A DIAGNOSTIC AND TREATMENT ALGORITHM AND PROGNOSIS OF SURGICAL TREATMENT FOR PANCREATIC INSULIN-PRODUCING TUMORS

DOI: https://doi.org/10.29296/25877305-2018-05-02
Download full text PDF
Issue: 
5
Year: 
2018

D. Lezhinsky; Professor A. Egorov, MD; I. Vasilyev, Candidate of Medical Sciences; S. Kondrashin, MD; E. Fominykh, Candidate of Medical Sciences; Professor G. Musaev, MD; V. Parnova, Candidate of Medical Sciences; I. Ivashov; A. Mironova; N. Abdulkhakimov University Clinical Hospital One, I.M. Sechenov First Moscow State Medical University (Sechenov University)

The clinical, laboratory, and topical diagnosis of insulin-producing neuroendocrine tumors of the pancreas can be difficult, and their surgical treatment is accompanied by a relatively high rate of complications and mortality, which, along with a favorable prognosis of the disease, makes it necessary to search for alternative approaches to diagnosis and treatment.

Keywords: 
surgery
insulinoma
diagnosis
intraoperative revision
postoperative complications



It appears your Web browser is not configured to display PDF files. Download adobe Acrobat или click here to download the PDF file.

References: 
  1. Metz D., Jensen R. Gastrointestinal neuroendocrine tumors: Pancreatic endocrine tumors // Gastroenterology. – 2008; 135: 1469–92.
  2. Vanderveen K., Grant C. Insulinoma // CancerTreat. Res. – 2010; 153: 235–52.
  3. de Herder W., Niederle B., Scoazes J. et al. Well-Differentiated Pancreatic Tumor/Carcinoma: Insulinoma // ENETS Guidelines. Neuroendocrinology. – 2006; 84: 183–8.
  4. Mathur A., Gorden P., Libutti S. Insulinoma // Surg. Clin. North Am. – 2009; 89: 1105–21.
  5. Dedov I.I., Mel'nichenko G.A., Fadeev V.V. Endokrinologija. 2-e izd. / M., 2009; 432 s.
  6. Kulke M., Anthony L., Bushnell D. et al. NANETS Treatment Guidelines: welldifferentiated neuroendocrine tumors of the stomach and pancreas // Pancreas. – 2010; 39: 735–52.
  7. Guettier J., Gorden P. Insulin secretion and insulin-producing tumors // Expert Rev. Endocrinol. Metab. – 2010; 5: 217–27.
  8. Morozov Ju.A. Sravnitel'naja otsenka informativnosti razlichnyh dooperatsionnyh metodov topicheskoj diagnostiki pri insulinomah. Avtoref. dis. … kand. med. nauk. M., 1998; 24 s.
  9. Egorov A.V., Musaev G.H., Fominyh E.V. i dr. Evoljutsija algoritma topicheskoj diagnostiki gormonal'no-aktivnyh nejroendokrinnyh opuholej podzheludochnoj zhelezy // Ann. hir. gepatol. – 2016; 1: 21.
  10. Gouya N., Vignaux O., Augui J., et al. CT, Endoscopic Sonography, and a Combined Protocol for Preoperative Evaluation of Pancreatic Insulinomas // Am. J. Roentgenol. – 2003; 181: 987–92.
  11. Ardengh J., Valiati L., Geocze S. Identification of insulinomas by endoscopic ultrasonography // Rev. Assoc. Med. Bras. – 2004; 50 (2): 167–71.
  12. Zhu L., Xue H., Sun Z. et al. Prospective comparison of biphasic contrast-enhanced CT, volume perfusion CT, and 3 Tesla MRI with diffusion-weighted imaging for insulinoma detection // J. Mang. Reson. Imaging. – 2017; 46 (6): 1648–55. DOI: 10.1002/jmri.25709.
  13. Baba Y., Miyazono N., Nakajo M. et al. Localization of insulinomas: Comparison of conventional arterial stimulation with venous sampling (ASVS) and superselective ASVS // Acta Radiol. – 2000; 41: 172–7.
  14. Akerstrom G., Hellman P. Surgery on neuroendocrine tumours // Best Pract. Res. Clin. Endocrinol. Metab. – 2007; 21: 87–109.
  15. Goh B., Ooi L., Cheow P. et al. Accurate preoperative localization of insulinomas avoids the need for blind resection and reoperation: analysis of a single institution experience with 17 surgically treated tumors over 19 years // J. Gastrointest. Surg. – 2009; 13 (6): 10717.
  16. Machado M., da Cunha J., Jukemura J. et al. Insulinoma: diagnostic strategies and surgical treatment. A 22-year experience // Hepatogastroenterology. – 2001; 48 (39): 854–8.
  17. Fendrich V., Waldmann J., Bartsch D. Surgical management of pancreatic endocrine tumors // Nat. Rev. Clin. Oncol. – 2009; 6: 419–28.
  18. Espana-Gomez M., Velazquez-Fernandez D., Bezaury P. Pancreatic insulinoma: a surgical experience // World J. Surg. – 2009; 33: 1966–70.
  19. Shan-yu Qin, Xiu-ping Lu, Hai-xing Jiang. EUS-Guided Ethanol Ablation of Insulinomas Case Series and Literature Review // Medicine (Baltimore). – 2014; 93 (14): 85.
  20. Chernousov A.F., Egorov A.V., Musaev G.H. i i dr. Mikrovolnovaja abljatsija insulinom // Annaly hirurgicheskoj gepatologii. – 2016; 21 (4): 35–40.
  21. Varshney S., Johnson C. Neuroendocrine tumors of the pancreas // Indian J. Gastroenterol. – 2000; 19 (4): 181–3.
  22. Krieger A., Smirniv A., Berelavichus S. et al. Organic hyperinsulunism: radiological diagnostics and surgical treatment // Ann: Khirurgiia (Mosk). – 2016; 6: 14–29.
  23. Crippa S., Zerbi A., Boninseqna L. et al. Surgical management of insulinomas: short and long-term outcomes after enucleations and pancreatic resections // Arch. Surg. – 2012; 147 (3): 261–6. DOI: 10.1001/archsurg.2011.1843.
  24. Menegaux F., Schmitt G., Mercadier M. Pancreatic insulinomas // Am. J. Surg. – 1993; 165 (2): 243–8.
  25. Kuzin N.M., Egorov A.V. Nejroendokrinnye opuholi podzheludochnoj zhelezy. Rukovodstvo / M.: Meditsina, 2001; 208 s.
  26. Machado M., da Cunha J., Jukemura J. et al. Insulinoma: diagnostic strategies and surgical treatment. A 22-year experience // Hepatogastroenterology. – 2001; 48 (39): 854–8.
  27. Franz R., Penzhorn H. Is total gastrec- tomy still a viable option in the manage- ment of patients with the Zollinger-Ellison syndrome? // Afr. J. Surg. – 2007; 45: 58–60.
  28. Krivko A.A. Insulinoma: otdalennye rezul'taty lechenija i razrabotka sovremennogo protokola topicheskoj diagnostiki i reabilitatsii. Dis. … kand. med. nauk. M., 2015.
  29. Chung J., Choi S., Jo S. et al. Localization and surgical treatment of the pancreatic insulinomas // ANZ J. Surg. – 2006; 76 (12): 1051–5.
  30. Wei J., Liu X., Wu J. et al. Diagnosis and surgical management of insulinomas in 33 consecutive patients at a single institution // Langenbecks Arch. Surg. – 2016; 401 (7): 1019–25.
  31. Phan G., Yeo C., Hruban R. et al. Surgical experience with pancreatic and peripancreatic neuroendocrine tumors: review of 125 patients // J. Gastrointest. Surg. – 1998; 2 (5): 472–82.