Hypovitaminosis D and chronic pain

DOI: https://doi.org/10.29296/25877305-2018-09-07
Download full text PDF
Issue: 
9
Year: 
2018

А. Koloskova, Professor O. Vorobyeva, MD I.M. Sechenov First Moscow State Medical University (Sechenov University)

Currently, there is a substantial evolution of knowledge about the physiological role of vitamin D. Its receptors are assumed to be involved in the mechanisms of pain generation. There have been a large number of studies revealing the significance of hypovitaminosis D primarily in chronic pain syndromes and diseases, in which musculoskeletal factors are dominant in the formation of pain. The paper highlights the present-day views on the association of pain with vitamin D levels in the body and reviews the studies conducted in this area.

Keywords: 
neurology
vitamin D
hypovitaminosis D
25(OH)D
chronic pain



It appears your Web browser is not configured to display PDF files. Download adobe Acrobat или click here to download the PDF file.

References: 
  1. Defitsit vitamina D u vzroslyh: diagnostika, lechenie i profilaktika. Klinicheskie rekomendatsii. ROSSIJSKAJa ASSOTsIATsIJa ENDOKRINOLOGOV FGBU «ENDOKRINOLOGIChESKIJ NAUChNYJ TsENTR» Ministerstva zdravoohranenija Rossijskoj Federatsii / M., 2015; 5–75.
  2. Lerner P., Sharony L., Miodownik C. Israel. Association between mental disorders, cognitive disturbances and vitamin D serum level: Current state // Clin. Nutr. ESPEN. – 2018; 23: 89–102. DOI: 10.1016/j.clnesp.2017.11.011.
  3. Gromova O.A., Torshin I.Ju.Vitamin D – smena paradigmy. Pod red. E.I. Guseva, I.N. Zaharovoj / M.: Toruspress, 2015; 297–355.
  4. Sun J. Vitamin D and mucosal immune function // Curr. Opin. Gastroenterol. – 2010; 26: 591–5. DOI: 10.1097/MOG.0b013e32833d4b9f.
  5. Sivri S. Vitamin D metabolism. Calcium and vitamin D metabolism / ITA, 2010; r. 256.
  6. Mal'tsev S.V., Mansurova G.Sh. Metabolizm vitamina D i puti realizatsii ego osnovnyh funktsij // Prakticheskaja meditsina. – 2014; 9 (85): 12–8.
  7. Norman A., Bouillon R. Vitamin D nutritional policy needs a vision for the future // Exp. Biol. Med. – 2010; 235 (9): 1034–45. DOI: 10.1258/ebm.2010.010014.
  8. Eyles D., Smith S., Kinobe R. et al. Distribution of the vitamin D receptor and 1 alpha-hydroxylase in human brain // J. Chem. Neuroanat. – 2005; 29 (1): 21–30.
  9. Global Burden of Disease Study 2013 Collaborators. Global, regional, and national incidence, prevalence, and years lived with disability for 301 acute and chronic diseases and injuries in 188 countries, 1990–2013: a systematic analysis for the Global Burden of Disease Study 2013 // Lancet. – 2015; 22: 743–800. DOI: https://doi.org/10.1016/S0140-6736(15)60692-4
  10. Reginato A., Coquia J. Musculoskeletal manifestations of osteomalacia and rickets // Best Pract. Res. Clin. Rheumatol. – 2003; 17: 1063–80.
  11. Holick M. Vitamin D deficiency // N. Engl. J. Med. – 2007; 357: 266–81.
  12. Plotnikoff G., Quigley JM. Prevalence of severe hypovitaminosis D in patients with persistent, nonspecific musculoskeletal pain // Mayo Clin. Proc. – 2003; 78: 1463–70.
  13. Pfeifer M., Begerow B., Minne H. Vitamin D and muscle function // Osteoporos Int. – 2002; 13: 187–94.
  14. Tague S., Smith P. Vitamin D receptor and enzyme expression in dorsal root ganglia of adult female rats: Modulation by ovarian hormones // J. Chem. Neuroanat. – 2011; 41: 1–12. DOI: 10.1016/j.jchemneu.2010.10.001.
  15. Tague S., Clarke G., Winter M. et al. Vitamin D deficiency promotes skeletal muscle hypersensitivity and sensory hyperinnervation // J. Neurosci. – 2011; 31: 13728–38. DOI: 10.1523/JNEUROSCI.3637-11.2011.
  16. Kjaergaard M., Eggen A., Mathiesen E. et al. Association between headache and serum 25-hydroxyvitamin D; the Tromsø Study: Tromsø 6 // Headache. – 2012; 52: 1499–505. DOI: 10.1111/j.1526-4610.2012.02250.x.
  17. Virtanen J., Giniatullin R., Mäntyselkä P. et al. Low serum 25-hydroxyvitamin D is associated with higher risk of frequent headache in middleaged and older men // Sci. Rep. – 2017; 7: 39697. DOI: 10.1038/srep39697.
  18. Wu Z., Malihi Z., Stewart A. et al. The association between vitamin D concentration and pain: a systematic review and meta-analysis // Public Health Nutr. – 2018; 21 (11): 2022–37. DOI: 10.1017/S1368980018000551.
  19. Hsiao M., Hung C., Chang K. et al. Is serum hypovitaminosis D associated with chronic widespread pain including fibromyalgia? A Headache 11 meta-analysis of observational studies // Pain Physician. – 2015; 18: 877–87.
  20. Zadro J., Shirley D., Ferreira M. et al. Mapping the Association between Vitamin D and Low Back Pain: A Systematic Review and Meta-Analysis of Observational Studies // Pain Physician. – 2017; 20 (7): 611–40.
  21. Atherton K., Berry D., Parsons T. et al. Vitamin D and chronic widespread pain in a white middle-aged British population: evidence from a cross-sectional population survey // Ann. Rheum. Dis. – 2009; 68 (6): 817–22. DOI: 10.1136/ard.2008.090456.
  22. Johansen J., Manniche C., Kjaer P. Vitamin D levels appear to be normal in Danish patients attending secondary care for low back pain and a weak positive correlation between serum level Vitamin D and Modic changes was demonstrated: a cross-sectional cohort study of consecutive patients with non-specific low back pain // BMC Musculoskelet Disord. – 2013; 14: 78. https://doi.org/10.1186/1471-2474-14-78
  23. Ghai B., Bansal D., Kapil G. et al. High Prevalence of Hypovitaminosis D in Indian Chronic Low Back Patients // Pain Physician. – 2015; 18 (5): 853–62.
  24. Okumus M., Koybasi M., Tuncay F. et al. Fibromyalgia syndrome: is it related to vitamin D deficiency in premenopausal female patients? // Pain Manag. Nurs. – 2013; 14 (4): 156–63. DOI: 10.1016/j.pmn.2011.09.006.
  25. Wu Z., Malihi Z., Stewart A. et al. Effect of vitamin D supplementation on pain: a systematic review and metaanalysis // Pain Physician. – 2016; 19: 415–27.
  26. Akyuz G., Sanal-Toprak C., Yagci I. et al. The effect of vitamin D supplementation on pain, quality of life, and nerve conduction studies in women with chronic widespread pain // Int. J. Rehabil. Res. – 2017; 40 (1): 76–83. DOI: 10.1097/MRR.0000000000000211.
  27. Gendelman O., Itzhaki D., Makarov S. et al. A randomized double-blind placebo-controlled study adding high dose vitamin D to analgesic regimens in patients with musculoskeletal pain // Lupus. – 2015; 24: 483–9. DOI: 10.1177/0961203314558676.
  28. Yilmaz R., Salli A., Cingoz H. et al. Efficacy of vitamin D replacement therapy on patients with chronic nonspecific widespread musculoskeletal pain with vitamin D deficiency // Int. J. Rheum. Dis. – 2016; 19: 1255–62. DOI: 10.1111/1756-185X.12960.
  29. Prakash S., Makwana P., Rathore C. Vitamin D deficiency mimicking chronic tension-type headache in children // BMJ Case Rep. – 2016; 2: 2016. DOI: 10.1136/bcr-2015-213833.
  30. Dogru A., Balkarli A., Cobankara V. et al. Effects of Vitamin D Therapy on Quality of Life in Patients with Fibromyalgia // Eurasian J. Med. – 2017; 49 (2): 113–7. DOI: 10.5152/eurasianjmed.2017.16283.
  31. Al-Jarallah K., Shehab D., Abraham M. et al. Musculoskeletal pain: should physicians test for vitamin D level? // Int. J. Rheum. Dis. – 2013; 16: 193–7. DOI: 10.1111/1756-185X.12066.
  32. Knutsen K., Madar A., Brekke M. et al. Effect of vitamin D on musculoskeletal pain and headache: a randomized, double-blind, placebo-controlled trial among adult ethnic minorities in Norway // Pain. – 2014; 155: 2591–8.
  33. Wepner F., Scheuer R., Schuetz-Wieser B. et al. Effects of vitamin D on patients with fibromyalgia syndrome: a randomized placebo-controlled trial // Pain. – 2014; 155 (2): 261–8.
  34. Straube S., Derry S., Straube C. et al. Vitamin D for the treatment of chronic painful conditions in adults // Cochrane Database Syst. Rev. – 2015; CD007771.
  35. Straube S., Andrew Moore R., Derry S. et al. Vitamin D and chronic pain // Pain. – 2009; 141: 10–3.