Gerontology Research Medical Center, Moscow

Electron scanning microscopy and enzyme immunoassay were used to conduct a comprehensive study of blood characteristics in elderly patients with prostate cancer (PC). A total of 110 people divided into groups and subgroups, differing in age and nature of the extent of a tumor process, were examined. In apparently healthy elderly patients, the percentage of prehemolytic forms of erythrocytes were shown to be higher than that in middle-aged people. The elderly, also those with prostate pathologyy, versus the control group of the same age had lower content of discocytes, higher frequency of transitional forms of red blood cells, and their decreased average diameter. Tendencies toward changes in the concentration of biomarkers (TuM2Pk, interleukin-12, FGF, VEGF, tumor necrosis factor-α, and total prostate-specific antigen l) were also determined in elderly people with varying tumor extents in PC.

Keywords: 
oncology
erythrocytes
prostate cancer
scanning electron microscopy
atomic force microscopy
tumor-associated markers



References: 
  1. Mamaeva S.N., Munhalova Ja.A., Kononova I.V. i dr. Issledovanie eritrotsitov krovi metodom rastrovoj elektronnoj mikroskopii // Vestnik Mordovskogo universiteta. – 2016; 26 (3): 381–90 [Mamaeva S.N., Munkhalova Ya.A., Kononova I.V. et al. Study of red blood cells by scanning electron microscopy method // Bulletin of Mordovia University. – 2016; 26 (3): 381–90 (in Russ.)].
  2. Borovskaja M.K., Kuznetsova E.E., Gorohova V.G. i dr. Strukturno-funktsional'naja harakteristika membrany eritrotsita i ee izmenenija pri patologijah raznogo geneza // Bjulljuten' VSNTs SO RAMN. – 2010; 3 (73): 334–54 [Borovskaya M.K., Kuznetsova E.E., Gorokhova V.G. et al. Structural and functional characteristics of the erythrocyte membrane and its changes in pathologies of different genesis // Bulletin of the East-Siberian Scientific Center of the Siberian Branch of the Russian Academy of Medical Sciences. – 2010; 3 (73): 334–54 (in Russ.)].
  3. Nicolson G.. The Fluid–Mosaic Model of Membrane Structure: Still relevant to understanding the structure, function and dynamics of biological membranes after more than 40 years // Biochimica et Biophysica Acta (BBA) – Biomembranes. – 2014; 1838 (6): 1451–66.
  4. Sergeeva N.S., Marshutina N.V. Obschie predstavlenija oserologicheskihbiomarkerah i ih meste v onkologii // Prakticheskaja onkologija. – 2011; 12 (4): 147–54 [Sergeeva N.S., Marshutina N.V. General concepts of serological biomarkers and their place in oncology // Practical Oncology. – 2011; 12 (4): 147–54 (in Russ.)].
  5. Wu L., Gomes A., Sinclair D. Geroncogenesis: metabolic changes during aging as a driver of tumorigenesis // Cancer Cell. – 2014; 25 (1): 12–9.
  6. Merabishvili V.M. Vozrastnye riski vozniknovenija raka (analiticheskie pokazateli ucheta i rannej diagnostiki) // Uspehi gerontologii. – 2017; 30 (6): 818–25 [Merabishvili V.M. Age-related risks of cancer (analytical indicators of accounting and early diagnosis) // Successes of gerontology. – 2017; 30 (6): 818–25 (in Russ.)].