Use of native type II collagen as part of the multiagent Gibelli Flex Active
DOI: https://doi.org/10.29296/25877305-2018-12-08
Issue:
12
Year:
2018
The paper reviews studies of the active ingredients of biologically active additive (BAA) in the dietary supplement Gibelli Flex Active. The BAA components have anti-inflammatory, chondroprotective, antioxidant, and immunomodulatory effects in the treatment of patients with osteoarthritis and improve their mobility and quality of life. Gibelli Flex Active has a good safety profile and can be recommended to treat locomotor diseases in patients of any age.
Keywords:
rheumatology
osteoarthritis
native type II collagen
glucosamine
turmeric (Curcuma longa)
boswellic acids
Gibelli Flex Active
References:
- Alekseeva L.I. Osteoartroz – problema veka // Med. sovet. – 2013; 5: 2–3.
- Badokin V.V. Suschestvujut li hondroprotektivnye preparaty? // RMZh. – 2010; 30: 1848.
- Dydykina I.S., Dydykina P.S., Alekseeva O.G. Vklad mikroelementov (medi, margantsa, tsinka, bora) v zdorov'e kosti: voprosy profilaktiki i lechenija osteopenii i osteoporoza // Effektivnaja farmakoterapija. – 2013; 38: 42–9.
- Karateev A.E., Nasonova V.A. Vozmozhnosti povyshenija effektivnosti i bezopasnosti terapii patsientov s pojasnichnoj bol'ju // Farmateka. – 2013; 13: 75–7.
- Ktsoeva E.L., Gatagonova T.M., Ktsoeva S.A. Kombinirovannoe lechenie bol'nyh osteoartrozom kolennogo sustava s ispol'zovaniem vitamina S // Kubanskij nauchn. med. vestn. – 2013; 5 (140): 121–4.
- Nasonov E.L. Nesteroidnye protivovospalitel'nye preparaty / M., 2010.
- Svetlova M.S. Patogeneticheskoe lechenie osteoartroza kolennyh sustavov // Sovremennaja revmatologija. – 2012; 3: 1–5.
- Spirichev V.B. Vitaminy, vitaminopodobnye i mineral'nye veschestva. Spravochnik / M.: Miklom, 2004.
- Tret'jak L.N., Gerasimov E.M. Spetsifika vlijanija selena na organizm cheloveka i zhivotnyh (primenitel'no k probleme sozdanija selenosoderzhaschih produktov pitanija) // Vestnik Orenburgskogo gos. universiteta. – 2007; 12 (79): 136–45.
- Habarov A.A., Budko E.V., Lushov K.A. i dr. Tsink: aktual'nost' i harakteristiki biodobavok (obzor literatury) // Sovremennye problemy nauki i obrazovanija. – 2012; 3: [Elektronnyj resurs]. Rezhim dostupa http://science-education.ru/ru/article/view?id=6416
- Ausar S., Beltramo D., Castagna L. et al. Treatment of rheumatoid arthritis by oral administration of bovine tracheal type II collagen // Rheumat. Internat. – 2001; 20: 138–44.
- Bagchi D., Misner B., Bagchi M. et al. Effects of orally administered undenatured type II collagen against arthritic inflammatory diseases: a mechanistic exploration // Int. J. Clin. Pharmacol. Res. – 2002; 22: 101–10.
- Bakilan F., Armagan O., Ozgen M. et al. Effects of Native Collagen Type II Treatment // Eurasian J. Med. – 2016; 48: 95–101.
- Crowley D., Lau F., Sharma P. et al. Safety and efficacy of undenatured type II collagen in the treatment of osteoarthritis of the knee: a clinical trial // Int. J. Med. Sci. – 2009; 6: 312–21.
- Deberg M., Labasse A., Collette J. et al. One-year increase of Coll 2-1, a new marker of type II collagen degradation, in urine is highly predictive of radiological OA progression // Osteoarthritis Cartilage. – 2005; 13: 1059–65.
- Deberg M., Dubuc J., Labasse A. et al. One-year follow-up of Coll2-1, Coll2-1NO2 and myeloperoxydase serum levels in osteoarthritis patients after hip or knee replacement // Ann. Rheum. Dis. – 2008; 67: 168–74.
- Evcik D., Babaoğlu Ü. Osteoartrit Etyopatojenezi. Saridoğan M. (Editor). TanidanTedaviyeOsteoartrit / İstanbul: Nobel Tip Kitapevleri, 2007; 51–72.
- Jobin C., Bradham C., Russo M. et al. Curcumin blocks cytokine-mediated NF-kappa B activation and proinflammatory gene expression by inhibiting inhibitory factor I-kappa B kinase activity // J. Immunol. – 1999; 163: 3474–83.
- Jurenka J. Anti-inflammatory properties of curcumin, a major constituent of Curcuma longa: a review of preclinical and clinical research // Altern. Med. Rev. – 2009; 14 (2): 141–53.
- Huebner J., Williams J., Deberg M. et al. Collagen fibril disruption occurs early in primary guinea pig knee osteoarthritis // Osteoarthritis Cartilage. – 2010; 18: 397–405.
- Kimmatkar N., Thawani V., Hingorani L. et al. Efficacy and tolerability of Boswelliaserrata extract in treatment of osteoarthritis of knee – A randomized double blind placebo controlled trial // Phytomedicine. – 2003; 10: 3–7.
- Kobayashi N., Kostka G., Garbe J. et al. A comparative analysis of the fibulin protein family. Biochemical characterization, binding interactions, and tissue localization // J. Biol. Chem. – 2007; 282: 11805–16.
- Meulenbelt I., Kloppenburg M., Kroon H. et al. Urinary CTX-II levels are associated with radiographic subtypes of osteoarthritis in hip, knee, hand, and facet joints in subject with familial osteoarthritis at multiple sites: the GARP study // Ann. Rheum. Dis. – 2006; 65: 360–5.
- Scarpellini M., Lurati A., Vignati G. et al. Biomarkers, type II collagen, glucosamine and chondroitin sulfate in osteoarthritis follow-up: the «Magenta osteoarthritis study» // J. Orthopaed. Traumatol. – 2008; 9: 81–7.
- Sellam J., Berenbaum F. The role of synovitis in pathophysiology and clinical symptoms of osteoarthritis // Nat. Rev. Rheumatol. – 2010; 6: 625–35.
- Surh Y., Chun K., Cha H. et al. Molecular mechanisms underlying chemopreventive activities of anti-inflammatory phytochemicals: down-regulation of COX-2 and iNOS through suppression of NFkappa B activation // Mutat Res. – 2001; 480–481: 243268.
- Trentham D., Halpner A., Trentham R. et al. Treatment of rheumatoid arthritis using undenatured type II collagen // Original Internist. – 2002; 9: 12–5.
- Wei W., Zhang L., Xu J. et al. A multicenter, double-blind, randomized, controlled phase III Clinical trial of chicken type II collagen in rheumatoid arthritis // Arthritis Res. Ther. – 2009; 11: 180.