ADIPONECTIN: BIOLOGICAL AND PATHOPHYSIOLOGICAL EFFECTS

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Issue: 
8
Year: 
2016

A. Pashentseva, Candidate of Medical Sciences; Professor A. Verbovoy, MD; L. Sharonova, Candidate of Medical Sciences; Samara State Medical University

The paper discusses the current views of the biological effects of adiponectin and considers its role in the development of insulin resistance, atherosclerosis, and cardiovascular diseases.
Keywords: 
endocrinology
adiponectin
insulin resistance
type 2 diabetes mellitus
atherosclerosis
cardiovascular diseases

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References: 
  1. Dedov I.I.Problema ozhirenija: ot sindroma k zabolevaniju // Ozhirenie i metabolizm. – 2006; 1 (6): 2–4.
  2. Profilaktika saharnogo diabeta. Doklad VOZ. Per. s angl. / M.: Meditsina, 1995; 136 s. (Serija tehnicheskih dokladov VOZ; 844).
  3. Buharova G.P., Romantsova T.I. Rasprostranennost' izbytochnogo vesa i ozhirenija po dannym vyborki Moskovskogo regiona // Ozhirenie i metabo-lizm. – 2007; 2: 14–6.
  4. Després J., Lemieux I. Abdominal obesity and metabolic syndrome // Nature. – 2006; 444: 881–7.
  5. Scherer P., Williams S., Fogliano M. et al. A novel serum protein similar to C1q, produced exclusively in adipocytes // J. Biol. Chem. – 1995; 270 (45): 26746–9.
  6. Empana J. Adiponectin isoforms and cardiovascular disease: the epidemiological evidence has just begun // Eur. Heart J. – 2008; 29 (10): 1221–3.
  7. Cnop M., Havel P., Utzschneider K. et al. Relationship of adiponectin to body fatdistribution, insulin sensitivity and plasma lipoproteins: evidence for independent roles of age and sex // Diabetologia. – 2003; 46: 459–69.
  8. Matsuzawa Y., Funahashi T., Kihara S. et al. Adiponectin and Metabolic Syndrome // Arterioscler. Thromb. Vasc. Biol. – 2004; 24: 29–33.
  9. Seifi S., Nazifi S., Tabandeh M. et al. AdipoR1 and AdipoR2 gene expression are regulated by thyroid hormones in adipose tissue // Mol. Cell. Biochem. – 2013; 377 (1–2): 55–63.
  10. Kubota N., Yano W., Kubota T. et al. Adiponectin stimulates AMP-activated protein kinase in the hypothalamus and increases food intake // Cell. Metab. – 2007; 6 (1): 55–68.
  11. Ceddia R., Somwar R., Maida A. et al. Globular adiponectin increases GLUT4 translocation and glucose uptake but reduces glycogen synthesis in rat skeletal muscle cells // Diabetologia. – 2005; 48 (1): 132–9.
  12. Majorov A.Ju. Insulinorezistentnost' v patogeneze saharnogo dia beta 2 tipa // Saharnyj diabet. – 2011; 1: 35–43
  13. Lindsay R., Funahashi T., Hanson R. et al. Adiponectin and development of type 2 diabetes in the Pima Indian population // Lancet. – 2002; 360: 57–8.
  14. Li S., Shin H., Ding E. et al. Adiponectin levels and risk of type 2 diabetes: a systematic review and meta-analysis // JAMA. – 2009; 302 (2): 179–88.
  15. Tonjes A., Fasshauer M., Kratzsch J. et al. Adipokine pattern in subjects with impaired fasting glucose and impaired glucose tolerance in comparison to normal glucose tolerance and diabetes // PLoS One. – 2010; 5 (11): 13911.
  16. Wasim H., Al-Daghri N., Chetty R. et al. Relationship of serum adiponectin and resistin to glucose intolerance and fat topography in South-Asians // Cardiovasc. Diabetol. – 2006; 2 (5): 10.
  17. Verbovoj A.F., Skudaeva E.S., Pashentseva A.V. Urovni rezistina, adi ponektina i insulinorezistentnosti u patsientov s raznoj stepen'ju narushe-nij uglevodnogo obmena // Ozhirenie i metabolizm. – 2011; 3: 57–60.
  18. Kosygina A.B., Sosunov V.V., Peterkova V.A. i dr. Ekspressija gena adiponektina (ADIPOQ) v podkozhnoj i vistseral'noj zhirovoj tkani i uro-ven' adiponektina syvorotki krovi u detej // Probl. endokrinol. – 2010; 56 (6): 3–8.
  19. Verbovoj A.F., Verbovaja N.I., Kapralova I.Ju. Adiponektin, leptin i drugie metabolicheskie pokazateli u bol'nyh gipotireozom // Farmateka. – 2014; 10: 67–9.
  20. Verbovaja N.I., Kapralova I.Ju., Verbovoj A.F. Soderzhanie rezistina i drugih adipokinov u bol'nyh gipotireozom // Ter. arh. – 2014; 10: 33–5.
  21. Chubrieva S.Ju, Gluhov N.V., Zajchik A.M. Zhirovaja tkan' kak endokrin- nyj reguljator (obzor literatury) // Vestnik Sankt- Peterburgskogo univer-siteta. – 2008; 1: 32–43.
  22. Cao Y., Tao L., Yuan Y. et al. Endothelial dysfunction in adiponectin deficiency and its mechanisms involved // J. Mol. Cell. Cardiol. – 2009; 46: 413–9.
  23. Shargorodsky M., Boaz M., Goldberg Y. et al. Adiponectin and vascular properties in obese patients: is it a novel biomarker of early atherosclerosis? // Int. J. Obes. (Lond.) – 2009; 33: 553–8.
  24. Greenstein A., Khavandi K., Withers S. et al. Local inflammation and hypoxia abolish the protective anticontractile properties of perivascular fat in obese patients // Circulation. – 2009; 119: 1661–70.
  25. Shatat I., Freeman K., Vuguin P. et al. Relationship between adiponectin and ambulatory blood pressure in obese adolescents // Pediatr. Res. – 2009; 65: 691–5.
  26. Osina A.S. Otsenka vzaimosvjazi insulinorezistentnosti i endoteli al'noj disfunktsii u bol'nyh SD 2 tipa. Avtoref. dis. … kand. med. nauk. Samara, 2010; 21 s.
  27. Antoniades C., Antonopoulos A., Tousoulis D. et al. Adiponectin: from obesity to cardiovascular disease // Obes. Rev. – 2009; 10: 269–79.
  28. Wannamethee S., Whincup P., Lennon L. et al. Circulating adiponectin levels and mortality in elderly men with and without cardiovascular disease and heart failure // Arch. Intern. Med. – 2007; 167: 1510–7.
  29. Ouedraogo R., Wu X., Xu S. et al. Adiponectin suppression of high-29. glucose- induced reactive oxygen species in vascular endothelial cells: evidence for involvement of a cAMP signaling pathway // Diabetes. – 2006; 55 (6): 1840–6.
  30. Goldstein B., Scalia R., Ma X. Protective vascular and myocardial effects of adiponectin // Nat. Clin. Pract. Cardiovasc. Med. – 2009; 6 (1): 27–35.
  31. Tao L., Gao E., Jiao X. et al. Adiponectin cardioprotection after myocardial ischemia/reperfusion involves the reduction of oxidative/nitrative stress // Circulation. – 2007; 115 (11): 1408–16.
  32. Pischon T., Girman C., Hotamisligil G. et al. Plasma adiponectin levels and risk of myocardial infarction in men // JAMA. – 2004; 291 (14): 1730–7.
  33. Morkovskih N.V. Markery endokrinnoj sistemy i vospalenija kak prognosticheskie faktory riska sosudistyh oslozhnenij pri saharnom dia-bete 2 tipa. Dis. … kand. med. nauk. Samara, 2010; 142 s.
  34. Shibata R., Ouchi N., Ito M. et al. Adiponectin-mediated modulation of hypertrophic signals in the heart // Nat. Med. – 2004; 10 (12): 1384–9.
  35. Mitroshina E.V. Kliniko-laboratornye osobennosti ozhirenija, mani festirovavshego v pubertatnyj period u junoshej i muzhchin. Avtoref. dis. … kand. med. nauk. Samara, 2011; 24 s.
  36. Liao Y., Takashima S., Maeda N. et al. Exacerbation of Heart failure in adiponectin - deficient mice due to impaired regulation of AMPK and glucose metabolism // Cardiovasc. Res. – 2005; 67: 705–13.
  37. Kapralova I.Ju., Verbovoj A.F., Sharonova L.A. Soderzhanie adipoki-37. nov i pokazateli ehokardiografii u zhenschin s gipotireozom // Klinitsist. – 2014; 2: 17–21.