COADMINISTRATION OF HETEROGENEOUS BIOPOLYMER HYDROGEL AND HYALURONIC ACID IN OSTEOARTHRITIS: THE FIRST EXPERIENCE

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1
Year: 
2016

I. Solovyeva (1); Professor N. Shesternya (2), MD; N. Perova (4), Biol.D; Professor V. Sevastyanov (3,4), Biol.D 1 -Hospital, Research Center, Russian Academy of Sciences, Chernogolovka 2 -I.M. Sechenov First Moscow State Medical University 3 -Acad. V.I. Shumakov Center of Transplantology and Artificial Organs, Moscow 4 -Institute of Biomedical Studies and Technologies, Moscow

Comparative analysis of different treatment regimens for primary knee osteoarthritis demonstrated the efficacy of the combined intraarticular administration of heterogeneous biopolymer hydrogel and a hyaluronic acid preparation, which was best in terms of all indicators. The duration of the followup was 12 months.

Keywords: 
knee osteoarthritis
hyaluronic acid
composition of heterogeneous biopolymer hydrogel
intraarticular administration



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References: 
  1. Brandt K., Doherty M., Lohmander L. Osteoarthritis / Oxford: Oxford University Press; 1998; 22 p.
  2. Karateev A.E. Obladajut li neste roidnye protivovospalitel'nye pre-paraty patogeneticheskim dejstviem? // Sovremennaja revmatologija. – 2012; 4: 13–22.
  3. Vrandt K. The mechanism of action of nonsteroidal anti–inflammatory drugs . // J. Rheum. – 1991; 18: 120–1.
  4. Doherty M. «Condor-protection» by nonsteroidal anti–inflammatory drugs // Ann. Rheum. Dis. – 1989; 48: 619–21.
  5. Ostensen M. Cartilage changes in arthritis do non–steroidal antiphlogistics have positive or negative effects? // Tiddsskr. Nor. Laegeforen. – 1991; 111: 838–40.
  6. Elimination of stabilized hyaluronan from the knee joint in healthy men // Clin. Pharmacokinet. – 2002; 41: 603–13.
  7. Smith M., Ghosh P. The synthesis of hyaluronic acid by human synovial fibroblasts is influenced by the nature of the hyaluronate in the extracellular environment // Rheumatol. Int. – 1987; 7: 113–22.
  8. Weissman B. The structure of hyalobiuronic acid and hyaluronic acid from umbilical cord // J. Am. Chem. Soc. – 1954; 76: 1753–7.
  9. Saari H. et al. Differential effects of reactive oxygen species on native synovial fluid and purified human umbilical cord hyaluronate // Inflammation. – 1993; 17: 403–15.
  10. Sevast'janov V.I., Perova N.V., Nemets E.A. i dr. Primery eksperimental'no-klinicheskogo primenenija biosovmestimyh materialov v regenerativnoj meditsine. V kn.: V.I. Sevast'janov, M.P. Kirpichnikov. Biosovmestimye materialy / M.: OOO Meditsinskoe informatsionnoe agent-stvo, 2011; 237–52 s.
  11. Sevastianov V., Lubyako A., Perova N. et al. First trial usage of the biodegradable matrix Sphero®GEL in the reconstructive surgery. Advanced Materials / M., 2007; V.1-S: 147–52 p.
  12. Sevastianov V., Vasilets V., Agapov I. Biopolymer implants for hightechnology assistance in the field of replacement and regenerative medicine // Rare metals. – 2009; 28: 84–6.Primenenie in'ektsionnyh form biopolimernyh geterogennyh gidro-13. gelej pri degenerativno-distroficheskih porazhenijah sustavov. Prakticheskoe posobie dlja vrachej / M.: OOO Izdatel'stvo Triada, 2012; 27 s.
  13. Sajkovskij R.S., Savenkova N.A., Aver'janov A.V. i dr. Effektivnost' primenenija preparata Sferogel' dlja lechenija gonartroza // Klinicheskaja praktika. – 2013; 3: 4–10.
  14. Zajtsev V.M., Lifljandskij V.G., Marinkin V.I. Prikladnaja meditsin skaja statistika // SPb: OOO «Foliant», 2003; 432 s.
  15. Osnovy epidemiologii i statisticheskogo analiza v obschestvennom . zdorov'e i upravlenii zdravoohraneniem. Kafedra obschestvennogo zdravo-ohranenija s kursom profilakticheskoj meditsiny Moskovskoj meditsinskoj akademii im. I.M.Sechenova / M.: 2003, 59 s.
  16. Stanton A. Glantz. Primer of Biostatistics. Fourth edition, McGROW-HILL 17. Health Professions Division / New York St, 1998; 459 r.
  17. Chichasova NV. Preparaty gialuronovoj kisloty v lechenii osteoartro Sinvisk (gilan G-F 20): effektivnost' i bezopasnost' // Sovremennaja revmatol. – 2013; 4: 85–91.
  18. Huskisson E., Donnelly S. Gialuronovaja kislota v lechenii osteoartroza 19. kolennogo sustava // Revmatologija. – 1999; 38: 602–7.
  19. Wobig M., Dickhut A., Maier R. et al. Viscosupplementation with hylan G-F 20. 20: a 26-week controlled trial on efficacy and safety in the osteoarthritis knee // Clin. Ther. – 1998; 20 (3): 410–23.