ENDOTHELIAL ADHESIVE FUNCTION IN NONALCOHOLIC FATTY LIVER DISEASE

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Issue: 
5
Year: 
2017

Professor P. Koroi, MD; Professor A. Yagoda, MD; S. Slyadnev Stavropol State Medical University

Examining the plasma levels of adhesion molecules of the immunoglobulin superfamily revealed increased blood adhesins in patients with nonalcoholic fatty liver disease, especially in those with severe hepatic steatosis and enhanced aminotransferase activities.

Keywords: 
nonalcoholic fatty liver disease
adhesion molecules
ICAM-1
VCAM-1
PECAM-1



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References: 
  1. Jou J., Choi S., Diehl A. Mechanisms of disease progression in nonalcoholic fatty liver disease // Semin. Liver. Dis. – 2008; 28: 370–9.
  2. Giljazova G.I., Muhoramova I.S., Rudenko Ju.A. i dr. Rol' molekul adgezii v immunnom otvete // Vestnik molodogo uchenogo. – 2012; 2: 21–7.
  3. Mosa T., Shehatta A., Khayyal A. et al. High serum levels of endothelial adhesion molecules E-selectin, ICAM-1 and VCAM in fatty liver patients // Asian. J. Biochem. – 2011; 6: 160–70.
  4. Sookoian S., Castaño G., Burgueño A. et al. Circulating levels and hepatic expression of molecular mediators of atherosclerosis in nonalcoholic fatty liver disease // Atherosclerosis. – 2010; 209 (2): 585–91.
  5. Thakur M., Sharma S., Kumar A. et al. Nonalcoholic fatty liver disease is associated with subclinical atherosclerosis independent of obesity and metabolic syndrome in Asian Indians // Atherosclerosis. – 2012; 223 (2): 507–11.
  6. Söderberg C., Marmur J., Eckes K. et al. Microvesicular fat, inter cellular adhesion molecule-1 and regulatory T-lymphocytes are of importance for the inflammatory process in livers with non-alcoholic steatohepatitis // APMIS. – 2011; 119 (7): 412–20.
  7. Weghuber D., Roden M., Franz C. et al. Vascular function in obese children with non-alcoholic fatty liver disease // Int. J. Pediatr. Obes. – 2011; 6 (2): 120–7.
  8. Webb M., Yeshua H., Zelber-Sagi S. et al. Diagnostic value of a computerized hepatorenal index for sonographic quantification of liver steatosis // Am. J. Roentgenol. – 2009; 192: 909–14.
  9. Koroj P.V., Jagoda A.V., Giljazova G.I. i dr. Mediatory mezhkletochnyh vzaimodejstvij i gistologicheskie projavlenija hronicheskoj virusnoj patologii pecheni // Ross. zhurn. gastroenterol., gepatol., koloproktol. – 2014; 5: 22–8.
  10. Jagoda A.V., Koroj P.V., Giljazova G.I. i dr. Molekuly adgezii: rol' v prognozirovanii techenija tsirroza pecheni // Arh. vnutrennej meditsiny. – 2014; 3: 28–31.
  11. Senturk O., Kocaman O., Hulagu S. et al. Endothelial dysfunction in Turkish patients with non-alcoholic fatty liver disease // Intern. Med. J. – 2008; 38 (3): 183–9.
  12. Yildirim A., Soylu Ö., Aydin A. et al. The relationship between endothelial dysfunction and serum aminotransferase levels in nonalcoholic fatty liver disease // Turk. Kardiyol. Dern. Ars. – 2007; 35 (6): 354–9.
  13. Koroj P.V., Jagoda A.V. Vlijanie protivovirusnoj terapii na funktsional'nye pokazateli endotelija pri HCV-assotsiirovannoj patologii pecheni // Med. vest. Severnogo Kavkaza. – 2009; 2: 43–8.
  14. Jagoda A.V., Kopoj P.V. Reguljatory fibpinoliza pri hronicheskoj virusnoj patologii pecheni // Ter. arh. – 2009; 81 (2): 50–3.
  15. Musso G., Gambino R., Bo S. et al. Should nonalcoholic fatty liver disease be included in the definition of metabolic syndrome? A cross-sectional comparison with Adult Treatment Panel III criteria in nonobese nondiabetic subjects // Diabetes. Care. – 2008; 31 (3): 562–8.
  16. Lomonaco R., Chen J., Cusi K. An endocrine perspective of nonalcoholic fatty liver disease (NAFLD) // Ther. Adv. Endocrinol. Metab. – 2011; 2 (5): 211–25.
  17. Tomizawa A., Hattori Y., Kasai K. et al. Adiponectin induces NFkappaB activation that leads to suppression of cytokine-induced NF-kappaB activation in vascular endothelial cells: globular adiponectin vs. high molecular weight adiponectin // Diab. Vasc. Dis. Res. – 2008; 5: 123–7.
  18. Musso G., Gambino R., De Michieli F. et al. Adiponectin gene polymorphisms modulate acute adiponectin response to dietary fat: Possible pathogenetic role in NASH // Hepatology. – 2008; 47: 1167–77.