THERAPEUTIC AND PROPHYLACTIC BACTERIOPHAGES: THE PAST, THE PRESENT, AND THE FUTURE

Download full text PDF
Issue: 
7
Year: 
2015

O. Darbeeva, Candidate of Medical Sciences; D. Davydov, Candidate of Biological Sciences; L. Mayskaya, Candidate of Medical Sciences; R. Parfenyuk, Candidate of Biological Sciences; Z. Durmanova; Yu. Obukhov Research Center for Examination of Medical Products, Ministry of Health of Russia, Moscow

The paper reviews the history of discovery of bacteriophage preparations and their introduction into health care practice, data on their high therapeutic activity against a broad range of bacterial infections of varying genesis. It gives a concise classification of therapeutic and prophylactic bacteriophages. There is evidence that it is promising to further investigate the use of bacteriophages as an alternative to agents for traditional antimicrobial therapy and prevention of infectious diseases, including those caused by multidrug resistant microorganisms.
Keywords: 
therapeutic and prophylactic bacteriophages
multidrug resistance
nosocomial infections
antimicrobial therapy

It appears your Web browser is not configured to display PDF files. Download adobe Acrobat или click here to download the PDF file.

References: 
  1. Veiga-Crespo P., Barros-Velázquez J. et al. What can bacteriophages do for us. Communicating Current Research and Educational Topics and Trends in Applied Microbiology. Ed. A. Mendez-Vilas / Spain: Formatex, 2007; V.2: p. 885–93.
  2. Rohwer F., Edwards R. The Phage Proteomic Tree: a genome-based taxonomy for phage // J. Bacteriol. – 200; 184: 4529–35.
  3. Jakobson L. Sovremennoe sostojanie problemy bakteriofagii 1957. Sb. trudov mezhinstituts. nauchn. konf. M., 1957. Bakteriofagija, t.V, s.19–33.
  4. d’Herell F. Le bacteriophage et son rfle dans l’immunitj / Paris: Masson, 1921.
  5. D’Erell' F. Bakteriofag i fenomen vyzdorovlenija / Tiflis, 1935.
  6. Mel'nik M.I., Hastovich R.I. Bakteriofag pri dizenterii / Gos. med. izd-vo, 1935.
  7. Krestovnikova V.A., Gubin V.M. Raspredelenie i vydelenie bakteriofaga v organizme morskoj svinki pri vvedenii ego pod kozhu // Zhurn. mikrobiol., patologii infektsionnyh boleznej. – 1924; 1 (3–4): 151–6.
  8. Sutin I.A. Bakteriofagi i ih primenenie v meditsinskoj praktike / Stalingrad: Oblastnoe knigoizdatel'stvo, 1947; s. 29–32.
  9. Ponomarev A.V., Pavlov G.A., Mihel'son M.A. Bar'ernaja funktsija tsentral'noj nervnoj sistemy i bakteriofag // Arh. biol. nauk. – 1935; 38 (2): 521–9.
  10. Parfenjuk R.L., Darbeeva O.S., Majskaja L.M. i dr. Dinamika vyvedenija lechebno-profilakticheskih bakteriofagov pri peroral'nom prieme. Fundamental'nye i prikladnye problemy meditsinskoj biotehnologii. Tezisy dokladov mezhdunarodnoj konferentsii, posvjaschennoj pamjati akademika RAMN i RAMNT I.N. Blohinoj. 25–26 aprelja 2000 goda. Moskva, Nizhnij Novgorod, 2000; s. 74.
  11. Perepanova T.S., Darbeeva O.S., Majskaja L.M. i dr. Effektivnost' preparatov bakteriofagov pri lechenii vospalitel'nyh urologicheskih zabolevanij // Urologija. – 1995; 5: 14–7.
  12. Sulakvelidze A., Kutter E. Bacteriophage therapy in humans. In: Bacteriophages: biology and applications. Eds. E. Kutter, A. Sulakvelidze / Boca Raton: CRC Press, 2005; p. 381–436.
  13. Darbeeva O.S Ispol'zovanie polivalentnogo stafilokokkovogo bakteriofaga dlja profilaktiki gnojno-septicheskih zabolevanij v akusherskih statsionarah // Akt. vopr. epidemiol. i infekts. boleznej. – 1981; 8: 158–62.
  14. Solodovnikov Ju.P., Pavlova L.I., Garnova N.A. i dr. Profilakticheskoe primenenie suhogo polivalentnogo dizenterijnogo bakteriofaga s pektinom v detskih doshkol'nyh uchrezhdenijah. K obosnovaniju taktiki i shemy primenenija bakteriofaga v sovremennyh uslovijah // Mikrobiologija. – 1971; 2: 123–7.
  15. Anpilov L.I, Prokudin A.A. Profilakticheskaja effektivnost' suhogo polivalentnogo dizenterijnogo bakteriofaga v organizovannyh voennyh kollektivah // Voenno-meditsinskij zhurnal. – 1984; 5: 39–40.
  16. Trushkov A.G. Problemy perinatologii i reproduktivnosti zdorov'ja / Perm', 2002; s. 213–5.
  17. Mezzi Haled, Pardul' M.M., Olina A.A. Opyt primenenija bakteriofagov dlja lechenija hronicheskih nespetsificheskih endometritov. Materialy 1 Vseross. nauch.-prakt. konf. «Zdorov'e i obrazovanie rebenka». Perm', 2002; s. 248–50.
  18. Brashnina N.P., Samsygina G.A., Buslaeva G.N. Opyt ispol'zovanija piobakteriofaga v lechenii enterokolitov u novorozhdennyh. Aktual'nye voprosy bakteriofagii i prikladnoj immunologii. Mat. Vsesojuzn. Simpoziuma, posv. 60-letiju Tb. NIIVS. Tbilisi, 1984; s. 176–7.
  19. Samsygina G.A., Brashnina N.P., Buslaeva G.N Ispol'zovanie piobakteriofaga v profilaktike enterokolitov u novorozhdennyh detej. Aktual'nye voprosy bakteriofagii i prikladnoj immunologii. Mat. Vsesojuzn. Simpoziuma, posv. 60-letiju Tb. NIIVS. Tbilisi, 1984; s. 245–7.
  20. Kochetkova V.A., Mamontov A.S., Moskovtseva R.L. i dr. Fagoterapija posleoperatsionnyh gnojno-vospalitel'nyh oslozhnenij u onkologicheskih bol'nyh // Sovetskaja meditsina. – 1989; 6: 23–6.
  21. Akimkin V.G., Pokrovskij V.I. Nozokomial'nyj sal'monellez vzroslyh / M., 2002; 136 s