MODERN BIOMARKERS OF AGING AND COGNITIVE DISORDERS

Download full text PDF
Issue: 
6
Year: 
2017

E. Hammad, Candidate of Medical Sciences Medical rehabilitation center, Moscow

The article presents the review of modern new biomarkers of aging. We have given the promising capabilities of biomolecular medicine in the early diagnosis of cognitive disorders. We presents the data on this new marker as an unconjugated bilirubin, end products of glycation, metalloprotein, DNA methylation, microRNA.
Keywords: 
gerontology
biomarkers of aging
cognitive impairment
early diagnosis
an unconjugated bilirubin
end products of glycation
metalloprotein
DNA methylation
microRNA

It appears your Web browser is not configured to display PDF files. Download adobe Acrobat или click here to download the PDF file.

References: 
  1. Havinson V.H., Lin'kova N.S., Trofimov A.V. i dr. Morfofunktsio- nal'nye osnovy peptidnoj reguljatsii starenija // Uspehi sovrem. biol. – 2011; 131 (2): 115–21.
  2. Pal'tsev M.A., Kvetnoj I.I. Rukovodstvo po nejroimmunoendokrinologii / M.: Meditsina, 2006; 384 s.
  3. Larner A. Neurological signs of possible diagnostic value in the cognitive disorders clinic// Pract. Neurol. – 2014; 14 (5): 332–5.
  4. Schlogl M., Holick M. Vitamin D and neurocognitive function // Clin. Interv. Aging. – 2014; 2 (9): 76–93.
  5. Mirza S., Koudstaal P. The N-terminal pro B-type natriuretic peptide, and risk of dementia and cognitive decline: a 10-year follow-up study in the general population // J. Neurol. Neurosurg. Psychiatry. – 2016; 87 (4): 356–62.
  6. McCarty M. Serum bilirubin may serve as a marker for increased heme oxygenase activity and inducibility in tissues – a rationale for the versatile health protection associated with elevated plasma bilirubin // Med. Hypotheses. – 2013; 81 (4): 607–10.
  7. Xue J., Ray R., Singer D. et al. The receptor for advanced glycation end products (RAGE) specifically recognizes methylglyoxal-derived AGEs // Biochemistry. – 2014; 53 (20): 3327–35.
  8. Ashraf J., Ahmad S., Choi I. Recent advances in detection of AGEs: Immunochemical, bioanalytical and biochemical approaches // IUBMB Life. – 2015; 67 (12): 897–913.
  9. Jahan H., Choudhary M. Glycation, carbonyl stress and AGEs inhibitors: a patent review // Exp. Opin. Ther. Pat. – 2015; 25 (11): 1267–84.
  10. Martin D., Grocott M. Oxygen therapy in critical illness: precise control of arterial oxygenation and permissive hypoxemia // Crit. Care Med. – 2013; 41 (2): 423–32.
  11. Frijhoff J., Winyard P., Zarkovic N. Clinical Relevance of Biomarkers of Oxidative Stress // Antioxid. Redox. Signal. – 2015; 23 (14): 1144–70.
  12. Avdagić N., Zaćiragić A., Babić N. Nitric oxide as a potential biomarker in inflammatory bowel disease // Bosn. J. Basic Med. Sci. – 2013; 13 (1): 5–9.
  13. Thirumoorthy N., Shyam Sunder A., Manisenthil Kumar K. A review of metallothionein isoforms and their role in pathophysiology // World J. Surg. Oncol. – 2011; 9: 54–62.
  14. Pashkovskiy P., Ryazansky S. Biogenesis, evolution, and functions of plant microRNAs // Genetics. – 2013; 13 (5): 1156–9.
  15. Buermans H., Ariyurek Y., Van Ommen G. New methods for next generation sequencing based microRNA expression profiling // BMC Genomics. – 2010; 11: 716.