MARKERS OF ENDOTHELIAL DYSFUNCTION: DIAGNOSTIC AND PROGNOSTIC VALUE IN CROHN’S DISEASE

Download full text PDF
Issue: 
6
Year: 
2016

E. Stepina; Professor O. Khlynova, MD; Professor A. Tuev, MD; Professor I. Bulatova, Candidate of Medical Sciences Acad. E.A. Vagner Perm State Medical University

Patients with Crohn’s disease (CD) have been found to have endothelial dysfunction that is characterized by increases in the level of serum vascular endothelial factor (VEF) and in that of plasma desquamated endotheliocytes (DEC). The levels of VEF and DEC may act as criteria for the severity of CD and as signs of its poor course.

Keywords: 
gastroenterology
endothelial dysfunction
Crohn’s disease
vascular endothelial growth factor
desquamated endotheliocytes



It appears your Web browser is not configured to display PDF files. Download adobe Acrobat или click here to download the PDF file.

References: 
  1. Belousova E.A. Rekomendatsii po diagnostike i lecheniju bolezni Krona // Farmateka. – 2009; 13: 38–44.
  2. Halif I.L., Loranskaja I.D. Vospalitel'nye zabolevanija kishechnika (nespetsificheskij jazvennyj kolit i bolezn' Krona): klinika, diagnostika i lechenie / M.: Miklosh, 2004; s. 88.
  3. Baumgart D., Sandborn W. Crohn's disease // Lancet. – 2012; 380 (9853): 3. 1590–605.
  4. Bojko T.I., Stojkevich M.V., Kolbasina E.V. i dr. Sostojanie funktsii 4. sosudistogo endotelija u bol'nyh s hronicheskimi vospalitel'nymi zabole-vanijami kishechnika // Suchasna gastroenterologіja. – 2010; 1 (51): 5–10.
  5. Kaser A., Nieuwenhuis E., Glimcher L. et al. Innate immunity in inflammatory 5. bowel disease. Falk symposium, 2006; r. 23–4.
  6. Jacques C. Smoking, physical activity, nutrition and lifestyle: environmental 6. factors and they impact on IBD. Falk Symposium 17, 2010; r. 411–7.
  7. Satsangi J., Morecroft N.B. Genetics of inflammatory bowel disease: scientific and clinical implications // Best Pract. Res. Clin. Gastroenterol. – 2003; 17: 3–18.
  8. Siddharth S. et al. Risk of cerebrovascular accidents and ischemic heart disease in patients with inflammatory bowel disease: a systematic review and meta-analysis // Clin. Gastroenterol. Hepatol. – 2014; 12 (3): 382–93.
  9. Rumjantsev V.G., Fomin S.A., Kirkin B.V. Ishemija v patogeneze jazvennogo kolita u pozhilyh. Tezisy VI Evropejskogo kongressa gerontologov. M., 2002.
  10. Ferrante M., Pierik M., Henckaerts L. et al. The role of vascular endothelial growth factor (VEGF) in inflammatory bowel disease // Inflamm. Bowel Dis. – 2006; 12 (9): 870–8.
  11. Ivashkin V.T. i dr. Rekomendatsii po diagnostike i lecheniju vzroslyh patsientov s bolezn'ju Krona. Rekomendatsii Rossijskoj gastroenterologiche-skoj assotsiatsii, OOO «Assotsiatsija koloproktologov Rossii» i Obschestva po izucheniju vospalitel'nyh zabolevanij kishechnika pri Assotsiatsii kolo-proktologov Rossii / M., 2013; 23 s.
  12. Hladovec J. Circulating endothelial cells as a sign of vessel wall lesions // Physiol. Bohemoslov. – 1978; 27: 140–4.
  13. Rebrova O.Ju. Statisticheskij analiz meditsinskih dannyh. Primenenie prikladnyh programm Statistica / M.: MediaSfera, 2003; 312 s.