MULTIPLEX ANALYSIS OF TUMOR MARKERS IN THE EARLY DIAGNOSIS OF RECURRENCES OF OVARIAN GRANULOSA CELL TUMORS

DOI: https://doi.org/10.29296/25877305-2019-02-06
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Issue: 
2
Year: 
2019

A. Solopova(1), MD; A. Surenkov(2); V. Moskvicheva(1); A. Vlasina(1) 1-I.M. Sechenov First Moscow State Medical University (Sechenov University) 2-National Medical Research Center of Hematology, Moscow

Tumor markers for ovarian granulosa cell tumors (OGCT) are an important and integral component of a comprehensive screening program for women in the recovery period after antitumor treatment. At the same time, many issues reflecting the clinical and laboratory significance of tumor markers in the early preclinical diagnosis and prognosis of OGCT recurrences have been studied insufficiently and remain an actual problem of rehabilitation in gynecological cancer patients.

Keywords: 
oncology
tumor markers
granulosa cell tumors
diagnosis of recurrences
rehabilitation



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References: 
  1. Bejshembaev A.M., Ljubimova N.V., Kushlinskij D.N. i dr. Granulezokletochnye opuholi jaichnikov i ingibin V // Bjull. eksperim. biologii i meditsiny. – 2010; 150 (11): 567–70 [Beyshembayev A.M., Lyubimova N.V., Kushlinskiy D.N. et al. Granulezokletochnyye opukholi yaichnikov i ingibin B // Byul. eksperim. biologii i meditsiny. – 2010; 150 (11): 567–70 (in Russ.)].
  2. Davydova I.Ju., Kuznetsov V.V., Trjakin A.A. i dr. Klinicheskie rekomendatsii po diagnostike i lecheniju neepitelial'nyh opuholej jaichnikov / M., 2014; 1–15 [Davydova I.YU., Kuznetsov V.V., Tryakin A.A. i dr. Klinicheskiye rekomendatsii po diagnostike i lecheniyu neepitelial'nykh opukholey yaichnikov / M., 2014; 1–15 (in Russ.)].
  3. Levin G., Zigron R., Haj-Yahya R. et al. Granulosa cell tumor of ovary: A systematic review of recent evidence // Eur. J. Obstet. Gynecol. Reprod. Biol. – 2018; 225: 57–61.
  4. Pectasides D. Pectasides E. Psyrri A. Granulosa cell tumor of the ovary // Cancer Treat. Reviews. – 2008; 34 (1): 1–12.
  5. Bejshembaev A.M., Hajlenko V.A., Ljubimova N.V. i dr. Diagnostika i lechenie retsidivov granulezokletochnyh opuholej jaichnikov // Opuholi reproduktivnoj sistemy. – 2009; 3–4: 112–6 [Beishembayev A.M., Khailenko V.A., Lyubimova N.V. et al. Recurrent ovarian granulosa cell tumors: diagnosis and treatment // Opukholi reproduktivnoy sistemy. – 2009; 3–4: 112–6 (in Russ.)].
  6. Lee In Ho, Choi Chel Hun, Hong Dae Gy et al. Clinicopathologic characteristics of granulosa cell tumors of the ovary: a multicenter retrospective study // J. Gynecol. Oncol. – 2011; 22 (3): 188–95.
  7. Sakr S., Abdulfatah E., Thomas S. et al. Granulosa cell tumors: novel predictors of recurrence in early-stage patients // Int. J. Gynecol. Pathol. – 2017; 36 (3): 240–52.
  8. Zubtsova Zh.I., Savvateeva E.N., Zubtsov D.A. i dr. Razrabotka mnogoparametricheskoj test-sistemy dlja diagnostiki onkologicheskih zabolevanij zhenskoj reproduktivnoj sistemy // Molekuljarnaja fizika, biologija, meditsina. – 2010; 2 (6): 16–22 [Zubtsova Zh.I., Savvateyeva Ye.N., Zubtsov D.A. et al. Razrabotka mnogoparametricheskoy test-sistemy dlya diagnostiki onkologicheskikh zabolevaniy zhenskoy reproduktivnoy sistemy // Molekulyarnaya fizika, biologiya, meditsina. – 2010; 2 (6): 16–22 (in Russ.)].
  9. Zazdravnaja A.V. Onkomarkery i ih klinicheskoe znachenie // Zdravoohranenie Jugry: opyt i innovatsii. – 2016; 2 (7): 26–32 [Zazdravnaya A.V. Onkomarkery i ikh klinicheskoye znacheniye // Zdravookhraneniye Yugry: opyt i innovatsii. - 2016; 2 (7): 26–32 (in Russ.)].
  10. Aarti Umranikar, Mili Saran, Nick Brook et al. Role of anti-Müllerian hormone in diagnosing granulosa cell tumour: a case report // Clinical Ovarian and Other Gynecologic Cancer. – 2013; 5 (2): 94–6.
  11. Kushlinskij N.E., Ljubimova N.V. Opuholevye markery. Obschaja harakteristika, klinicheskoe znachenie i rekomendatsii po ispol'zovaniju // Laboratornaja diagnostika. – 2016; 8: 62–77 [Kushlinskiy N.Ye., Lyubimova N.V. Opukholevyye markery. Obshchaya kharakteristika, klinicheskoye znacheniye i rekomendatsii po ispol'zovaniyu // Laboratornaya diagnostika. – 2016; 8: 62–77 (in Russ.)].
  12. Anttonen M., Farkkila A., Tauriala H. et al. Anti-Mullerian hormone inhibits growth of AMH type II receptor-positive human ovarian granulosa cell tumor cells by activating apoptosis // Lab. Invest. – 2011; 91: 1605–14.
  13. Färkkilä A., Koskela S., Bryk S. et al. The clinical utility of serum anti-Müllerian hormone in the follow-up of ovarian adult-type granulosa cell tumors-a comparative study with inhibin B // Int. J. Cancer. – 2015; 137: 1661–71.
  14. Mom C., Engelen M., Willemse P. et al. Granulosacell tumors of the ovary: the clinical valueof serum inhibin A and B levels in a large singlecenter cohort // Gynecol. Oncol. – 2007; 105: 365–72.
  15. Lyzikova Ju.A. Opredelenie antimjullerova gormona v norme i pri razlichnyh ginekologicheskih zabolevanijah // Problemy zdorov'ja i ekologii. – 2014; 3 (41): 67–72 [Lyzikova Yu. A. Detection of anti-müllerian hormone in women with and without various gynecologic diseases // Problemy zdorov'ya i ekologii. – 2014; 3 (41): 67–72 (in Russ.)].
  16. Chang H., Pahlavan N., Halpern E. et al. Serum Mullerian inhibiting substance/anti-Mullerian hormone levels in patients with adult granulose cell tumors directly correlate with aggregate tumor mass as determined by pathology or radiology // Gynecol. Oncol. – 2009; 114: 57–60.
  17. Vartanjan A.A. Zhelezodefitsitnye sostojanija, anemija i rak // Ross. bioter. zhurn. – 2017; 3: 14–20 [Vartanian A.A. Iron metabolism, ferroptosis and cancer // Russian Journal of Biotherapy. – 2017; 16 (3): 14-20 (in Russ.)].
  18. Kuznetsov I.A., Potievskaja V.I., Kachanov I.V. i dr. Rol' ferritina v biologicheskih sredah cheloveka // Sovremennye problemy nauki i obrazovanija. – 2017; 5: 206. [Kuznetsov I.A., Potievskaya V.I., Kachanov I.V. et al. Ferritin's role in biological circles of the person // Sovremennyye problemy nauki i obrazovaniya. – 2017; 5: 206 (in Russ.)].
  19. Haltia U., Hallamaa M., Tapper J. et al. Roles of human epididymis protein 4, carbohydrate antigen 125, inhibin B and anti-Müllerian hormone in the differential diagnosis and follow-up of ovarian granulosa cell tumors // Gynecol. Oncol. – 2017; 44: 83–9.
  20. Kerzhkovskaja N.S., Anurova O.A., Zhordania K.I. i dr. Granulezokletochnye opuholi jaichnikov: diagnostika, faktory prognoza i lechenie. XIII Ross. onkol. kongress. M., 2008; 218 s. [Kerzhkovskaya N.S., Anurova O.A., Zhordania K.I. et al. Granulezokletochnyye opukholi yaichnikov: diagnostika, faktory prognoza i lecheniye. XIII Rossiyskiy onkologicheskiy kongress. M., 2008; 218 p. (in Russ.)].
  21. Yesilyurt H., Tokmak A., Guzel A. et al. Parameters for predicting granulosa cell tumor of the ovary: a single center retrospective comparative study // Asian Pac. J. Cancer Prev. – 2014; 15 (19): 8447–50.