ROLE OF MICROASPIRATION OF GASTRIC CONTENTS IN THE ETIOPATHOGENESIS AND PATHOMORPHISM OF BRONCHOPULMONARY DYSPLASIA

Download full text PDF
Issue: 
2
Year: 
2015

E. Bryksina, Candidate of Medical Sciences N.N. Burdenko Voronezh State Medical Academy, Ministry of Health of the Russian Federation

A total of 373 neonatal infants on mechanical ventilation were examined. Microaspiration of gastric contents was established from the pepsin isolated from a tracheobronchial aspirate (TBA). In the children with microaspiration, the incidence and severity of bronchopulmonary dysplasia (BPD) in all degrees of gestational maturity were found to be higher and to increase in proportion to enhanced TBA pepsin activity and a shorter gestational period. In this patient category, a classic form of BPD prevailed in preterm infants, BPD was significantly more common than in the comparison group, and a follow-up study revealed a statistically significant number of cases of chronic bronchopulmonary disease developed by 3 years of life.
Keywords: 
microaspiration
tracheobronchial aspirate
bronchopulmonary dysplasia

It appears your Web browser is not configured to display PDF files. Download adobe Acrobat или click here to download the PDF file.

References: 
  1. Ovsjannikov D.Ju. Chastota bronholegochnoj displazii v strukture respiratornyh zabolevanij na razlichnyh etapah okazanija meditsinskoj pomoschi detjam i sovremennye pokazateli letal'nosti // Pediatrija. – 2009; 88 (3): 155.
  2. Davydova I.V., Jatsyk G.V., Lukina O.F. i dr. Kliniko-funktsioal'nye osobennosti techenija bronholegochnoj displazii v pervom polugodii zhizni // Ros. pediat. zhurn. – 2008; 6: 10–3.
  3. Bancalary E., Claure N., Sosenko I. Bronchopulmonary dysplasia: changes in patogenesis, epidemiology and definition // Seminars in neonatology. – 2003; 8: 63–71.
  4. Klassifikatsija klinicheskih form bronholegochnyh zabolevanij u detej / M.: Rossijskoe respiratornoe obschestvo, 2009; s. 18.
  5. Nelson S., Chen E., Syniar G. et al. Prevalence of symptoms of 5. gastroesophageal reflux during infancy. A pediatric practice-based survey // Arch. Pediatr. Adolesc. Med. – 1997; 151 (6): 569–72.
  6. Bryksina E.Ju. Kliniko-statisticheskaja vzaimosvjaz' nevrologicheskoj patologii i funktsional'nyh narushenij zheludochno-kishechnogo trakta v neonatal'nom periode // Vrach-aspirant. – 2014; 3.1 (64): 187–91
  7. Peter C., Sprodowski N., Bohnhorst B. et al. Gastroesophageal reflux and apnea of prematurity: no temporal relationship // Pediatrics. – 2002; 109 (1): 8–11.
  8. Akinola E., Rosenkrantz T., Pappagallo M. et al. Gastroesophageal reflux in infants < 32 weeks gestational age at birth: lack of relationship to chronic lung disease // Am. J. Perinatol. – 2004; 21 (2): 57–62.
  9. Ratner A.Ju. Nevrologija novorozhdennyh: ostryj period i pozdnie oslozhnenija / M.: BINOM. Laboratorija znanij, 2005; 368 s.Patent RF №2012112393/15, 02.04.2012.
  10. Pochivalov A.V., Bryksina E.Ju., 10. Bryksin V.S., Vasilenko D.Ju. Sposob prognozirovanija tjazhesti techenija bron-holegochnoj patologii na fone gastroezofageal'nogo refljuksa u detej, naho-djaschihsja na iskustvennoj ventiljatsii legkih // Patent Rossii №2480753, MPK G 01 N 33/483.