CIRCULATING TUMOR CELLS IN COLORECTAL CANCER

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Issue: 
5
Year: 
2017

Professor O. Kit, MD, Corresponding Member of the Russian Academy of Sciences; P. Shulikov; I. Novikova, Candidate of Medical Sciences; A. Grankina; V. Kolesnikov, Candidate of Medical Sciences; Professor Yu. Gevorkyan, MD: Professor N. Soldatkina, MD Rostov Research Oncology Institute

The paper presents the results of investigating the detection rate and number of circulating tumor cells (CTCs) in the peripheral blood of patients with metastatic and non-metastatic colorectal cancer. The investigation revealed interesting differences between the groups. The findings prove the possibility and feasibility of using the level of CTCs as a predictor for the clinical course of a tumor process.
Keywords: 
oncology
circulating tumor cells
metastatic colorectal cancer and non-metastatic colorectal cancer

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References: 
  1. Kaprin A.D., Starinskij V.V., Petrova G.V. Sostojanie onkologicheskoj pomoschi naseleniju Rossii v 2014 godu / M.: MNIOI im. P.A. Gertsena – filial FGBU «NMIRTs» Minzdrava Rossii, 2015; 236 s.
  2. Kit O.I., Novikova I.A., Bahtin A.V. i dr. Pervyj opyt detektsii tsirkulirujuschih opuholevyh kletok v perifericheskoj krovi // Mezhdunarodn. zhurn. eksperim. obraz. – 2013; 11-2: 37–9.
  3. Kolesnikov V.E., Kit O.I., Zlatnik E.Ju. i dr. Analiz immunnogo statusa bol'nyh kolorektal'nym rakom posle razlichnyh variantov operativnogo vmeshatel'stva // Sovr. problemy nauki i obrazovanija. – 2016; 6.
  4. Kovalev A.A., Grudinskaja T.V., Kuznetsova T.P. i dr. Geterogennost' tsirkulirujuschih opuholevyh kletok // Onkologija. – 2012; 14 (2): 126–9.
  5. Osinskij S.P., Gluzman D.F. Disseminirovannye opuholevye kletki v krovi i kostnom mozge (molekuljarnyj prognoz v klinicheskoj onkologii) // Onkologija. – 2006; 2: 102–8.
  6. Kit O.I., Novikova I.A., Nikipelova E.A. i dr. Tsirkulirujuschie opuholevye kletki kak vysokospetsifichnyj prognosticheskij faktor. Obzor literatury // Mezhdunarodn. zhurn. prikladnyh i fund. issled. – 2014; 12-2: 252–7.
  7. Cohen S., Punt C., Iannotti N. et al. Relationship of Circulating Tumor Cells to Tumor Response, Progression-Free Survival, and Overall Survival in Patients With Metastatic Colorectal Cancer // J. Clin. Oncol. – 2008; 26 (19): 3213–21.
  8. Katsuno H., Zacharakis E., Aziz O. et al. Does the Presence of Circulating Tumor Cells in the Venous Drainage of Curative Colorectal Cancer Resections Determine Prognosis? A Meta-Analysis // Ann. Surg. Oncol. – 2008; 15 (11): 3083–91.
  9. Gupta G., Massague J. Cancer metastasis: building a framework // Cell. – 2006; 127 (4): 679–95.
  10. Fidler I. The pathogenesis of cancer metastasis: the 'seed and soil' hypothesis revisited // Nat. Rev. Cancer. – 2003; 3 (6): 453–8.
  11. Pantel K., Alix-Panabinres C., Riethdorf S. Cancer micrometastases // Nat. Rev. Clin. Oncol. – 2009; 6 (6): 339–51.
  12. Sleijfer S.., Gratama J., Sieuwerts A. et al. Circulating tumour cell detection on its way to routine diagnostic implementation? // Eur. J. Cancer. – 2007; 43 (18): 2645–50.
  13. Clarke M., Fuller M. Stem cells and cancer: two faces of eve // Cell. – 2006; 124 (6): 1111–5.
  14. Hanahan D., Weinberg R. The hallmarks of cancer // Cell. – 2000; 100 (1): 57–70.
  15. Smerage J., Hayes D. The measurement and therapeutic implications of circulating tumour cells in breast cancer // Br. J Cancer. – 2006; 94 (1): 8–12.
  16. Thiery J., Sleeman J.Complex networks orchestrate epithelial–mesenchymal transitions // Nat. Rev. Mol. Cell Biol. – 2006; 7: 131–42.