DIAGNOSIS AND TREATMENT OF MILD AND MODERATE COGNITIVE IMPAIRMENTS

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Issue: 
4
Year: 
2017

A. Lokshina, Candidate of Medical Sciences I.M. Sechenov First Moscow State Medical University

The paper defines cognitive functions and major syndromes of their impairments and considers the neurochemistry of these conditions. Special attention is paid to the diagnosis and treatment of non-dementia (mild and moderate) cognitive impairments (CIs); the latest diagnostic criteria for these CIs are given and the basic principles of their treatment described. A variety of clinical trials show that piribedil (Pronoran) is efficient in treating non-dementia CIs.
Keywords: 
neurology
cognitive functions
non-dementia cognitive impairments
moderate cognitive impairment
mild cognitive impairment
piribedil

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References: 
  1. Diagnostic and statistical manual of mental diseases. 5 ed. (DSM-5) / London: American Psychiatric Association, 2013.
  2. Dementia. Comprehensive Principles and Practice / Oxford University Press, 2014; P. 377–83, 432–48.
  3. Zaharov V.V. Kognitivnye rasstrojstva bez dementsii: klassifikatsija, osnovnye prichiny i lechenie // Effektivnaja farmakoterapija. – 2016; 2: 22–30.
  4. Parfenov V.A., Zaharov V.V., Preobrazhenskaja I.S. Kognitivnye rasstrojstva / M., 2014; 192 s.
  5. Jahno N.N., Zaharov V.V., Lokshina A.B. i dr. Dementsii. Rukovodstvo dlja vrachej / M.: MedPress-inform, 2011; 272 s.
  6. Lokshina A.B. Legkie i umerennye kognitivnye rasstrojstva pri distsirkuljatornoj entsefalopatii. Dis. … kand. med. nauk. M., 2005; 138 s.
  7. Jahno N.N. Kognitivnye rasstrojstva v nevrologicheskoj klinike // Nevrol. zhurn. – 2006; 11 (Pril. 1): 4–12.
  8. Jahno N.N., Preobrazhenskaja I.S., Zaharov V.V. i dr. Rasprostranennost' kognitivnyh narushenij pri nevrologicheskih zabolevanijah (analiz raboty spetsializirovannogo ambulatornogo priema) // Nevrol., nejropsihiat., psihosomat. – 2012; 2: 30–5.
  9. Lokshina A.B. Sovremennye predstavlenija o nedementnyh kognitivnyh rasstrojstvah // Effektivnaja farmakoter. Nevrol. i psihiat. – 2015; 1: 36–44.
  10. Jessen F., Amariglio R., van Boxtel M. et al. A conceptual framework for research on subjective cognitive decline in preclinical Alzheimer’s disease // Alzheimer’s Dement. – 2014; 10 (6): 844–52.
  11. Caracciolo B., Gatz M., Xu W. et al. Differential distribution of subjective and objective cognitive impairment in the population: A nationwide twin-study // J. Alzheimers Dis. – 2012; 29 (2): 393–403.
  12. Bäckman L., Ginovart N., Dixon R. et al. Age-related cognitive deficits mediated by changes in the striatal dopamine system // Am. J. Psychiatry. –2000; 157: 635–7.
  13. DeKeyser J., Herregodts P., Ebinger G. The mesoneocortical dopamine neuron system // Neurology. – 1990; 40: 1660–2.
  14. Aston-Jones G., Rajkowsky J., Cohen J. Role of locus coeruleus in attention and behavioral flexibility // Biol. Psychiatry. – 1999; 46: 1309–20.
  15. Levin O.S. Umerennoe kognitivnoe rasstrojstvo: diagnostika i lechenie // Effektivnaja farmakoter. Nevrol. i psihiat. – 2012; 5: 14–20.
  16. Zaharov V.V. Rasprostranennost' i lechenie kognitivnyh narushenij v nevrologicheskoj klinike. Rezul'taty Vserossijskogo issledovanija PROMETEJ) // Consilium Medicum. – 2008; 10 (2): 114–7.
  17. Zaharov V.V. Vserossijskaja programma issledovanij epidemiologii i terapii kognitivnyh rasstrojstv v pozhilom vozraste (PROMETEJ) // Nevrol. zhurn. – 2006; 11: 27–32.
  18. Zaharov V.V., Lokshina A.B. Primenenie preparata pronoran (piribedil) pri legkih kognitivnyh rasstrojstvah u pozhilyh bol'nyh s distsirkuljatornoj entsefalopatiej // Nevrol. zhurn. – 2004; 2: 30–5.
  19. Volkov N., Logan J., Fowler J. et al Association between age-related decline in brain dopamine activity and impairment in frontal and cingulate metabolism // Am. J. Psychiatry. – 2000; 157 (1): 75–80.
  20. Nagaraia D., Jayashree S. Randomized study of the dopamine receptor agonist piribedil in the treatment of mild cognitive impairment // Am. J. Psychiatry. – 2001; 158 (9): 1517–9.
  21. Jahno N.N., Zaharov V.V., Strachunskaja E.Ja. i dr. Lechenie nedementnyh kognitivnyh narushenij u patsientov s arterial'noj gipertenziej i tserebral'nym aterosklerozom (Po dannym rossijskogo mul'titsentrovogo issledovanija FUETE) // Nevrol. zhurn. – 2012; 4: 49–55.
  22. Zaharov V.V., Milovanova O.V., Grishina D.A. i dr. Opyt primenenija pronorana v lechenii legkih i umerennyh kognitivnyh narushenij // Vrach. – 2017; 3: 32–7.