ON THE MECHANISM OF EFFICACY OF URSODEOXYCHOLIC ACID IN CHRONIC HEPATITIS C

Download full text PDF
Issue: 
5
Year: 
2015

I. Sarvilina, MD «Novomeditsina» Medical Center, Rostov-on-Don

The investigation of the molecular components of the mechanism of action of Ursofalk® during antiviral therapy for chronic hepatitis C has demonstrated its involvement of many intermolecular interactions, which makes it possible to continue a search for new target molecules to design agents for the treatment of hepatitis C.

Keywords: 
ursodeoxycholic acid
chronic hepatitis C
mechanism of action



It appears your Web browser is not configured to display PDF files. Download adobe Acrobat или click here to download the PDF file.

References: 
  1. Il'chenko L.Ju., Vinnitskaja E.V., Vasnev O.S. i dr. Problema diagnostiki i lechenija osnovnyh oslozhnenij tsirroza pecheni // Farmateka. – 2007; 2: 71–8.
  2. Maksimov V.A. Patologija gepato-biliarnoj sistemy i biliarnaja nedostatochnost' / M.: Izdatel'stvo «Adamant'», 2013; 496 s.
  3. Mehtiev S.N., Grinevich V.B., Kravchuk, R.N. Bogdanov Biliarnyj sladzh: nereshennye voprosy // Lechaschij vrach. – 2007; 6: 24–8.
  4. Minushkin O.N., Leont'ev S.I., Maslovskij L.V. i dr. Primenenie diskriminantnoj schetnoj shkaly dlja otsenki fibroobrazovanija v pecheni u bol'nyh s hronicheskimi gepatitami // Gepatologija. – 2005; 1: 16–23.
  5. Onischenko G.G. Aktual'nye voprosy epidemiologii i profilaktiki virusnyh gepatitov V i S v Rossijskoj Federatsii // Meditsina dlja vseh. – 1999; 2 (13): 2–4.
  6. Speranskij M.D., Vostrikov G.L. Rasprostranennost' zabolevanij pecheni (gepatity i tsirrozy) sredi naselenija g. Moskvy // Eksperim. i klin. gastroenterol. – 2002; 2: 98.
  7. Shahanina I.L., Raduto O.I. Virusnye gepatity v Rossii: ofitsial'naja statistika i ekonomicheskie poteri. Tsentral'nyj NII epidemiologii Minzdrava Rossii // M. Virusnye gepatity. – 2001; 6 (18): 6–9.
  8. Lirussi F., Beccarello A., Bortolato L. et al. Long-term treatment of chronic hepatitis C with ursodeoxycholic acid: influence of HCV genotypes and severity of liver disease // Liver. – 1999; 19 (5): 381–8.