The pathogenesis of atrophic gastritis: immunological aspects

DOI: https://doi.org/10.29296/25877305-2019-05-08
Download full text PDF
Issue: 
5
Year: 
2019

Professor V. Tsukanov, MD; A. Vasyutin, Candidate of Medical Sciences; Yu. Tonkikh, Candidate of Medical Sciences; Associate Professor O. Smirnova, MD; A. Sinyakov, Candidate of Medical Sciences; O. Peretyatko, Candidate of Medical Sciences Federal Research Center «Krasnoyarsk Research Center, Siberian Branch, Russian Academy of Sciences», Separate Division, Research Institute for Medical Problems of the North, Krasnoyarsk

The features of cellular immunity in the blood of patients with atrophic body gastritis were investigated. A comparative study was conducted in 85 patients with moderate atrophic body gastritis, 25 patients with severe atrophic body gastritis, and 90 apparently healthy people at the age of 25 to 65 years who were examined. Atrophic gastritis was diagnosed, by determining serum pepsinogen-1 and pepsinogen-2 levels and morphologically examining the gastric mucosa. Cellular immunity in the blood was estimated by indirect immunofluorescence assay using monoclonal antibodies (CD3, CD4, CD8, and CD16). The serum concentration of immunoglobulins A, M, E, and G was determined by enzyme immunoassay. Patients with severe atrophic body gastritis were found to have lower levels of T lymphocytes, T helper cell subpopulations, blood CD4+/CD8+ ratios and IgA and IgG concentrations than healthy individuals.
Keywords: 
gastroenterology
atrophic gastritis
cellular immunity
lymphocytes

It appears your Web browser is not configured to display PDF files. Download adobe Acrobat или click here to download the PDF file.

References: 
  1. Rugge M., Sugano K., Scarpignato C. et al. Gastric cancer prevention targeted on risk assessment: Gastritis OLGA staging // Helicobacter. – 2019; 24 (2): e12571. DOI: 10.1111/hel.12571.
  2. Correa P. Gastric cancer: overview // Gastroenterol. Clin. North. Am. – 2013; 42 (2): 211–7. DOI: 10.1016/j.gtc.2013.01.002.
  3. Tsukanov V., Kasparov E., Tonkikh J. et al. Peptic Ulcer Disease and Helicobacter pylori Infection in Different Siberian Ethnicities // Helicobacter. – 2017; 22 (1): e12322. DOI: 10.1111/hel.12322.
  4. Tsukanov V.V., Amel'chugova O.S., Kasparov E.V. i dr. Rol' eradikatsii Helicobacter pylori v profilaktike raka zheludka // Ter. arh. – 2014; 86 (8): 124–7 [Tsukanov V.V., Amel’chugova O.S., Kasparov E.V. et al. Role of Helicobacter pylori eradication in the prevention of gastric cancer // Ter. Arkh. – 2014; 86 (8): 124–7 (in Russ.)].
  5. Rugge M., Genta R., Graham D. et al. Chronicles of a cancer foretold: 35-years of gastric cancer risk assessment // Gut. – 2016; 65 (5): 721–5. DOI: 10.1136/gutjnl-2015-310846.
  6. Liu H., Li P., Yang W. et al. Identification of non-invasive biomarkers for chronic atrophic gastritis from serum exosomal microRNAs // BMC Cancer. – 2019; 19 (1): 129. DOI: 10.1186/s12885-019-5328-7.
  7. Cappellesso R., Fassan M., Hanspeter E. et al. HER2 status in gastroesophageal cancer: a tissue microarray study of 1040 cases // Hum. Pathol. – 2015; 46 (5): 665–72. DOI: 10.1016/j.humpath.2015.02.007.
  8. Kaji K., Hashiba A., Uotani C. et al. Grading of Atrophic Gastritis is Useful for Risk Stratification in Endoscopic Screening for Gastric Cancer // Am. J. Gastroenterol. – 2019; 114 (1): 71–9. DOI: 10.1038/s41395-018-0259-5.
  9. Syrjänen K., Eskelinen M., Peetsalu A. et al. GastroPanel® Biomarker Assay: The Most Comprehensive Test for Helicobacter pylori Infection and Its Clinical Sequelae. A Critical Review // Anticancer Res. – 2019; 39 (3): 1091–104. DOI: 10.21873/anticanres.13218.
  10. Dixon M., Genta R., Yardley J. et al. Classification and grading of gastritis. The updated Sydney System. International Workshop on the Histopathology of Gastritis, Houston 1994 // Am. J. Surg. Pathol. – 1996; 20 (10): 1161–81.
  11. McMahon B., Bruce M., Koch A. et al. The diagnosis and treatment of Helicobacter pylori infection in Arctic regions with a high prevalence of infection: Expert Commentary // Epidemiol. Infect. – 2016; 144 (2): 225–33. DOI: 10.1017/S0950268815001181.
  12. Kao J., Zhang M., Miller M. et al. Helicobacter pylori immune escape is mediated by dendritic cell-induced Treg skewing and Th17 suppression in mice // Gastroenterology. – 2010; 138 (3): 1046–54.
  13. Wu J., Lee Y., Graham D. The eradication of Helicobacter pylori to prevent gastric cancer: a critical appraisal // Expert Rev. Gastroenterol. Hepatol. – 2019; 13 (1): 17–24. DOI: 10.1080/17474124.2019.1542299.
  14. Graham D. Helicobacter pylori update: gastric cancer, reliable therapy, and possible benefits // Gastroenterology. – 2015; 148 (4): 719–31.