BIOCHEMICAL PARAMETERS OF LIPID METABOLISM IN PATIENTS WITH UNSTABLE ANGINA AND HEMODYNAMICALLY SIGNIFICANT CORONARY STENOSIS

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Issue: 
4
Year: 
2015

T. Petelina, MD; N. Musikhina, Candidate of Medical Sciences; Professor L. Gapon, MD; A. Takkand; I. Osipova; O. Belosludtseva Branch, Research Institute of Cardiology, Siberian Branch, Russian Academy of Medical Sciences, Tyumen Cardiology Center

Seventy-five male and female patients aged 60.1±10.7 years with coronary heart disease (CHD) and unstable angina were examined. A group of patients with hemodynamically significant coronary stenosis (HSCS) was identified by selective coronary angiography. Higher levels of atherogenic lipid fractions were found in the patients with unstable angina and HSCS than in those without HSCS, with the equivalent activation of markers for a systemic inflammatory response and with endothelial dysfunction as plasma endothelin 1 hyperproduction being in the patients of both groups. There were multiple direct correlations between the levels of atherogenic lipid fractions, inflammatory markers, and the degree of coronary artery atherosclerotic stenosis.
Keywords: 
unstable angina
hemodynamically significant stenosis
lipid spectrum
markers of inflammation

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References: 
  1. Shal'nova S.A. Epidemiologija serdechno-sosudistyh zabolevanij i faktory riska v Rossii. Kardiologija. Nats. ruk-vo / M.: GEOTAR-Media, 2007; s. 37–52.
  2. Bratus' V.V., Talaeva T.V. Vospalenie kak patogeneticheskaja osnova ateroskleroza / Kiev: Natsional'nyj nauchnyj tsentr «Institut kardiologii im. N.D. Strazhesko» AMN Ukrainy, 2007.
  3. Orlova N.V., Chukaeva, I.I., Soloshenkova O.O. i dr. Izuchenie vzaimosvjazi urovnej ostrofaznyh belkov i narushenij lipidnogo obmena u bol'-nyh IBS s porazheniem koronarnyh arterij // Kardiovask. terapija i pro-filakt. – 2008; 7 (6), pril. 1; s. 271.
  4. Tepljakov A.T., Rybal'chenko E.V., Aptekar' V.D. i dr. Retsidivy stenokardii posle stentirovanija koronarnyh arterij: vlijanie dislipidemii // Bjulleten' SO RAMN. – 2006; 1 (119): 13–7.
  5. Erbel R., Ge J., Bockisch A. et al. Value of intracoronary ultrasound and Doppler in the differentiation of angiographically normal coronary arteries: a prospective study in patients with angina pectoris // Eur. Heart J. – 1996; 17: 880–9.
  6. Eckardstein A., Schulte H., Cullen P. et al. Lipoprotein (a) Further Increases the Risk of Coronary Events in Men With High Global Cardiovascular Risk // J. Am. Coll. Cardiol. – 2001; 37 (2): 434–9.
  7. Zykov K.A., Nuraliev E.Ju., Kaznacheeva E.I. i dr. Dinamika vospali tel'nogo protsessa u bol'nyh s ostrym koronarnym sindromom i stabil'noj stenokardiej // Kardiol. vestn. – 2011; 1: 23–33.
  8. Memon L., Spasojevic-Kalimanovska V. et al. Association of C-reactive 8. protein with the Presense and Extent of Angiographically Verified Coronary Artery Disease // Exp. Med. – 2006; 209: 197–206.
  9. Gusev D.E., Potievskij B.G., Rajchevin N. i dr. Markery vospalenija pri razlichnyh formah ishemicheskoj bolezni serdtsa. // Kardiologija. – 2012; 4: 4–8.
  10. Hisashi Kai, Hisao Ikeda, Hideo Yasukawa et al. Peripheral blood levels of matrix metalloproteinases-2 and -9 are elevated in patients with acute coronary syndromes // JACC. – 1998; 32 (2): 368–72
  11. Hartmann M., von Birgelen C., Mintz G. et al. Relation between lipoprotein . (a) and fibrinogen and serial intravascular ultrasound plaque progression in left main coronary arteries // J. Am. Coll. Cardiol. – 2006; 48 (3): 446–52.
  12. Shevchenko O.P. Novye laboratornye markery angiogeneza i povrezhdenija ateroskleroticheskoj bljashki // Klin. lab. diagnostika. – 2006; 6: 23–34.
  13. Shevchenko O.P., Prirodova O.F., Orlova O.V. i dr. SD 40 ligand u bol'nyh ishemicheskoj bolezn'ju serdtsa v sochetanii s saharnym diabetom 2 tipa // Kardiovask. terapija i profilak. – 2006; 5 (7): 101–11.
  14. Vogel R. Coronary risk factors, endothelial function, and atherosclerosis: a 14. review // Clin. Cardiol. – 1997; 20 (5): 426–32.