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А. Lihtinova(1), Е. Korshun(2), Candidate of Medical Sciences 1-MD Beauty Clinic, Moscow 2-Federal scientific and clinical center of specialized types of medical care and medical technologies of the Federal medical biological Agency, Moscow

The article describes the application of cell cronoblocker in multimodal programmes for the prevention of early aging. Many studies confirm that the development of a number of diseases, such as hypertension, diabetes mellitus type II, osteoarthritis and others in middle-aged people is a direct consequence of the processes of premature aging. It is important to use measures to prevent premature aging. The particular interest for the preparation of preventive programs are present the cell chronoblockers, which capable of preventing premature aging by normalizing the internal potential and functioning of the cell, such as organic sulfur, beta-alanine, succinic acid, ubiquinone, dimethylaminoethanol and others. The importance of distinguishing the preparations of cellular chronobiology and study its properties as an effective complementary preventive components of the geriatric programs is promising.

cellular chronoblocker
age changes
early aging

  1. Il'nitskij A.N., Proschaev K.I., Trofimov S.V. i dr. Preventivnaja geriatrija, ili antivozrastnaja meditsina // Uspehi gerontologii. – 2015; 28 (3): 589–92 [Ilnitski A.N., Prashchayeu K.I., Trofimova S.V. et al. Preventive geriatrics vs anti-aging medicine // Uspekhi gerontologii. – 2015; 28 (3): 589–92 (in Russ.)].
  2. Il'nitskij A.N., Proschaev K.I., Korshun E.I. Kletochnye hronoblokatory i starenie golovnogo mozga // Gerontologija. – 2017; 1: 104–12 [Ilnitskii A.N., Prashchayeu K.I., Korshun E.I. Cellular chrono blockers and the aging of the brain // Uspekhi gerontologii. 2017; 1: 104–12 (in Russ.)]. Dostupno po / Available at:
  3. Gichev Ju.P. Ekologicheskaja obuslovlennost' prezhdevremennogo starenija i sokraschenija prodolzhitel'nosti zhizni naselenija Rossii // Gigiena i sanitarija. – 2002; 6: 48–51 [Gichev Yu.P. Ekologicheskaya obuslovlennost’ prezhdevremennogo stareniya i sokrashcheniya prodolzhitel’nosti zhizni naseleniya Rossii // Gigiena i sanitariya. – 2002; 6: 48–51 (in Russ.)].
  4. Darhan H., Zoda A., Kikusato M. et al. Correlations between mitochondrial respiration activity and residual feed intake after divergent genetic selection for high- and low- oxygen consumption in mice// Anim. Sci. J. – 2019; 3: 23–7.
  5. Zabihi F., Koeppe H., Achazi K. et al. One-Pot Synthesis of Poly (glycerol- co-succinic acid) Nanogels for Dermal Delivery // Biomacromolecules. – 2019; 6: 31–6.
  6. Wei L., Zhao X. A new MCM modification cycle regulates DNA replication initiation // Nat. Struct. Mol. Biol. – 2016; 23 (3): 209–16.
  7. De Andrade Kratz C., De Salles Painelli V., De Andrade Nemezio K. et al. Beta-alanine supplementation enhances judo-related performance in highly-trained athletes // J. Sci. Med. Sport. – 2017; 20 (4): 403–8.
  8. Garrido-Maraver J., Cordero M., Oropesa-Avila M. Clinical applications of coenzyme Q10 // Front Biosci (Landmark Ed). – 2014; 19: 619–33.
  9. Wang Y., Hekimi S. Understanding Ubiquinone // Trends Cell Biol. – 2016; 26 (5): 367–78.
  10. Jiao Y., Ma S., Li J. et al. N-Acetyl Cysteine (NAC)-Directed Detoxification of Methacryloxylethyl Cetyl Ammonium Chloride (DMEA-CB) // PLoS One. – 2015; 10 (8): 135–9.
  11. Malanga G., Aguiar M., Martinez H. et al. New insights on dimethylaminoethanol (DMEA) features as a free radical scavenger // Drug Metab. Lett. – 2012; 6 (1): 54–9.
  12. Stacy A., Belkaid Y. Microbial guardians of skin health // Science. – 2019; 363 (6424): 227–8.
  13. Umigai N., Murakami K., Ulit M. et al. The pharmacokinetic profile of crocetin in healthy adult human volunteers after a single oral administration // Phytomedicine. – 2011; 18 (7): 575–8.
  14. Devaraj S., Mathur S., Basu A. et al. A dose-response study on the effects of purified lycopene supplementation on biomarkers of oxidative stress // J. Am. Coll. Nutr. – 2008; 27 (2): 267–73