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The frequency and clinical aspects of Barrett’s esophagus in elderly patients


Professor V. Tsukanov(1), MD; Professor E. Onuchina(2), MD; A. Vasyutin(1), Candidate of Medical Sciences; Yu. Tonkikh1, Candidate of Medical Sciences 1-Krasnoyarsk Research Center, Siberian Branch, Russian Academy of Sciences, Separate Division «Research Institute for Medical Problems of the North» 2-Irkutsk State Medical Academy of Postgraduate Education, Branch, Russian Medical Academy of Continuing Professional Education, Ministry of Health of Russia

Barrett’s esophagus (BE) in elderly patients is a serious clinical problem. Attentive, qualified diagnosis, treatment, and prevention are required in BE. The frequency and clinical aspects of BE have been studied in elderly patients.

gastroesophageal reflux disease
Barrett’s esophagus
elderly patients

  1. Achem S., DeVault K. Gastroesophageal reflux disease and the elderly // Gastroenterol. Clin. North Am. – 2014; 43 (1): 147–60. DOI: 10.1016/j.gtc.2013.11.004.
  2. Johnson D., Fennerty M. Heartburn severity underestimates erosive esophagitis severity in elderly patients with gastroesophageal reflux disease // Gastroenterology. – 2004; 126 (3): 660–4. DOI: 10.1053/j.gastro.2003.12.001.
  3. Okimoto E., Ishimura N., Morito Y. et al. Prevalence of gastroesophageal reflux disease in children, adults, and elderly in the same community // J. Gastroenterol. Hepatol. – 2015; 30 (7): 1140–6. DOI: 10.1111/jgh.12899.
  4. Coleman H., Xie S., Lagergren J. The Epidemiology of Esophageal Adenocarcinoma // Gastroenterology. – 2018; 154 (2): 390–405. DOI: 10.1053/j.gastro.2017.07.046.
  5. Bashashati M., Sarosiek I., McCallum R. Epidemiology and mechanisms of gastroesophageal reflux disease in the elderly: a perspective // Ann. N. Y. Acad. Sci. –2016; 1380 (1): 230–4. DOI: 10.1111/nyas.13196.
  6. Vakil N., van Zanten S., Kahrilas P. et al. The Montreal definition and classification of gastroesophageal reflux disease: a global evidence-based consensus // Am. J. Gastroenterol. – 2006; 101 (8): 1900–20. DOI: 10.1111/j.1572-0241.2006.00630.x.
  7. Lundell L., Dent J., Bennet J. et al. Endoscopic assessment of oesophagitis: clinical and functional correlates and further validation of the Los Angeles classification // Gut. – 1999; 45 (2): 172–80. DOI: 10.1136/gut.45.2.172.
  8. Modlin I., Hunt R., Malfertheiner P. et al. Diagnosis and management of non-erosive reflux disease--the Vevey NERD Consensus Group // Digestion. – 2009; 80 (2): 74–88. DOI: 10.1159/000219365.
  9. Fitzgerald R., di Pietro M., Ragunath K. et al. British Society of Gastroenterology guidelines on the diagnosis and management of Barrett’s oesophagus // Gut. – 2014; 63 (1): 7–42. DOI: 10.1136/gutjnl-2013-305372.
  10. Tsukanov V.V., Onuchina E.V., Vasjutin A.V. i dr. Taktika vedenija bol'nyh gastroezofageal'noj refljuksnoj bolezn'ju s vnepischevodnymi sindromami // Farmateka. – 2015; 6: 11–4 [Tsukanov V.V., Onuchina E.V., Vasyutin A.V. et al. Management of GERD patients with extraesophageal syndromes // Farmateka. – 2015; 6: 11–4 (in Russ.)].
  11. Weusten B., Bisschops R., Coron E. et al. Endoscopic management of Barrett’s esophagus: European Society of Gastrointestinal Endoscopy (ESGE) Position Statement // Endoscopy. – 2017; 49 (2): 191–8. DOI: 10.1055/s-0042-122140.
  12. Shaheen N., Falk G., Iyer P. et al. ACG Clinical Guideline: Diagnosis and Management of Barrett’s Esophagus // Am. J. Gastroenterol. – 2016; 111 (1): 30–50. DOI: 10.1038/ajg.2015.322.
  13. Fock K., Talley N., Goh K. et al. Asia-Pacific consensus on the management of gastro-oesophageal reflux disease: an update focusing on refractory reflux disease and Barrett’s oesophagus // Gut. – 2016; 65 (9): 1402–15. DOI: 10.1136/gutjnl-2016-311715.
  14. Clermont M., Falk G. Clinical Guidelines Update on the Diagnosis and Management of Barrett’s Esophagus // Dig. Dis. Sci. – 2018; 63 (8): 2122–8. DOI: 10.1007/s10620-018-5070-z.
  15. Pohl H., Pech O., Arash H. et al. Length of Barrett’s oesophagus and cancer risk: implications from a large sample of patients with early oesophageal adenocarcinoma // Gut. – 2016; 65 (2): 196–201. DOI: 10.1136/gutjnl-2015-309220.
  16. Whiteman D., Appleyard M., Bahin F. et al. Australian clinical practice guidelines for the diagnosis and management of Barrett’s esophagus and early esophageal adenocarcinoma // J. Gastroenterol. Hepatol. – 2015; 30 (5): 804–20. DOI: 10.1111/jgh.12913.
  17. Rajendra S., Sharma P. Barrett’s Esophagus // Curr. Treat. Options Gastroenterol. – 2014; 12 (2): 169–82. DOI: 10.1007/s11938-014-0012-0.
  18. Pandey G., Mulla M., Lewis W. et al. Systematic review and meta-analysis of the effectiveness of radiofrequency ablation in low grade dysplastic Barrett’s esophagus // Endoscopy. – 2018; 50 (10): 953–60. DOI: 10.1055/a-0588-5151.
  19. Singh S., Garg S., Singh P. et al. Acid-suppressive medications and risk of oesophageal adenocarcinoma in patients with Barrett’s oesophagus: a systematic review and meta-analysis // Gut. – 2014; 63 (8): 1229–37. DOI: 10.1136/gutjnl-2013-305997.
  20. Freedberg D., Kim L., Yang Y. The Risks and Benefits of Long-term Use of Proton Pump Inhibitors: Expert Review and Best Practice Advice From the American Gastroenterological Association // Gastroenterology. – 2017; 152 (4): 706–15. DOI: 10.1053/j.gastro.2017.01.031.
  21. Wassenaar E., Oelschlager B. Effect of medical and surgical treatment of Barrett’s metaplasia // World J. Gastroenterol. – 2010; 16 (30): 3773–9. DOI: 10.3748/wjg.v16.i30.3773.
  22. Rayner C., Gatenby P. Effect of antireflux surgery for Barrett’s esophagus: long-term results // Minerva Chir. – 2016; 71 (3): 180–91.
  23. Rugge M., Genta R., Graham D. et al. Chronicles of a cancer foretold: 35 years of gastric cancer risk assessment // Gut. – 2016; 65 (5): 721–5. DOI: 10.1136/gutjnl-2015-310846.
  24. Tsukanov V.V., Amel'chugova O.S., Kasparov E.V. i dr. Rol' eradikatsii Helicobacter pylori v profilaktike raka zheludka // Ter. arh. – 2014; 86 (8): 124–7 [Tsukanov V.V., Amel’chugova O.S., Kasparov E.V. et al. Role of Helicobacter pylori eradication in the prevention of gastric cancer // Ter. Arkh. – 2014; 86 (8): 124–7 (in Russ.)].