CYP3A5*3 GENE POLYMORPHISM AND HALOPERIDOL EQUILIBRIUM CONCENTRATION IN ALCOHOL DEPENDENCE

Download full text PDF
Issue: 
9
Year: 
2017

M. Zastrozhin, Candidate of Medical Sciences; A. Chernikov; Associate Professor E. Grishina, Candidate of Biological Sciences; I. Miroshnichenko, MD; N. Baimeeva; D. Kubarev; A. Romanov, Candidate of Medical Sciences; M. Vdovina; Associate Professor L. Savchenko, Candidate of Medical Sciences; Professor E. Bryun, MD; Professor D. Sychev, Corresponding Member of the Russia Academy of Sciences Moscow Research and Practical Center for Narcology

The investigation has shown that CYP3A5*3 polymorphism has no significant impact on CYP3A4 activity and haloperidol equilibrium concentration in patients with alcohol dependence.
Keywords: 
psychiatry-narcology
haloperidol
biotransformation
CYP3A5*3
CYP3A4
adverse drug reactions
pathological alcohol craving
equilibrium concentration

It appears your Web browser is not configured to display PDF files. Download adobe Acrobat или click here to download the PDF file.

References: 
  1. Prikaz Ministerstva zdravoohranenija Rossijskoj Federatsii ot 4 sentjabrja 2012 g. №133n «Ob utverzhdenii standarta spetsializirovannoj meditsinskoj pomoschi pri sindrome zavisimosti, vyzvannom upotrebleniem psihoaktivnyh veschestv».
  2. Ivanets N.N. Narkologija: natsional'noe rukovodstvo. Pod red. N.N. Ivantsa, I.P. Anohinoj, M.A. Vinnikovoj / M.: GEOTAR-Media, 2008; 496 s. (Ser. «Natsional'nye rukovodstva»).
  3. Fang J., McKay G., Song J. et al. In vitro characterization of the metabolism of haloperidol using recombinant cytochrome p450 enzymes and human liver microsomes // Drug Metab. Dispos. – 2001; 29: 1638–43.
  4. Ghosh C., Marchi N., Desai N. et al. Cellular localization and functional significance of CYP3A4 in the human epileptic brain // Epilepsia. – 2011; 52: 562–71.
  5. Sychev D.A., Zastrozhin M.S., Smirnov V.V. i dr. Assotsiatsija aktivnosti izofermenta CYP2D6 s profilem effektivnosti i bezopasnosti galoperidola u patsientov, stradajuschih patologicheskim vlecheniem k alkogolju // Vestnik Ros. gos. med. universiteta. – 2015; 4: 36–9.
  6. Zastrozhin M.S., Grishina E.A., Sychev D.A. i dr. Izuchenie vlijanija geneticheskogo profilja na effektivnost' i bezopasnost' galoperidola u patsientov, stradajuschih alkogol'noj zavisimost'ju // Arh. vnutr. meditsiny. – 2016; T. 6, № 4 (30): 36–41.
  7. Zastrozhin M.S., Ryzhikova K.A., Avdeeva O.N. i dr. Vzaimosvjaz' polimorfizma gena, kodirujuschego izoferment tsitohroma P-450 2D6, s profilem effektivnosti i bezopasnosti galoperidola u patsientov, stradajuschih alkogol'nyj zavisimost'ju // Vestnik Volgogradskogo gos. med. universiteta. – 2016; 2 (58): 41–4.
  8. Sychev D., Zastrozhin M., Smirnov V. et al. the correlation between CYP2D6 isoenzyme activity and haloperidol efficacy and safety profile in patients with alcohol addiction during the exacerbation of the addiction // Pharmacogenomics and Personalized Medicine. – 2016; 9: 1–7.
  9. Zastrozhin M., Ryzhikova K., Avdeeva O. i dr. Assotsiatsija polimorfizma gena CYP2D6 s profilem effektivnosti i bezopasnosti galoperidola pri alkogol'noj zavisimosti // Vrach. – 2016; 3: 70–2.
  10. Zastrozhin M.S., Smirnov V.V., Sychev D.A. i dr. Vzaimosvjaz' aktivnosti izofermenta tsitohroma P-450 3A4 s profilem effektivnosti i bezopasnosti galoperidola u patsientov, stradajuschih patologicheskim vlecheniem k alkogolju // Ros. mediko-biol. vestn. im. akad. I.P. Pavlova. – 2015; 4: 51–6