RELEVANCE OF THE SAFETY OF THERAPY FOR OSTEOARTHRITIS IN GERIATRIC PRACTICE

DOI: https://doi.org/10.29296/25877305-2018-06-16
Download full text PDF
Issue: 
6
Year: 
2018

Professor E. Belyaeva, MD Medical Institute, Tula State University

The incidence of osteoarthritis is steadily increasing with age. It is impossible to consider drug therapy in elderly patients only from the standpoint of its efficiency; one of its main requirements is safety for short-term and long-term use. The undoubted advantages of Traumeel S are its multicomponent and multidirectional bioregulatory effects, good tolerance, compatibility with other drugs, and analgesic and anti-inflammatory activities in the absence of side effects characteristic of nonsteroidal anti-inflammatory drugs.
Keywords: 
therapy
osteoarthritis
geriatrics
safety of pharmacotherapy
Traumeel S
Zeel T

It appears your Web browser is not configured to display PDF files. Download adobe Acrobat или click here to download the PDF file.

References: 
  1. Revmatologija. Farmakoterapija bez oshibok.Pod. red. V.I. Mazurova, O.M. Lesnjak / E-noto, 2017; 528 s.
  2. Lesnjak O.M. i dr. Osteoartroz krupnyh sustavov nizhnih konechnostej / M.: GEOTAR-Media, 2016; 144 s.
  3. Shkola zdorov'ja. Osteoartrit: rukovodstvo dlja vrachej. Pod red. O.M. Lesnjak / M.: GEOTAR-Media, 2008; 104 s.
  4. Holla J., van der Leeden M. et al. The association of body-mass index and depressed mood with knee pain and activity limitations in knee osteoarthritis // BMC Musculoskelet. Disord. – 2013; 14: 296.
  5. Richette P., Poitou C., Garnero P. et al. Benefits of massive weight loss jn symptoms, systemic inflammation and cartilage turnover in obese patients with knee osteoarthritis // Ann. Rheum. Dis. – 2011; 70 (1): 139–44.
  6. Blackham J., Garry J., Cammings D. Does regular exercise reduce the pain and stiffness of osteoarthritis? // J. Fam. Pract. – 2008; 57 (Suppl. 7): 476–7.
  7. Doi T., Akai M., Fujino K. et al. Effect of home exercise of quadriceps on knee osteoarthritis compared with nonsteroidal antiinflammatory drugs: a randomized controlled trial // Am. J. Phis. Med. Rehabil. – 2008; 8 (Suppl. 4): 258–69.
  8. Hochberg M., Altman R. et al. American College of Rheumatologi 2012 recommendations for the use of nonpharmacologic and pharmacologic therapies in osteoarthritis of the hand, hip, and knee // Arthritis Care Res. (Hobocen). – 2012; 64 (4): 465–74.
  9. Karateev A.E., Lila A.M. Osteoartrit: sovremennaja klinicheskaja kontseptsija i nekotorye perspektivnye terapevticheskie podhody // Nauchno-prakt. revmatol. – 2018; 56 (1): 70–84.
  10. Rukovodstvo po gerontologii. Pod. red. V.N. Shabalina / M.: Tsitadel'-Trejd, 2005; 800 s.
  11. Elisjutkina S.V., Avdeeva O.S. Ratsional'naja farmakoterapija u patsientov pozhilogo i starcheskogo vozrasta // Klin. meditsina i farmakologija. – 2015; 1: 58–62.
  12. Sovremennye printsipy farmakoterapii v geriatricheskoj praktike. Metodicheskoe rukovodstvo / SPb, 2000; 36 s.
  13. Oslozhnenija farmakoterapii. Neblagoprijatnye pobochnye reaktsii lekarstvennyh sredstv. T. 1. Pod red. D.V. Rejharta / M.: Litterra, 2007; 256 s.
  14. Shamugija B.K., Timoshkov M.V. Bioreguljatsionnyj podhod k lecheniju boli // Therapia. – 2013; 2 (77): 75–8.
  15. Klimenko V.G. Osnovnye polozhenija patogeneticheskogo bioreguljatsionnogo podhoda v obschej terapevticheskoj praktike // Biol. terapija. – 2013; 1: 8–11.
  16. Beljaeva E.A, Agasarov L.G. Chastnye voprosy antigomotoksicheskoj terapii // Klin. meditsina i farmakologija. – 2017; 3 (2): 31–4.
  17. Hajne H., Shmol'ts M.V. Immunologicheskaja vspomogatel'naja reaktsija, vyzyvaemaja rastitel'nymi ekstraktami, soderzhaschimisja v antigomotoksicheskih preparatah // Biol. meditsina. – 1998; 2: 9–11.
  18. Hajne H. Znachenie antigomotoksicheskoj terapii v reguljatornoj meditsine // Biol. meditsina. – 2004; 2: 4–9.
  19. Van Brandt B., Hajne H. Reguljatornaja blokada: opredelenie, znachenie i terapija // Biol. meditsina. – 2006; 2: 4–5.
  20. Lozada C., del Rio E., Reitberg D. et al. A multi-center double-blind, randomized, controlled trial (db-RCT) to evaluate the effectiveness and safety of co-administered Traumeel (Tr14) and Zeel (Ze14) intra-articular (IA) injection versus IA placebo in patients with moderate-to-severe pain associated with OA of the knee // Arthritis Rheumatol. – 2014; 66 (suppl): 1266. Abstract no. 2896.
  21. Heine H., Schmolz M. Induction of the immunological bystander reaction by plant extracts // Biomed. Ther. – 1998; 16 (3): 224–6.
  22. Porozov S., Cahalon L., Weiser M. et al. Inhibition of IL-1 and TNF-α secretion from resting and activated human immunocytes by the homeopathic medication Traumeel S // Clin. Dev. Immunol. – 2004; 11 (2): 143–9.
  23. Bannuru R., Schmid C., Kent D. et al. Comparative effectiveness of pharmacologic interventions for knee osteoarthritis: a systematic review and network meta-analysis // Ann. Intern. Med. – 2015; 162 (1): 46–54.
  24. Gonzalez de Vega C., Gonzalez J. On behalf of Traumeel Acute Ankle Sprain Spain Study (TAASS) Investigators. A randomized, controlled, multicenter study on the effectiveness of Traumeel in terms of pain reduction and function improvement compared with diclofenac gel in acute ankle sprain // Ann. Rheum. Dis. – 2012; 71 (Suppl. 3): Abstract (SATO423).
  25. Thiel W., Borho B. Posttraumatische Kniegelenksergusse und intraartikulare Traumeel-Injektion // Orthopadische Praxis. – 1991; 11: 721–5.
  26. Orizola A., Vargas F. The efficacy of Traumeel versus diclofenac and placedo ointment in tendinous pain in elite athletes: a randomized controlled trial // Med. Sci. Sports Med. Exerc. – 2007; 39 (Suppl. 5): 79.
  27. Klinicheskij obraz preparata Traumel' S // Biol. terapija. – 2006; 1: 22–3.
  28. Monografija po preparatu Traumel' S. Per. s angl. / M.: Arnebija, 2011; 53 s.
  29. Popovich S.V., Ivanushko O.V. Traumel' S: bioreguljatsionnyj podhod k protivobolevoj terapii pozvonochnika i sustavov // Pract. Med. – 2016; 3 (23): 51–6.