ONYCHOMYCOSIS: TREATMENT AND PREVENTION

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Issue: 
3
Year: 
2016

Professor S. Lykova, MD; Professor L. Nemchaninova, MD; A. Spitsyna, Candidate of Medical Sciences Novosibirsk State Medical University

Onychomycosis is the most common fungal infection of the nail bed, matrix, and/ or plate. No treatment or choice of ineffective tactics leads to the progression of the disease: deformation and destruction of the nail plate. There is evidence on current approaches to therapy of this nosological entity, with emphasis on the necessity of preventing the infection and its relapses.

Keywords: 
dermatology
onychomycoses
topical therapy
naftifine
prevention of mycoses



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References: 
  1. Havlickova A., Czaika V., Friedrich M. Epidemiological trends in skin 1. mycoses worldwide // Mycoses. – 2008; 51 (4): 2–15
  2. Ghannoum M., Hajjeh R., Scher R. et al. A large-scale North American study 2. of fungal isolates from nails: the frequency of onychomycosis, fungal distribution, and antifungal susceptibility patterns // J. Am. Acad. Dermatol. – 2000; 43: 641–8.
  3. Scher R. Onychomycosis is more than a cosmetic problem // Br. J. 3. Dermatol. – 1994; 130: 15.
  4. Sergeev A.Ju., Sergeev Ju.V. Gribkovye infektsii: Rukovodstvo dlja 4. vrachej / M.: Binom, 2008; 480 s.
  5. Gupta A., Jain H., Lynde C. et al. Prevalence and epidemiology of onychomycosis in patients visiting physicians’ offices: a multicenter Canadian survey of 15,000 patients // J. Am. Acad. Dermatol. – 2000; 43: 244–8.
  6. Faergemann J., Correia O., Nowicki R. et al. Genetic predisposition – understanding underlying mechanisms of onychomycosis // J. Eur. Acad. Dermatol. Venerol. – 2005; 19: 17–9.
  7. Coreno-Couti7. ño G., Arenas R., Reyes-Terán G. Clinical presentation of onychomycosis in hiv/aids: A review of 280 mexican cases // Indian J. Dermatol. – 2011; 56: 120–1.
  8. Vasudevan Biju. Cutaneous manifestations of HIV – a detailed study of 8. morphological variants, markers of advanced disease, and the changing spectrum // Med. J. Armed Forces India. – 2012; 68: 20–7.
  9. Aly R. Ecology and epidemiology of dermatophyte infections // J. Am. Acad. 9. Dermatol. – 1994; 31: 21.
  10. Olisova O.Ju., Pinson I.Ja., Akmaeva A.R. Lazernye tehnologii v leche nii onihomikozov // Rus. med. zhurn. – 2014; 8: 635–6.
  11. Batkaev A.E., Verhogljad I.V. Sovremennye podhody k terapii mikozov stop. Opyt primenenija kompleksnogo apparata «ALOM» // Ros. zhurn. kozhnyh i venericheskih boleznej. – 2008; 2: 51–3.
  12. Matushevskaja E.V., Svirschevskaja E.V. Naftifin v terapii gribkovyh zabolevanij kozhi 40 let uspeha // Vestn. dermatol. i venerol. – 2014; 2: 72–7.
  13. Sergeev A.Ju., Sergeev Ju.V., Sergeev V.Ju. Novye kontseptsii patogene za, diagnostiki i terapii onihomikozov // Immunopatol., allergol. i infektol. – 2007; 3: 9–16.
  14. Sergeev Ju.V., Mokina E.V., Chernjavskaja M.G. i dr. Problemy i perspek tivy terapii i profilaktiki mikozov stop i onihomikozov // Rus. med. zhurn. – 2004; 18: 3–9.
  15. Kungurov N.V., Kohan M.M., Scherbakova N.V. i dr. Effektivnost' tera pii gribkovyh zabolevanij kozhi i nogtej // Klin. dermatol. i venerol. – 2008; 2: 9–16.
  16. Burova S.A. Opyt lechenija onihomikozov kistej i stop mestnymi antimi kotikami // Consilium Medicum. Dermatologija. – 2015; 1: 12–5 (v pril. k pis'mu).
  17. Yazdanparast S., Barton R. Arthroconidia production in Trichophyton rubrum and a new ex vivo model of onychomycosis // J. Med. Microbiol. – 2006; 55: 1577–81.
  18. Chiacchio N., Suarez M., Madeira C. et al. An observational and descriptive 18. study of the epidemiology of and therapeutic approach to onychomycosis in dermatology offices in Brazil // Anais Brasileiros de Dermatologia. – 2013; 88 (Suppl. 1): 3–11.
  19. Ghelardi E., Celandroni F., Gueye S. et al. Potential of ergosterolsynthesis 19. inhibitors to cause resistance or cross-resistance in Trichophyton rubrum // Antimicrob. Agents Chemother. – 2014; 58 (5): 2825–9.
  20. Ghannoumet M. et al. In Vitro Antifungal Activity of Naftifine Hydrochloride 20. against Dermatophytes // Antimicrob. Agents Chemother. – 2013; 57 (9): 4369–72.
  21. Verma A., Fleischer A, Hardas B. et al. Naftifine demonstrates potent 21. fungicidal activity against the most common dermatophyte species with no evidence of resistance // J. Am. Acad. Dermatol. – 2012; 66 (4): AB119.
  22. Amichai B., Grunwald M., Davidovici B. et al. Sunlight is said to be the best 22. of disinfectants: the efficacy of sun exposure for reducing fungal contamination in used clothes // Isr. Med. Assoc. J. – 2014; 16: 431–3.
  23. Gupta A., Brintnell W. Sanitization of contaminated footwear from 23. onychomycosis patients using ozone gas: A novel adjunct therapy for treating onychomycosis and tinea pedis? // J. Cutaneous Med. Surg. – 2013; 17 (4): 243–9
  24. Ghannoum M., Isham N., Long L. Optimization of an infected shoe model 24. for the evaluation of an ultraviolet shoe sanitizer device // J. Am. Podiatr. Med. Assoc. – 2012; 102 (4): 309–13.
  25. Bogomolova T.S., Vasil'eva N.V., Chilina G.A. Effektivnost' vozdej-25. stvija ustrojstva dlja protivogribkovoj obrabotki obuvi «Timson» na neko-torye patogennye griby // Probl. med. mikol. – 2007; 2: 26–9.